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  1. Content type: Research

    Over the past decade, food insecurity, connected to erratic rains and reduced agricultural outputs, has plagued Malawi. Many households are turning to fishing to seek additional sources of income and food. The...

    Authors: Sara Berthe, Steven A. Harvey, Matthew Lynch, Hannah Koenker, Vincent Jumbe, Blessings Kaunda-Khangamwa and Don P. Mathanga

    Citation: Malaria Journal 2019 18:320

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  2. Content type: Research

    Plasmodium falciparum, the deadliest causative agent of malaria, has high prevalence in Nigeria. Drug resistance causing failure of previously effective drugs has compromised anti-malarial treatment. On this basi...

    Authors: Abel O. Idowu, Wellington A. Oyibo, Sanjib Bhattacharyya, Manjeet Khubbar, Udoma E. Mendie, Violet V. Bumah, Carolyn Black, Joseph Igietseme and Anthony A. Azenabor

    Citation: Malaria Journal 2019 18:319

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  3. Content type: Research

    Intermittent preventive treatment (IPT) of malaria is recommended as policy for certain high-risk populations, but not currently for schoolchildren. A cluster-randomized trial was conducted to evaluate the eff...

    Authors: Andrea M. Rehman, Catherine Maiteki-Sebuguzi, Samuel Gonahasa, Jaffer Okiring, Simon P. Kigozi, Clare I. R. Chandler, Chris Drakeley, Grant Dorsey, Moses R. Kamya and Sarah G. Staedke

    Citation: Malaria Journal 2019 18:318

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  4. Content type: Research

    Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is a promising candidate antigen for a blood-stage malaria vaccine. However, antigenic variation and diversity of PfAMA-1 are still major problems to desi...

    Authors: Ya-Nan Wang, Min Lin, Xue-Yan Liang, Jiang-Tao Chen, Dong-De Xie, Yu-Ling Wang, Carlos Salas Ehapo, Urbano Monsuy Eyi, Hui-Ying Huang, Jing-Li Wu, Dan-Yan Xu, Zhi-Mao Chen, Yi-Long Cao and Hai-Bin Chen

    Citation: Malaria Journal 2019 18:317

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  5. Content type: Case report

    Plasmodium vivax infection is rising in sub-Saharan Africa, where Plasmodium falciparum is responsible for more than 90% of malaria cases. While P. vivax is identified as a major cause of severe and cerebral mala...

    Authors: Maowia M. Mukhtar, Omer A. Eisawi, Seth A. Amanfo, Elwaleed M. Elamin, Zeinab S. Imam, Faiza M. Osman and Manasik E. Hamed

    Citation: Malaria Journal 2019 18:316

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  6. Content type: Research

    Surveillance is a core component of an effective system to support malaria elimination. Poor surveillance data will prevent countries from monitoring progress towards elimination and targeting interventions to...

    Authors: Christopher Lourenço, Andrew J. Tatem, Peter M. Atkinson, Justin M. Cohen, Deepa Pindolia, Darlene Bhavnani and Arnaud Le Menach

    Citation: Malaria Journal 2019 18:315

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  7. Content type: Research

    Eave ribbons treated with spatial repellents effectively prevent human exposure to outdoor-biting and indoor-biting malaria mosquitoes, and could constitute a scalable and low-cost supplement to current interv...

    Authors: Emmanuel P. Mwanga, Arnold S. Mmbando, Paul C. Mrosso, Caleb Stica, Salum A. Mapua, Marceline F. Finda, Khamis Kifungo, Andrew Kafwenji, April C. Monroe, Sheila B. Ogoma, Halfan S. Ngowo and Fredros O. Okumu

    Citation: Malaria Journal 2019 18:314

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  8. Content type: Research

    Malaria continues to impose a tremendous burden in terms of global morbidity and mortality, yet even today, a large number of diagnoses are presumptive resulting in lack of or inappropriate treatment.

    Authors: Jinsu Kim, Xiangkun Elvis Cao, Julia L. Finkelstein, Washington B. Cárdenas, David Erickson and Saurabh Mehta

    Citation: Malaria Journal 2019 18:313

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  9. Content type: Research

    Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs) from the circulation. Complement activation and reduced expression of complement regulato...

    Authors: Damian A. Oyong, Jessica R. Loughland, Arya SheelaNair, Dean Andrew, Fabian D. L. Rivera, Kim A. Piera, Timothy William, Matthew J. Grigg, Bridget E. Barber, Ashraful Haque, Christian R. Engwerda, James S. McCarthy, Nicholas M. Anstey and Michelle J. Boyle

    Citation: Malaria Journal 2019 18:312

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  10. Content type: Research

    Malaria remains one of the most important causes of morbidity and death in sub-Saharan Africa. Along with early diagnosis and treatment of malaria cases and intermittent preventive treatment in pregnancy (IPTp...

