Articles

A panel of recombinant proteins from human-infective Plasmodium species for serological surveillance

Malaria remains a global health problem and accurate surveillance of Plasmodium parasites that are responsible for this disease is required to guide the most effective distribution of control measures. Serologica...

Authors: Nicole Müller-Sienerth, Jarrod Shilts, Khamisah Abdul Kadir, Victor Yman, Manijeh Vafa Homann, Muhammad Asghar, Billy Ngasala, Balbir Singh, Anna Färnert and Gavin J. Wright

‘We spray and walk away’: wall modifications decrease the impact of indoor residual spray campaigns through reductions in post-spray coverage

Malaria prevalence has significantly reduced since 2000, largely due to the scale-up of vector control interventions, mainly indoor residual spraying (IRS) and long-lasting insecticide-treated nets (LLINs). Gi...

Authors: Mercy A. Opiyo and Krijn P. Paaijmans

Molecular characteristics of odorant-binding protein 1 in Anopheles maculipennis

Anopheles maculipennis complex, the historic vector of malaria, causes serious medical problems worldwide and exhibits different behaviours. Studying the odorant-binding proteins (OBPs), which influence the chemo...

Authors: Mohammad Bagher Ghavami, Sakineh Khoeini and Navid Dinparast Djadid

Use of a highly-sensitive rapid diagnostic test to screen for malaria in pregnancy in Indonesia

The sensitivity of rapid diagnostic tests (RDTs) for malaria is inadequate for detecting low-density, often asymptomatic infections, such as those that can occur when screening pregnant women for malaria. The ...

Authors: Vera T. Unwin, Rukhsana Ahmed, Rintis Noviyanti, Agatha M. Puspitasari, Retno A. S. Utami, Leily Trianty, Theda Lukito, Din Syafruddin, Jeanne R. Poespoprodjo, Maria A. Santana-Morales, Feiko O. Ter Kuile and Emily R. Adams

A survey of Anopheles species composition and insecticide resistance on the island of Bubaque, Bijagos Archipelago, Guinea-Bissau

Bubaque is the most populous island of the Bijagos archipelago, a group of malaria-endemic islands situated off the coast of Guinea-Bissau, West Africa. Malaria vector control on Bubaque relies almost exclusiv...

Authors: Thomas Ant, Erin Foley, Scott Tytheridge, Colin Johnston, Adriana Goncalves, Sainey Ceesay, Mamadou Ousmane Ndiath, Muna Affara, Julien Martinez, Elizabeth Pretorius, Chris Grundy, Amabelia Rodrigues, Paulo Djata, Umberto d’Alessandro, Robin Bailey, David Mabey…

Resistance status of Anopheles gambiae s.l. to insecticides following the 2011 mass distribution campaign of long-lasting insecticidal nets (LLINs) in the Plateau Department, south-eastern Benin

In 2011, Benin’s National Malaria Control Programme (NMCP) organized a nationwide mass distribution campaign of LLINs throughout the country. Following this intervention, it was important to assess whether the...

Authors: Arthur Sovi, Renaud Govoétchan, Razaki Ossé, Come Z. Koukpo, Albert S. Salako, Thomas Syme, Rodrigue Anagonou, Augustin Fongnikin, Udoka C. Nwangwu, Frédéric Oké-Agbo, Filémon Tokponnon, Gil Germain Padonou and Martin Codjo Akogbeto

Exploring association between MBL2 gene polymorphisms and the occurrence of clinical blackwater fever through a case–control study in Congolese children

Blackwater fever (BWF), one of the most severe and life-threatening forms of falciparum malaria, is characterized by acute massive intravascular haemolysis, often leading to acute renal failure. Thus far, the ...

