Table 2 Mutations underlie P. yoelii resistance to atovaquone
Doses | Isolates | Mutations | |
|---|---|---|---|
Qo2 | Qo1 | ||
1.44 | PyASN1 | L271V+K272R | – |
|  | PyASN2 | L271V | – |
|  | PyASN3 | F267L | – |
|  | PyASN4 | F267S | – |
|  | PyASN5 | K272R | – |
|  | PyASN6 | K272R | – |
|  | PyASN7 | K272R | – |
|  | PyASN8 | K272R | – |
|  | PyASN9 | F267L | – |
|  | PyASN10 | K272R | – |
1 | PyASN11 | I258M | – |
0.3 | PyASN12 | F267I | – |
|  | PyASN13 | F267S | – |
0.03 | PyASN14 | – | T139S |
|  | PyASN15 | – | M133I |
0.01 | PyASN16 | – | M133I |