    Authors: Peter Dambach, Till Baernighausen, Issouf Traoré, Saidou Ouedraogo, Ali Sié, Rainer Sauerborn, Norbert Becker and Valérie R. Louis

    Citation: Malaria Journal 2019 18:311

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  11. Content type: Research

    After years of efforts on the control of malaria, it remains as a most deadly infectious disease. A major problem for the available anti-malarial drugs is the occurrence of drug resistance in Plasmodium. Developi...

    Authors: Saeed Yousefinejad, Marjan Mahboubifar and Rayhaneh Eskandari

    Citation: Malaria Journal 2019 18:310

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  12. Content type: Research

    Intensive malaria transmission along international borders is a significant impediment to malaria elimination in the Greater Mekong Subregion (GMS) of Southeast Asia. Passive case detection (PCD) was used to s...

    Authors: Jinting Geng, Pallavi Malla, Jiaqi Zhang, Shiling Xu, Cuiying Li, Yan Zhao, Qinghui Wang, Myat Phone Kyaw, Yaming Cao, Zhaoqing Yang and Liwang Cui

    Citation: Malaria Journal 2019 18:309

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  13. Content type: Research

    Malaria is one of the important vector-borne diseases with high fatality rates in tropical countries. The pattern of emergence and spread of novel antigenic variants, leading to escape of vaccine-induced immun...

    Authors: Hargobinder Kaur, Rakesh Sehgal, Archit Kumar, Alka Sehgal, Praveen K. Bharti, Devendra Bansal, Pradyumna K. Mohapatra, Jagadish Mahanta and Ali A. Sultan

    Citation: Malaria Journal 2019 18:308

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  14. Content type: Research

    While bed nets and insecticide spraying have had significant impact on malaria burden in many endemic regions, outdoor vector feeding and insecticide resistance may ultimately limit their contribution to elimi...

    Authors: Prashanth Selvaraj, Joshua Suresh, Edward A. Wenger, Caitlin A. Bever and Jaline Gerardin

    Citation: Malaria Journal 2019 18:307

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  15. Content type: Research

    Plasmodium falciparum malaria is a threat to public health, but Plasmodium vivax malaria is most prevalent in Latin America, where the incidence rate has been increasing since 2016, particularly in Venezuela and ...

    Authors: Meyrecler Aglair de Oliveira Padilha, Janille de Oliveira Melo, Guilherme Romano, Marcos Vinicius Malveira de Lima, Wladimir J. Alonso, Maria Anice Mureb Sallum and Gabriel Zorello Laporta

    Citation: Malaria Journal 2019 18:306

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  16. Content type: Research

    Plasmodium species feature only four to eight nuclear ribosomal units on different chromosomes, which are assumed to evolve independently according to a birth-and-death model, in which new variants originate by d...

    Authors: Josef Harl, Tanja Himmel, Gediminas Valkiūnas and Herbert Weissenböck

    Citation: Malaria Journal 2019 18:305

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  17. Content type: Research

    Studies of the association between malaria in pregnancy (MiP) and malaria during infancy have provided mixed results. A systematic review was conducted to evaluate available evidence on the impact of Plasmodium f...

    Authors: Abel Kakuru, Sarah G. Staedke, Grant Dorsey, Stephen Rogerson and Daniel Chandramohan

    Citation: Malaria Journal 2019 18:304

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  18. Content type: Review

    Next-generation sequencing (NGS) technologies are increasingly being used to address a diverse range of biological and epidemiological questions. The current understanding of malaria transmission dynamics and ...

    Authors: Sofonias K. Tessema, Jaishree Raman, Craig W. Duffy, Deus S. Ishengoma, Alfred Amambua-Ngwa and Bryan Greenhouse

    Citation: Malaria Journal 2019 18:268

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  19. Content type: Opinion

    Parasite resistance against anti-malarial drugs is a major threat to the ongoing malaria control and elimination strategies. This is especially true since resistance to the currently recommended artemisinins a...

    Authors: Deus S. Ishengoma, Queen Saidi, Carol H. Sibley, Cally Roper and Michael Alifrangis

    Citation: Malaria Journal 2019 18:267

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  20. Content type: Research

    Infection during pregnancy with Plasmodium falciparum is associated with maternal anaemia and adverse birth outcomes including low birth weight (LBW). Studies using polymerase chain reaction (PCR) techniques indi...

