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  1. Research article

    Analytical sensitivity of current best-in-class malaria rapid diagnostic tests

    Rapid diagnostic tests (RDTs) are today the most widely used method for malaria diagnosis and are recommended, alongside microscopy, for the confirmation of suspected cases before the administration of anti-ma...

    Alfons Jimenez, Roxanne R. Rees-Channer, Rushini Perera, Dionicia Gamboa, Peter L. Chiodini, Iveth J. González, Alfredo Mayor and Xavier C. Ding

    Malaria Journal 2017 16:128

    Published on: 24 March 2017

  2. Case report

    Diagnostic challenges and case management of the first imported case of Plasmodium knowlesi in Sri Lanka

    Sri Lanka has achieved ‘malaria-free’ status and is now in the phase of prevention of re-introduction of malaria. Imported malaria remains a challenge to resurgence of the disease. The diagnostic challenges en...

    A. Dewanee Ranaweera, Manjula N. Danansuriya, Kusumawathie Pahalagedera, W. M. Kumudunayana T. de A. W. Gunasekera, Priyani Dharmawardena, Keng Wai Mak, Pei-Sze Jeslyn Wong, Mei-Zhi Irene Li, Cheong Huat Tan, Hapuarachchige C. Hapuarachchi, Hema D. B. Herath and Deepika Fernando

    Malaria Journal 2017 16:126

    Published on: 21 March 2017

  3. Research

    Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda

    Plasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcr...

    Stephen Tukwasibwe, Patrick Tumwebaze, Melissa Conrad, Emmanuel Arinaitwe, Moses R. Kamya, Grant Dorsey, Samuel L. Nsobya, Bryan Greenhouse and Philip J. Rosenthal

    Malaria Journal 2017 16:125

    Published on: 21 March 2017

  4. Research

    False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission

    Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a dele...

    Christina T. Kozycki, Noella Umulisa, Stephen Rulisa, Emil I. Mwikarago, Jean Pierre Musabyimana, Jean Pierre Habimana, Corine Karema and Donald J. Krogstad

    Malaria Journal 2017 16:123

    Published on: 20 March 2017

  5. Research

    Age and geographic patterns of Plasmodium falciparum malaria infection in a representative sample of children living in Burkitt lymphoma-endemic areas of northern Uganda

    Falciparum malaria is an important risk factor for African Burkitt lymphoma (BL), but few studies have evaluated malaria patterns in healthy BL-age children in populations where both diseases are endemic. To o...

    Marlena Maziarz, Tobias Kinyera, Isaac Otim, Paul Kagwa, Hadijah Nabalende, Ismail D. Legason, Martin D. Ogwang, Samuel Kirimunda, Benjamin Emmanuel, Steven J. Reynolds, Patrick Kerchan, Moses M. Joloba, Andrew W. Bergen, Kishor Bhatia, Ambrose O. Talisuna, Robert J. Biggar…

    Malaria Journal 2017 16:124

    Published on: 20 March 2017

  6. Research

    Clinical and molecular surveillance of drug resistant vivax malaria in Myanmar (2009–2016)

    One of the major challenges for control and elimination of malaria is ongoing spread and emergence of drug resistance. While epidemiology and surveillance of the drug resistance in falciparum malaria is being ...

    Myat Htut Nyunt, Jin-Hee Han, Bo Wang, Khin Myo Aye, Kyin Hla Aye, Seong-Kyun Lee, Ye Htut, Myat Phone Kyaw, Kay Thwe Han and Eun-Taek Han

    Malaria Journal 2017 16:117

    Published on: 16 March 2017

  7. Research

    Confirmation of Plasmodium falciparum in vitro resistance to monodesethylamodiaquine and chloroquine in Dakar, Senegal, in 2015

    In response to increasing resistance to anti-malarial drugs, Senegal adopted artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria in 2006. However, resistance of Plasm...

    Silman Diawara, Marylin Madamet, Mame Bou Kounta, Gora Lo, Khalifa Ababacar Wade, Aminata Nakoulima, Raymond Bercion, Rémy Amalvict, Mamadou Wague Gueye, Bécaye Fall, Bakary Diatta and Bruno Pradines

    Malaria Journal 2017 16:118

    Published on: 16 March 2017

  8. Research

    Comparison of the diagnostic performance of microscopic examination with nested polymerase chain reaction for optimum malaria diagnosis in Upper Myanmar

    Accurate diagnosis of Plasmodium infection is crucial for prompt malaria treatment and surveillance. Microscopic examination has been widely applied as the gold standard for malaria diagnosis in most part of mala...

    Jung-Mi Kang, Pyo-Yun Cho, Mya Moe, Jinyoung Lee, Hojong Jun, Hyeong-Woo Lee, Seong Kyu Ahn, Tae Im Kim, Jhang Ho Pak, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim and Byoung-Kuk Na

    Malaria Journal 2017 16:119

    Published on: 16 March 2017

  9. Research

    Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976–78

    To assess the effect on malaria prevalence, village specific monthly administrations of pyrimethamine, chlorproguanil, chloroquine or placebo were given to children in four previously treatment-naïve Liberian ...