Authors: Joseph M. Bodi, Célestin N. Nsibu, Roland L. Longenge, Michel N. Aloni, Pierre Z. Akilimali, Patrick K. Kayembe, Ahmeddin H. Omar, Jan Verhaegen, Pierre M. Tshibassu, Prosper T. Lukusa, Aimé Lumaka and Kenji Hirayama

The effectiveness of older insecticide-treated bed nets (ITNs) to prevent malaria infection in an area of moderate pyrethroid resistance: results from a cohort study in Malawi

A previous cohort study in Malawi showed that users of new insecticide-treated bed nets (ITNs) were significantly protected against malaria compared to non-users, despite moderate levels of pyrethroid resistan...

Authors: Monica P. Shah, Laura C. Steinhardt, Dyson Mwandama, Themba Mzilahowa, John E. Gimnig, Andy Bauleni, Jacklyn Wong, Ryan Wiegand, Don P. Mathanga and Kim A. Lindblade

RDL mutations in Guangxi Anopheles sinensis populations along the China–Vietnam border: distribution frequency and evolutionary origin of A296S resistance allele

Malaria is a deadly vector-borne disease in tropical and subtropical regions. Although indigenous malaria has been eliminated in Guangxi of China, 473 confirmed cases were reported in the Northern region of ne...

Authors: Nian Liu, Xiangyang Feng and Xinghui Qiu

Preferred resting surfaces of dominant malaria vectors inside different house types in rural south-eastern Tanzania

Malaria control in Africa relies extensively on indoor residual spraying (IRS) and insecticide-treated nets (ITNs). IRS typically targets mosquitoes resting on walls, and in few cases, roofs and ceilings, usin...

Authors: Betwel J. Msugupakulya, Emmanuel W. Kaindoa, Halfan S. Ngowo, Japhet M. Kihonda, Najat F. Kahamba, Dickson S. Msaky, Damaris Matoke-Muhia, Patrick K. Tungu and Fredros O. Okumu

Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study

Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear.

Authors: Elijah Kakande, Bryan Greenhouse, Francis Bajunirwe, Chris Drakeley, Joaniter I. Nankabirwa, Andrew Walakira, Samuel L. Nsobya, Agaba Katureebe, John Rek, Emmanuel Arinaitwe, Philip J. Rosenthal, Moses R. Kamya, Grant Dorsey and Isabel Rodriguez-Barraquer

The use of spatial and genetic tools to assess Plasmodium falciparum transmission in Lusaka, Zambia between 2011 and 2015

Zambia has set itself the ambitious target of eliminating malaria by 2021. To continue tracking transmission to zero, new interventions, tools and approaches are required.

Authors: Daniel J. Bridges, Sandra Chishimba, Mulenga Mwenda, Anna M. Winters, Erik Slawsky, Brenda Mambwe, Conceptor Mulube, Kelly M. Searle, Aves Hakalima, Roy Mwenechanya and David A. Larsen

Evaluation of long-lasting indoor residual spraying of deltamethrin 62.5 SC-PE against malaria vectors in India

Deltamethrin 62.5 polymer-enhanced suspension concentrate (SC-PE) is one of the World Health Organization-approved insecticides for indoor residual spraying and was recommended to evaluate its residual activit...

Authors: Sudhansu Sekhar Sahu, Sonia Thankachy, Smrutidhara Dash, Krishnamoorthy Nallan, Subramanian Swaminathan, Gunasekaran Kasinathan and Jambulingam Purushothaman

Unlicensed medical practitioners in tribal dominated rural areas of central India: bottleneck in malaria elimination

In India, Accredited Social Health Activists (ASHAs) deliver services for diagnosis and treatment of malaria, although unlicensed medical practitioners (UMPs) (informal health providers) are most preferred in ...

Authors: Mrigendra Pal Singh, Sunil Kumar Chand, Kalyan Brata Saha, Neetiraj Singh, Ramesh C. Dhiman and Lora L. Sabin

Testing possible causes of gametocyte reduction in temporally out-of-synch malaria infections

The intraerythrocytic development cycle (IDC) of the rodent malaria Plasmodium chabaudi is coordinated with host circadian rhythms. When this coordination is disrupted, parasites suffer a 50% reduction in both as...