    Authors: Holger W. Unger, Anna Rosanas-Urgell, Leanne J. Robinson, Maria Ome-Kaius, Shadrach Jally, Alexandra J. Umbers, Willie Pomat, Ivo Mueller, Eline Kattenberg and Stephen J. Rogerson

    Citation: Malaria Journal 2019 18:302

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  21. Content type: Research

    Malaria is a huge global health burden due to its mortality, morbidity and cost to economies. It is necessary to eliminate the disease in all countries where possible to achieve the World Health Organization t...

    Authors: Mia Iyer, John Skelton, Giles de Wildt and Graziela Meza

    Citation: Malaria Journal 2019 18:301

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  22. Content type: Research

    The ability to report vaccine-induced IgG responses in terms of µg/mL, as opposed arbitrary units (AU), enables a more informed interpretation of the magnitude of the immune response, and better comparison bet...

    Authors: Geneviève M. Labbé, Kazutoyo Miura, Sarah E. Silk, Wenjuan Gu, James E. Moon, Jing Jin, Ruth O. Payne, Michael P. Fay, Sheetij Dutta, Carole A. Long and Simon J. Draper

    Citation: Malaria Journal 2019 18:300

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  23. Content type: Research

    Monitoring of malaria vectors is important for designing and maintaining effective control interventions as changes in vector-feeding habits can threaten the efficacy of interventions. At present, human landin...

    Authors: Bram van de Straat, Alexandra Hiscox, Willem Takken and Thomas R. Burkot

    Citation: Malaria Journal 2019 18:299

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  24. Content type: Research

    There is growing interest in the potential to modify houses to target mosquitoes with insecticides or repellents as they search for human hosts. One version of this ‘Lethal House Lure’ approach is the In2Care® Ea...

    Authors: Antoine M. G. Barreaux, Welbeck A. Oumbouke, Innocent Zran Tia, N’guessan Brou, Alphonsine A. Koffi, Raphaël N’guessan and Matthew B. Thomas

    Citation: Malaria Journal 2019 18:298

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  25. Content type: Research

    HIV infection is associated with more frequent and severe episodes of malaria and may be the result of altered malaria-specific B cell responses. However, it is poorly understood how HIV and the associated lym...

    Authors: Eliud O. Odhiambo, Dibyadyuti Datta, Bernard Guyah, George Ayodo, Bartholomew N. Ondigo, Benard O. Abong’o, Chandy C. John and Anne E. P. Frosch

    Citation: Malaria Journal 2019 18:297

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  26. Content type: Research

    Most malaria vector control programmes rely on indoor residual spraying of insecticides and insecticide-treated bed nets. This is effective against vector species that feed indoors at night and rest inside the...

    Authors: Staci M. Dreyer, Donovan Leiva, Marla Magaña, Marie Pott, Jonathan Kay, Alvaro Cruz, Nicole L. Achee, John P. Grieco and Jefferson A. Vaughan

    Citation: Malaria Journal 2019 18:296

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  27. Content type: Research

    Competitive outcomes between co-infecting malaria parasite lines can reveal fitness disparities in blood stage growth. Blood stage fitness costs often accompany the evolution of drug resistance, with the expec...

    Authors: Abigail R. Tirrell, Katelyn M. Vendrely, Lisa A. Checkley, Sage Z. Davis, Marina McDew-White, Ian H. Cheeseman, Ashley M. Vaughan, François H. Nosten, Timothy J. C. Anderson and Michael T. Ferdig

    Citation: Malaria Journal 2019 18:295

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  28. Content type: Research

    Insecticides are still at the core of insect pest and vector control programmes. Several lines of evidence indicate that ABC transporters are involved in detoxification processes against insecticides, includin...

    Authors: Agata Negri, Marco Ferrari, Riccardo Nodari, Edoardo Coppa, Valentina Mastrantonio, Sergio Zanzani, Daniele Porretta, Claudio Bandi, Sandra Urbanelli and Sara Epis

    Citation: Malaria Journal 2019 18:294

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  29. Content type: Research

    Resistance to all available anti-malarial drugs has emerged and spread including artemisinin derivatives and their partner drugs. Several genes involved in artemisinin and partner drugs resistance, such as pfcrt,...

