Growth rate and pyrimethamine sensitivity of PbPf S108N parasite. (A) Growth curves of PbPf S108N and PbGFP in mice. PbPf S108N data are represented as open circles and, PbGFP data represented as filled circles. The experiments were performed in three independent studies and the data represents mean ± SD values. (B) Sensitivity of pyrimethamine against PbPf S108N parasite. The data represents mean ± SD of percentage of growth inhibition. The average ED50 from three independent studies is 1.1 mg/kg.