    Irina T. Jovel, Anders Björkman, Cally Roper, Andreas Mårtensson and Johan Ursing

    Malaria Journal 2017 16:113

    Published on: 13 March 2017

  10. Research

    TOLLIP gene variant is associated with Plasmodium vivax malaria in the Brazilian Amazon

    Toll-interacting protein is a negative regulator in the TLR signaling cascade, particularly by impeding the TLR2 and, TLR4 pathway. Recently, TOLLIP was shown to regulate human TLR signaling pathways. Two common

    Larissa W. Brasil, Laila R. A. Barbosa, Felipe J. de Araujo, Allyson G. da Costa, Luan D. O. da Silva, Suzana K. Pinheiro, Anne C. G. de Almeida, Andrea Kuhn, Sheila Vitor-Silva, Gisely C. de Melo, Wuelton M. Monteiro, Marcus V. G. de Lacerda and Rajendranath Ramasawmy

    Malaria Journal 2017 16:116

    Published on: 13 March 2017

  11. Research

    Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes

    Non-human primates, such as the rhesus macaques, are the preferred model for down-selecting human malaria vaccine formulations, but the rhesus model is expensive and does not allow for direct efficacy testing ...

    Timothy W. Phares, Anthony D. May, Christopher J. Genito, Nathan A. Hoyt, Farhat A. Khan, Michael D. Porter, Margot DeBot, Norman C. Waters, Philippe Saudan and Sheetij Dutta

    Malaria Journal 2017 16:115

    Published on: 13 March 2017

  12. Review

    A systematic review of the clinical presentation, treatment and relapse characteristics of human Plasmodium ovale malaria

    Despite increased efforts to control and ultimately eradicate human malaria, Plasmodium ovale malaria is for the most part outside the focus of research or public health programmes. Importantly, the understanding...

    Mirjam Groger, Hannah S. Fischer, Luzia Veletzky, Albert Lalremruata and Michael Ramharter

    Malaria Journal 2017 16:112

    Published on: 11 March 2017

  13. Research

    Resting and feeding preferences of Anopheles stephensi in an urban setting, perennial for malaria

    The Indian city of Chennai is endemic for malaria and the known local malaria vector is Anopheles stephensi. Plasmodium vivax is the predominant malaria parasite species, though Plasmodium falciparum is present a...

    Shalu Thomas, Sangamithra Ravishankaran, N. A. Johnson Amala Justin, Aswin Asokan, Manu Thomas Mathai, Neena Valecha, Jacqui Montgomery, Matthew B. Thomas and Alex Eapen

    Malaria Journal 2017 16:111

    Published on: 10 March 2017

  14. Research

    Prevalence and determinants of malaria among children in Zambézia Province, Mozambique

    Malaria is the leading cause of death among children in Mozambique. Prevalence and factors associated with malaria are not well studied among children in rural Zambézia Province. Whether prevalence of malaria ...

    James G. Carlucci, Meridith Blevins Peratikos, Charlotte B. Cherry, Melanie L. Lopez, Ann F. Green, Lazaro González-Calvo and Troy D. Moon

    Malaria Journal 2017 16:108

    Published on: 9 March 2017

  15. Research

    Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms

    Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission. However, PQ metabolites cause haemolysis in patients deficient in the enzyme glucose-6-phosphate dehydrogenase (G...

    Anna Caroline C. Aguiar, Flávio Jr. B. Figueiredo, Patrícia D. Neuenfeldt, Tony H. Katsuragawa, Bruna B. Drawanz, Wilson Cunico, Photini Sinnis, Fidel Zavala and Antoniana U. Krettli

    Malaria Journal 2017 16:110

    Published on: 9 March 2017

  16. Research

    Preliminary survey on Anopheles species distribution in Botswana shows the presence of Anopheles gambiae and Anopheles funestus complexes

    Botswana is one of the four front line malaria elimination countries in Southern Africa, with malaria control activities that include routine vector control. Past and recent studies have shown that Anopheles arab...

    Leabaneng Tawe, Pleasure Ramatlho, Kelebogile Waniwa, Charles W. Muthoga, Ntebaleng Makate, Davis S. Ntebela, Isaac K. Quaye, Marco Pombi and Giacomo Maria Paganotti

    Malaria Journal 2017 16:106

    Published on: 7 March 2017

  17. Research

    A systematic review on malaria sero-epidemiology studies in the Brazilian Amazon: insights into immunological markers for exposure and protection

    Considerable success in reducing malaria incidence and mortality has been achieved in Brazil, leading to discussions over the possibility of moving towards elimination. However, more than reporting and countin...

    Pedro M. Folegatti, André M. Siqueira, Wuelton M. Monteiro, Marcus Vinícius G. Lacerda, Chris J. Drakeley and Érika M. Braga

    Malaria Journal 2017 16:107

    Published on: 7 March 2017

  18. Research

    Rapid diagnostic tests failing to detect Plasmodium falciparum infections in Eritrea: an investigation of reported false negative RDT results

    Relatively large number of false-negative malaria rapid diagnostic test (RDT) results for microscopically confirmed Plasmodium falciparum cases were reported from five of the six administrative regions of Eritrea...

    Araia Berhane, Mulugeta Russom, Iyassu Bahta, Filmon Hagos, Michael Ghirmai and Selam Uqubay

    Malaria Journal 2017 16:105

    Published on: 6 March 2017

  19. Research

    Passive case detection of malaria in Ratanakiri Province (Cambodia) to detect villages at higher risk for malaria

    Cambodia reduced malaria incidence by more than 75% between 2000 and 2015, a target of the Millennium Development Goal 6. The Cambodian Government aims to eliminate all forms of malaria by 2025. The country’s ...

    Somony Heng, Lies Durnez, Sokny Mao, Sovannaroth Siv, Sochantha Tho, Vanna Mean, Vincent Sluydts and Marc Coosemans

    Malaria Journal 2017 16:104

    Published on: 6 March 2017

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