Authors: Mary L. Westwood, Aidan J. O’Donnell, Petra Schneider, Gregory F. Albery, Kimberley F. Prior and Sarah E. Reece

A systematic review of factors affecting adherence to malaria chemoprophylaxis amongst travellers from non-endemic countries

The aim of this systematic review was to identify predictors of actual or intended adherence with malaria chemoprophylaxis amongst travellers from non-endemic countries visiting endemic countries.

Authors: Julian Ahluwalia, Samantha K. Brooks, John Weinman and G. James Rubin

Analysis of anti-Plasmodium IgG profiles among Fulani nomadic pastoralists in northern Senegal to assess malaria exposure

Northern Senegal is a zone of very low malaria transmission, with an annual incidence of < 5/1000 inhabitants. This area, where the Senegal National Malaria Control Programme has initiated elimination activiti...

Authors: Mame Cheikh Seck, Julie Thwing, Aida Sadikh Badiane, Eric Rogier, Fatou Ba Fall, Pape Ibrahima Ndiaye, Khadim Diongue, Moustapha Mbow, Mouhamadou Ndiaye, Mamadou Alpha Diallo, Jules François Gomis, Aminata Mbaye, Tolla Ndiaye, Aminata Gaye, Mohamad Sy, Awa Bineta Déme…

Willingness-to-pay for long-lasting insecticide-treated bed nets: a discrete choice experiment with real payment in Ghana

Expanding access to long-lasting insecticidal nets (LLINs) is difficult if one is limited to government and donor financial resources. Private commercial markets could play a larger role in the continuous dist...

Authors: Y. Natalia Alfonso, Matthew Lynch, Elorm Mensah, Danielle Piccinini and David Bishai

Update to: A stakeholder workshop about modelled maps of key malaria indicator survey indicators in Madagascar

Authors: Rosalind E. Howes, Kaleem Hawa, Voahangy Fanomezana Andriamamonjy, Thierry Franchard, Raharizo Miarimbola, Sedera Aurélien Mioramalala, Jean Florent Rafamatanantsoa, Mirana Ando Mbolatiana Rahantamalala, Solo Harimalala Rajaobary, Hariniaina David Gaël Rajaonera, Andrianiaina Parfait Rakotonindrainy, Clairaut Rakotoson Andrianjatonavalona, Dina Ny Aina Liantsoa Randriamiarinjatovo, Faratiana Michèle Randrianasolo, Rado Malalatiana Ramasy Razafindratovo, Masiarivony Ravaoarimanga…

Quantification of malaria antigens PfHRP2 and pLDH by quantitative suspension array technology in whole blood, dried blood spot and plasma

Malaria diagnostics by rapid diagnostic test (RDT) relies primarily on the qualitative detection of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and Plasmodium spp lactate dehydrogenase (pLDH). As nove...

Authors: Xavier Martiáñez-Vendrell, Alfons Jiménez, Ana Vásquez, Ana Campillo, Sandra Incardona, Raquel González, Dionicia Gamboa, Katherine Torres, Wellington Oyibo, Babacar Faye, Eusebio Macete, Clara Menéndez, Xavier C. Ding and Alfredo Mayor

Indoor use of attractive toxic sugar bait in combination with long-lasting insecticidal net against pyrethroid-resistant Anopheles gambiae: an experimental hut trial in Mbé, central Côte d’Ivoire

Indoor attractive toxic sugar bait (ATSB) has potential as a supplementary vector-control and resistance-management tool, offering an alternative mode of insecticide delivery to current core vector-control int...

Authors: Joanna E. C. Furnival-Adams, Soromane Camara, Mark Rowland, Alphonsine A. Koffi, Ludovic P. Ahoua Alou, Welbeck A. Oumbouke and Raphael N’Guessan

Identification of Plasmodium falciparum proteoforms from liver stage models

Immunization with attenuated malaria sporozoites protects humans from experimental malaria challenge by mosquito bite. Protection in humans is strongly correlated with the production of T cells targeting a het...