    Authors: Francis Tsombeng Foguim, Marie Gladys Robert, Mamadou Wagué Gueye, Mathieu Gendrot, Silman Diawara, Joel Mosnier, Rémy Amalvict, Nicolas Benoit, Raymond Bercion, Bécaye Fall, Marylin Madamet and Bruno Pradines

    Citation: Malaria Journal 2019 18:293

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  30. Content type: Research

    Malaria remains a very important public health problem in Ethiopia. Currently, only Plasmodium falciparum and Plasmodium vivax are considered in the malaria diagnostic and treatment policies. However, the existen...

    Authors: Sindew Mekasha Feleke, Bokretsion Gidey Brhane, Hassen Mamo, Ashenafi Assefa, Adugna Woyessa, Guilherme Maerschner Ogawa and Vitaliano Cama

    Citation: Malaria Journal 2019 18:292

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  31. Content type: Research

    The potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis of its...

    Authors: Martin J. Smilkstein, Sovitj Pou, Alina Krollenbrock, Lisa A. Bleyle, Rozalia A. Dodean, Lisa Frueh, David J. Hinrichs, Yuexin Li, Thomas Martinson, Myrna Y. Munar, Rolf W. Winter, Igor Bruzual, Samantha Whiteside, Aaron Nilsen, Dennis R. Koop, Jane X. Kelly…

    Citation: Malaria Journal 2019 18:291

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  32. Content type: Research

    Plasmodium elongatum (cytochrome b lineage pGRW6) is a widespread avian malaria parasite, often causing severe disease in non-adapted hosts. This parasite lineage is of global distribution however, its virulence ...

    Authors: Mikas Ilgūnas, Vaidas Palinauskas, Elena Platonova, Tatjana Iezhova and Gediminas Valkiūnas

    Citation: Malaria Journal 2019 18:290

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  33. Content type: Research

    The Duffy glycoprotein acts as the entry point for merozoites of Plasmodium vivax in the invasion of red blood cells. The host–parasite relationship has revealed new perspectives regarding the association between...

    Authors: Rechfy K. Abou-Ali, Anamika Dhyani, Alexandre L. Terço, Diana M. Toro, Katiane S. Gomes, Lucianna C. Tezza, Monique A. Negreiros, Celiane S. Batista, Márcia K. S. Souza, Edalton C. B. Sanguino and Sérgio R. L. Albuquerque

    Citation: Malaria Journal 2019 18:289

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  34. Content type: Research

    The Gambia has successfully reduced malaria transmission. The human reservoir of infection could further decrease if malaria-infected individuals could be identified by highly sensitive, field-based, diagnosti...

    Authors: Julia Mwesigwa, Hannah Slater, John Bradley, Binta Saidy, Fatima Ceesay, Charles Whittaker, Ballah Kandeh, Davis Nkwakamna, Chris Drakeley, Jean-Pierre Van Geertruyden, Teun Bousema, Jane Achan and Umberto D’Alessandro

    Citation: Malaria Journal 2019 18:288

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  35. Content type: Methodology

    The human infectious reservoir for malaria consists of individuals capable of infecting mosquitoes. Oocyst prevalence and density are typical indicators of human infectivity to mosquitoes. However, identificat...

    Authors: Alex K. Musiime, Joseph Okoth, Melissa Conrad, Daniel Ayo, Ismail Onyige, John Rek, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Moses R. Kamya, Grant Dorsey, Geert-Jan van Gemert, Sarah G. Staedke, Chris Drakeley, Teun Bousema and Chiara Andolina

    Citation: Malaria Journal 2019 18:287

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  36. Content type: Research

    Strategies for combatting residual malaria by targeting vectors outdoors are gaining importance as the limitations of primary indoor interventions are reached. Strategies to target ovipositing females or her o...

    Authors: Joel O. Odero, Ulrike Fillinger, Emily J. Rippon, Daniel K. Masiga and David Weetman

    Citation: Malaria Journal 2019 18:286

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  37. Content type: Opinion

    Mutations in the propeller domain of Plasmodium falciparum kelch 13 (Pfk13) gene are associated with artemisinin resistance in Southeast Asia. Artemisinin resistance is defined by increased ring survival rate and...

    Authors: Francis Foguim Tsombeng, Mathieu Gendrot, Marie Gladys Robert, Marylin Madamet and Bruno Pradines

    Citation: Malaria Journal 2019 18:285

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  38. Content type: Research

    The MORDOR study, a cluster randomized clinical trial, showed that single-dose azithromycin (20 mg/kg) administered biannually for 2 years to preschool children reduced mortality; a study was conducted to dete...

