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Table 4 Pharmacotechnical properties of various ASAQ monolayer and bilayer tablet formulations

From: The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership

         

30154C01

 

Batch n°

20454

30411

30412

30436

30437

30438

30439

layer AQ

layer AS

Formulation

tablet

monolayer

bilayer

 

granulation

wet aq.

dry

Blend control

Flowability (s/100 g)

5

6

9

11

11

7

11

NA

NA

 

Hausner index (Vo/Vf)

1.25

1.19

1.21

1.23

1.10

1.20

2.24

1.09

1.41

Tablet control

Mass (mg)

589.2

622.6

636.7

623.4

622.6

613.8

624

434.5

265.5

         

700

 

Hardness (N)

61

80

63

78

68

74

71

46

 

Friability (%)

1.50

1.27

1.39

1.80

2.55

2.23

1.79

0.31

 

Residual humidity (%)

6

ND*

ND**

1.84

1.44

1.19

1.07

1.49

1.31

 

Disintegration (min)

3.0

1.8

1.6

1.5

1.4

6.1

4.1

< 1.5

  1. Key: NA: data not available
  2. *Residual humidity not determined, Karl Fischer water content 6.35%.
  3. ** Residual humidity not determined, Karl Fischer water content 6.33%.
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Malaria Journal

ISSN: 1475-2875

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