Authors: Benjamin Winer, Kimberly A. Edgel, Xiaoyan Zou, Julie Sellau, Sri Hadiwidjojo, Lindsey S. Garver, Christin E. McDonough, Neil L. Kelleher, Paul M. Thomas, Eileen Villasante, Alexander Ploss and Vincent R. Gerbasi

The impact of transfluthrin on the spatial repellency of the primary malaria mosquito vectors in Vietnam: Anopheles dirus and Anopheles minimus

The complexity of mosquito-borne diseases poses a major challenge to global health efforts to mitigate their impact on people residing in sub-tropical and tropical regions, to travellers and deployed military ...

Authors: Nicholas J. Martin, Vu S. Nam, Andrew A. Lover, Tran V. Phong, Tran C. Tu and Ian H. Mendenhall

In vivo/ex vivo efficacy of artemether–lumefantrine and artesunate–amodiaquine as first-line treatment for uncomplicated falciparum malaria in children: an open label randomized controlled trial in Burkina Faso

Artemisinin-based combination therapy (ACT) is recommended to improve malaria treatment efficacy and limit drug-resistant parasites selection in malaria endemic areas. 5 years after they were adopted, the effi...

Authors: Moussa Lingani, Léa Nadège Bonkian, Isidore Yerbanga, Adama Kazienga, Innocent Valéa, Hermann Sorgho, Jean Bosco Ouédraogo, Petronella Francisca Mens, Henk D. F. H. Schallig, Raffaella Ravinetto, Umberto d’Alessandro and Halidou Tinto

Utilization of insecticide-treated bed nets and care-seeking for fever and its associated socio-demographic and geographical factors among under-five children in different regions: evidence from the Myanmar Demographic and Health Survey, 2015–2016

Malaria is one of the top-five contributors to under-5 deaths in Myanmar. Use of insecticide-treated nets (ITN) and receiving early appropriate care in case of fever are the core interventions to prevent malar...

Authors: Kyi Thar Min, Thae Maung Maung, Myo Minn Oo, Tin Oo, Zaw Lin, Aung Thi and Jaya Prasad Tripathy

Genetic polymorphisms in malaria vaccine candidate Plasmodium falciparum reticulocyte-binding protein homologue-5 among populations in Lagos, Nigeria

Vaccines are the most reliable alternative to elicit sterile immunity against malaria but their development has been hindered by polymorphisms and strain-specificity in previously studied antigens. New vaccine...

Authors: Olusola Ajibaye, Akinniyi A. Osuntoki, Emmanuel O. Balogun, Yetunde A. Olukosi, Bamidele A. Iwalokun, Kolapo M. Oyebola, Kenji Hikosaka, Yoh-ichi Watanabe, Godwin U. Ebiloma, Kiyoshi Kita and Alfred Amambua-Ngwa

Childhood malaria case incidence in Malawi between 2004 and 2017: spatio-temporal modelling of climate and non-climate factors

Malaria transmission is influenced by a complex interplay of factors including climate, socio-economic, environmental factors and interventions. Malaria control efforts across Africa have shown a mixed impact....

Authors: James Chirombo, Pietro Ceccato, Rachel Lowe, Dianne J Terlouw, Madeleine C Thomson, Austin Gumbo, Peter J Diggle and Jonathan M Read

The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR

Trials to assess the efficacy of the radical cure of Plasmodium vivax malaria with 8-aminoquinolines require that most post-treatment relapses are identified, but there is no consensus on the optimal duration of ...

Authors: Koukeo Phommasone, Frank van Leth, Mallika Imwong, Gisela Henriques, Tiengkham Pongvongsa, Bipin Adhikari, Thomas J. Peto, Cholrawee Promnarate, Mehul Dorda, Pasathorn Sirithiranont, Mavuto Mukaka, Pimnara Peerawaranun, Nicholas P. J. Day, Frank Cobelens, Arjen M. Dondorp, Paul N. Newton…

Upsurge of malaria transmission after indoor residual spraying withdrawal in Atacora region in Benin, West Africa

In Benin, malaria vector control mostly relies on long-lasting, insecticidal-treated bed nets (LLINs) and indoor residual spraying (IRS) operations. From 2011 to 2016, an IRS programme has been implemented in ...

