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Table 2 Interrupted time series segmented regression analysis showing the impact of major anti-malarial interventions from 1990 to 2022

From: Time series analysis of malaria cases to assess the impact of various interventions over the last three decades and forecasting malaria in India towards the 2030 elimination goals

Year of change point

Interventions*

Factors

Beta coefficient

Standard error

t

P value

1997

EMCP

Intercept

− 366,103,779

63,332,205

− 5.781

 < 0.0001

Year

184,914

31,777

5.819

 < 0.0001

Immediate effect

− 406,760

133,185

− 3.054

0.005

Sustained effect

− 274,754

32,080

− 8.565

 < 0.0001

2006

IMCP + RDT(PF) + ACT (ASP)

Intercept

67,536,474

30,212,557

2.235

0.033

Year

− 32,693

15,125

− 2.161

0.039

Immediate effect

− 70,923

194,286

− 0.365

0.718

Sustained effect

− 70,867

20,480

− 3.460

0.002

2013

ASHA + RDT(PF + PV) + ACT(ASP/AL)

Intercept

112,158,649

18,390,013

6.099

 < 0.0001

Year

− 55,050

9190

− 5.990

 < 0.0001

Immediate effect

− 77,516

232,003

− 0.334

0.741

Sustained effect

− 69,221

33,475

− 2.068

0.048

2016

NFME + RDT(PF + PV) + ACT(ASP/AL) + LLIN (scale-up)

Intercept

122,813,847

15,355,727

7.998

 < 0.0001

Year

− 60,384

7668

− 7.875

 < 0.0001

Immediate effect

− 58,668

271,886

− 0.216

0.831

Sustained effect

− 94,662

55,948

− 1.692

0.101

  1. *EMCP: enhance malaria control programme; IMCP: intensified malaria control programme; RDT: rapid diagnostic test; Pf: plasmodium falciparum; Pv: plasmodium vivax; ACT: artemisinin combination therapy; SP: sulfadoxine pyrimethamine; ASHA: accredited social health activist; AL: artemether lumefantrine; NFME: national framework of malaria elimination; LLIN: long lasting insecticidal nets