    Authors: Evan M. Bloch, Beatriz Munoz, Zakayo Mrango, Jerusha Weaver, Leonard E. G. Mboera, Tom M. Lietman, David J. Sullivan Jr. and Sheila K. West

    Citation: Malaria Journal 2019 18:284

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  39. Content type: Methodology

    Housing mapping and household enumeration are essential for the planning, implementation, targeting, and monitoring of malaria control interventions. In many malaria endemic countries, control efforts are hind...

    Authors: Guillermo A. García, Dianna E. B. Hergott, Wonder P. Phiri, Megan Perry, Jordan Smith, Jose Osa Osa Nfumu, Jeremías Nzamio, Godwin Fuseini, Thomas Stabler, Matilde Riloha Rivas, Immo Kleinschmidt, Christopher Schwabe and Carlos A. Guerra

    Citation: Malaria Journal 2019 18:283

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  40. Content type: Research

    Effective malaria surveillance requires detailed assessments of mosquitoes biting indoors, where interventions such as insecticide-treated nets work best, and outdoors, where other interventions may be require...

    Authors: Alex J. Limwagu, Emmanuel W. Kaindoa, Halfan S. Ngowo, Emmanuel Hape, Marceline Finda, Gustav Mkandawile, Japhet Kihonda, Khamis Kifungo, Rukiyah M. Njalambaha, Damaris Matoke-Muhia and Fredros O. Okumu

    Citation: Malaria Journal 2019 18:282

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  41. Content type: Debate

    The Global Technical Strategy 2016–2030 of the World Health Organization (WHO) has the ambitious goal of malaria being eliminated from at least 35 countries by 2030. However, in areas with once-stable malaria ...

    Authors: Thomas P. Eisele

    Citation: Malaria Journal 2019 18:281

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    The Debate to this article has been published in Malaria Journal 2019 18:279

  42. Content type: Research

    The ability of Plasmodium falciparum parasites to develop resistance to widely used anti-malarials threatens malaria control and elimination efforts. Regular drug efficacy monitoring is essential for ensuring eff...

    Authors: Jaishree Raman, Frank M. Kagoro, Aaron Mabuza, Gillian Malatje, Anthony Reid, John Frean and Karen I. Barnes

    Citation: Malaria Journal 2019 18:280

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  43. Content type: Debate

    In most malaria situations, mass drug administration (MDA) will result in a rapid reduction in the incidence and prevalence of malaria in the target population. However, due to practical reasons MDA hardly eve...

    Authors: Kamini Mendis

    Citation: Malaria Journal 2019 18:279

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    The Debate to this article has been published in Malaria Journal 2019 18:281

  44. Content type: Research

    Long-lasting insecticidal nets (LLINs) were first introduced in 2010 as a vector control intervention, to complement indoor residual spraying, to reduce malaria transmission in Zimbabwe. The objective of this ...

    Authors: Oscar Tapera

    Citation: Malaria Journal 2019 18:278

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  45. Content type: Research

    HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Dihydroartemisinin–piperaquine (DPQ) is recommended for t...

    Authors: Esperança Sevene, Clifford G. Banda, Mavuto Mukaka, Sonia Maculuve, Salésio Macuacua, Anifa Vala, Mireia Piqueras, Linda Kalilani-Phiri, Jane Mallewa, Dianne J. Terlouw, Saye H. Khoo, David G. Lalloo and Victor Mwapasa

    Citation: Malaria Journal 2019 18:277

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  46. Content type: Research

    Parasites from the genus Plasmodium, the aetiological agent of malaria in humans, can also infect non-human primates (NHP), increasing the potential risk of zoonotic transmission with its associated global public...

    Authors: Silvia Rondón, Cielo León, Andrés Link and Camila González

    Citation: Malaria Journal 2019 18:276

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  47. Content type: Research

    Drug resistance within the major malaria parasites Plasmodium vivax and Plasmodium falciparum threatens malaria control and elimination in Southeast Asia. Plasmodium vivax first-line treatment drug is chloroquine...

    Authors: Chaturong Noisang, Christiane Prosser, Wieland Meyer, Waenurama Chemoh, John Ellis, Nongyao Sawangjaroen and Rogan Lee

    Citation: Malaria Journal 2019 18:275

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  48. Content type: Research

    Insecticide-treated nets (ITNs) and long-lasting insecticidal nets (LLINs) are effective for malaria prevention and are designed to provide nearly 5 years of mosquito protection. However, many ITNs and LLINs b...

    Authors: Ellen M. Santos, Jenna E. Coalson, Elizabeth T. Jacobs, Yann C. Klimentidis, Stephen Munga, Maurice Agawo, Elizabeth Anderson, Nancy Stroupe and Kacey C. Ernst

    Citation: Malaria Journal 2019 18:274

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