Authors: Rock Yves Aïkpon, Gil Padonou, Fortuné Dagnon, Razaki Ossè, Aurore Ogouyemi Hounto, Filémon Tokponon, Gorgias Aïkpon, Laurent Lyikirenga and Martin Akogbéto

Adherence to malaria rapid diagnostic test result among healthcare workers in Sokoto metropolis, Nigeria

Presumptive diagnosis and prescription of anti-malarial medicines to malaria rapid diagnostic test (RDT)-negative patients is a common practice among health care workers (HCWs) in Nigeria. There is paucity of ...

Authors: Aliyu Mamman Na’uzo, Dahiru Tukur, Mu’awiyyah Babale Sufiyan, Adebowale Ayo Stephen, IkeOluwapo Ajayi, Eniola Bamgboye, Abdulrazaq Abdullahi Gobir, Chukwuma David Umeokonkwo, Zainab Abdullahi and Olufemi Ajumobi

An in vitro toolbox to accelerate anti-malarial drug discovery and development

Modelling and simulation are being increasingly utilized to support the discovery and development of new anti-malarial drugs. These approaches require reliable in vitro data for physicochemical properties, per...

Authors: Susan A. Charman, Alice Andreu, Helena Barker, Scott Blundell, Anna Campbell, Michael Campbell, Gong Chen, Francis C. K. Chiu, Elly Crighton, Kasiram Katneni, Julia Morizzi, Rahul Patil, Thao Pham, Eileen Ryan, Jessica Saunders, David M. Shackleford…

The probability of a sequential Plasmodium vivax infection following asymptomatic Plasmodium falciparum and P. vivax infections in Myanmar, Vietnam, Cambodia, and Laos

Adding 8-aminoquinoline to the treatment of falciparum, in addition to vivax malaria, in locations where infections with both species are prevalent could prevent vivax reactivation. The potential risk of haemo...

Authors: Lorenz von Seidlein, Pimnara Peerawaranun, Mavuto Mukaka, Francois H. Nosten, Thuy-Nhien Nguyen, Tran Tinh Hien, Rupam Tripura, Thomas J. Peto, Tiengkham Pongvongsa, Koukeo Phommasone, Mayfong Mayxay, Mallika Imwong, James Watson, Sasithon Pukrittayakamee, Nicholas P. J. Day and Arjen M. Dondorp

Intravenous artesunate plus oral dihydroartemisinin–piperaquine or intravenous quinine plus oral quinine for optimum treatment of severe malaria: lesson learnt from a field hospital in Timika, Papua, Indonesia

Intravenous artesunate and its follow on full course dihydroartemisinin–piperaquine are the standard treatment for severe malaria in Indonesia. The current policy suggests that intravenous and oral quinine cou...

Authors: Silvester Alexandro Sikora, Jeanne Rini Poespoprodjo, Enny Kenangalem, Daniel A. Lampah, Paulus Sugiarto, Ida Safitri Laksono, Riris Andono Ahmad and E. Elsa Herdiana Murhandarwati

Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies

Artemisinin-based combination therapy (ACT) is used as the first-line treatment of uncomplicated malaria caused by the Plasmodium falciparum parasite and chloroquine-resistant Plasmodium vivax parasites. Evidence...

Authors: Guilherme Eduardo de Souza, Renata Vieira Bueno, Juliana Oliveira de Souza, Camila Lima Zanini, Fábio Cardoso Cruz, Glaucius Oliva, Rafael Victório Carvalho Guido and Anna Caroline Campos Aguiar

Genetic polymorphism of histidine rich protein 2 in Plasmodium falciparum isolates from different infection sources in Yunnan Province, China

Failed diagnoses of some falciparum malaria cases by RDTs are constantly reported in recent years. Plasmodium falciparum histidine-rich protein 2 (pfhpr2) gene deficiency has been found to be the major reason of ...

Authors: Ying Dong, Shuping Liu, Yan Deng, Yanchun Xu, Mengni Chen, Yan Liu and Jingpo Xue

Impact of vector control interventions on malaria transmission intensity, outdoor vector biting rates and Anopheles mosquito species composition in Tororo, Uganda

Long-lasting insecticidal nets (LLINs) and indoor residual spraying of insecticide (IRS) are widely recommended for the prevention of malaria in endemic regions. Data from human landing catches provide informa...

Authors: Alex K. Musiime, David L. Smith, Maxwell Kilama, John Rek, Emmanuel Arinaitwe, Joaniter I. Nankabirwa, Moses R. Kamya, Melissa D. Conrad, Grant Dorsey, Anne M. Akol, Sarah G. Staedke, Steve W. Lindsay and James P. Egonyu

Indigenously developed digital handheld Android-based Geographic Information System (GIS)-tagged tablets (TABs) in malaria elimination programme in Mangaluru city, Karnataka, India

Under-reporting, delayed diagnosis, incomplete treatment and inadequate vector management are few among many factors responsible for uninterrupted transmission of malaria in India. Information technology (IT) ...

Authors: B. Shantharam Baliga, Animesh Jain, Naren Koduvattat, B. G. Prakash Kumar, Manu Kumar, Arun Kumar and Susanta K. Ghosh

Clinical diagnostic evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria in an area receiving seasonal malaria chemoprevention in Niger

Rapid diagnostic tests (RDT) for malaria are common, but their performance varies. Tests using histidine-rich protein 2 (HRP2) antigen are most common, and many have high sensitivity. HRP2 tests can remain pos...

Authors: Matthew E. Coldiron, Bachir Assao, Céline Langendorf, Nathan Sayinzoga-Makombe, Iza Ciglenecki, Roberto de la Tour, Erwan Piriou, Mahaman Yarima Bako, Ann Mumina, Ousmane Guindo, Anne-Laure Page and Rebecca F. Grais

Economic considerations support C-reactive protein testing alongside malaria rapid diagnostic tests to guide antimicrobial therapy for patients with febrile illness in settings with low malaria endemicity

Malaria is no longer a common cause of febrile illness in many regions of the tropics. In part, this success is a result of improved access to accurate diagnosis and effective anti-malarial treatment, includin...

Authors: Yoel Lubell, Arjun Chandna, Frank Smithuis, Lisa White, Heiman F. L. Wertheim, Maël Redard-Jacot, Zachary Katz, Arjen Dondorp, Nicholas Day, Nicholas White and Sabine Dittrich

The development and evaluation of a self-marking unit to estimate malaria vector survival and dispersal distance

A clear understanding of mosquito biology is fundamental to the control efforts of mosquito-borne diseases such as malaria. Mosquito mark-release-recapture (MMRR) experiments are a popular method of measuring ...

Authors: Adam Saddler, Katharina S. Kreppel, Nakul Chitnis, Thomas A. Smith, Adrian Denz, Jason D. Moore, Mgeni M. Tambwe and Sarah J. Moore

Characterising malaria connectivity using malaria indicator survey data

Malaria connectivity describes the flow of parasites among transmission sources and sinks within a given landscape. Because of the spatial and temporal scales at which parasites are transported by their hosts,...

Authors: Carlos A. Guerra, Daniel T. Citron, Guillermo A. García and David L. Smith

Doses of chloroquine in the treatment of malaria by Plasmodium vivax in patients between 2 and 14 years of age from the Brazilian Amazon basin

A total dose of chloroquine of 25 mg/kg is recommended by the World Health Organization (WHO) to treat malaria by Plasmodium vivax. In several endemic areas, including the Brazilian Amazon basin, anti-malarial dr...

Authors: Luann Wendel Pereira de Sena, Amanda Gabryelle Nunes Cardoso Mello, Michelle Valéria Dias Ferreira, Marcieni Andrade de Ataide, Rosa Maria Dias and José Luiz Fernandes Vieira

Adherence to the referral advice after introduction of rectal artesunate for pre-referral treatment of severe malaria at the community level: a noninferiority trial in the Democratic Republic of the Congo

The Democratic Republic of the Congo adopted the strategy of using, at the community level, a dose of rectal artesunate as a pre-referral treatment for severe malaria amongst children under 5 years who could n...

Authors: Patrick M. Mvumbi, Jeanine Musau, Ousmane Faye, Hyppolite Situakibanza and Emile Okitolonda

Understanding challenges to malaria elimination in Nepal: a qualitative study with an embedded capacity-building exercise

The Nepalese Government has made significant progress toward the elimination of malaria. However, given the surge in the prevalence of non-communicable diseases, such as diabetes and hypertension, and the loca...

Authors: Shiva Raj Adhikari, Vishnu P. Sapkota, Arjun K. Thapa and Yubraj Acharya

Effectiveness of plant-based repellents against different Anopheles species: a systematic review

Plant-based repellents have been applied for generations in traditional practice as a personal protection approach against different species of Anopheles. Knowledge of traditional repellent plants is a significan...

Authors: Amin Asadollahi, Mehdi Khoobdel, Alireza Zahraei-Ramazani, Sahar Azarmi and Sayed Hussain Mosawi

Risk factor assessment for clinical malaria among forest-goers in a pre-elimination setting in Phu Yen Province, Vietnam

The transition from malaria control to elimination requires understanding and targeting interventions among high-risk populations. In Vietnam, forest-goers are often difficult to test, treat and follow-up for ...

Authors: Sara E. Canavati, Gerard C. Kelly, Cesia E. Quintero, Thuan Huu Vo, Long Khanh Tran, Colin Ohrt, Thang Duc Ngo, Duong Thanh Tran and Nicholas J. Martin

IL35 modulation altered survival, cytokine environment and histopathological consequences during malaria infection in mice

The immune modulating potential of IL-35 in multiple human disorders has been reported. Consequent upon the recognition of inflammatory cytokine activation and its preponderance for mediating pathology during ...

Authors: Ramatu Omenesa Bello, Maizaton Atmadini Abdullah, Roslaini Abd Majid, Voon Kin Chin, Mohammed Faruq Abd Rachman Isnadi, Zaid Osama Ibraheem, Mohd Khairi Hussain, Mohammed Garba Magaji and Rusliza Basir

High cases of submicroscopic Plasmodium falciparum infections in a suburban population of Lagos, Nigeria

Asymptomatic malaria parasites are significant sources of infections for onward malaria transmission. Conventional tools for malaria diagnosis such as microscopy and rapid diagnostic test kits (RDT) have relat...

Authors: Florence A. Umunnakwe, Emmanuel T. Idowu, Olusola Ajibaye, Blessed Etoketim, Samuel Akindele, Aminat O. Shokunbi, Olubunmi A. Otubanjo, Gordon A. Awandare, Alfred Amambua-Ngwa and Kolapo M. Oyebola

The 2019 Isdell:Flowers Cross Border Malaria Initiative Round Table: community engagement in the context of malaria elimination

Government officials, representatives from malaria endemic communities, and nonprofit, academic, and private sector partners convened at the 2019 Isdell:Flowers Cross Border Malaria Initiative Round Table in L...

Authors: Alexandra Gordon, Rebecca J. Vander Meulen and Alysse Maglior

Optimization of an in vivo model to study immunity to Plasmodium falciparum pre-erythrocytic stages

The circumsporozoite protein (CSP) of Plasmodium is a key surface antigen that induces antibodies and T-cells, conferring immune protection in animal models and humans. However, much of the work on CSP and immuni...

Authors: Yevel Flores-Garcia, Sonia M. Herrera, Hugo Jhun, Daniel W. Pérez-Ramos, C. Richter King, Emily Locke, Ramadevi Raghunandan and Fidel Zavala