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  1. Research

    Within-host selection of drug resistance in a mouse model of repeated interrupted treatment of Plasmodium yoelii infection

    To study within-host selection of resistant parasites, an important factor in the development of resistance to anti-malarial drugs, a mouse model of repeated interrupted malaria treatment (RIT) has been develo...

    Suci Nuralitha, Josephine E. Siregar, Din Syafruddin, Andy I. M. Hoepelman and Sangkot Marzuki

    Malaria Journal 2017 16:216

    Published on: 23 May 2017

  2. Case Study

    Intermittent preventive treatment for malaria among children in a refugee camp in Northern Uganda: lessons learned

    Northern Uganda hosts a large population of refugees from South Sudan, and malaria is one of the major health problems in the area. In 2015, intermittent preventive treatment for malaria (IPTc) was implemented...

    Matthew E. Coldiron, Estrella Lasry, Malika Bouhenia, Debashish Das, Peter Okui, Dan Nyehangane, Juliet Mwanga, Celine Langendorf, Greg Elder, Léon Salumu and Rebecca F. Grais

    Malaria Journal 2017 16:218

    Published on: 23 May 2017

  3. Research

    Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria

    Despite the widespread use and availability of rapidly acting anti-malarials, the fatality rate of severe malaria in sub-Saharan Africa remains high. Adjunctive therapies that target the host response to malar...

    Rosauro Varo, Valerie M. Crowley, Antonio Sitoe, Lola Madrid, Lena Serghides, Rubao Bila, Helio Mucavele, Alfredo Mayor, Quique Bassat and Kevin C. Kain

    Malaria Journal 2017 16:215

    Published on: 23 May 2017

  4. Research

    Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria

    The Plasmodium falciparum multidrug resistance 1 (PfMDR1), P. falciparum Ca2+-ATPase (PfATP6) and Kelch-13 propeller domain (PfK13) loci are molecular markers of parasite susceptibility to anti-malarial drugs. Th...

    Christian N. Nguetse, Ayola Akim Adegnika, Tsiri Agbenyega, Bernhards R. Ogutu, Sanjeev Krishna, Peter G. Kremsner and Thirumalaisamy P. Velavan

    Malaria Journal 2017 16:217

    Published on: 23 May 2017

  5. Research

    Glucose-6-phosphate dehydrogenase deficiency in people living in malaria endemic districts of Nepal

    Glucose-6-phosphate dehydrogenase (G6PD) is a rate limiting enzyme of the pentose phosphate pathway and is closely associated with the haemolytic disorders among patients receiving anti-malarial drugs, such as...

    Prakash Ghimire, Nihal Singh, Leonard Ortega, Komal Raj Rijal, Bipin Adhikari, Garib Das Thakur and Baburam Marasini

    Malaria Journal 2017 16:214

    Published on: 23 May 2017

  6. Research

    Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 8 in patients with P. vivax infection

    Thirty-one glycosylphosphatidylinositol (GPI)-anchored proteins of Plasmodium vivax, merozoite surface protein 1 (MSP1), MSP1 paralogue, MSP4, MSP5, MSP8, and MSP10 have been reported from homologs of Plasmodium ...

    Yang Cheng, Bo Wang, Siriruk Changrob, Jin-Hee Han, Jetsumon Sattabongkot, Kwon-Soo Ha, Patchanee Chootong, Feng Lu, Jun Cao, Myat Htut Nyunt, Won Sun Park, Seok-Ho Hong, Chae Seung Lim, Takafumi Tsuboi and Eun-Taek Han

    Malaria Journal 2017 16:211

    Published on: 22 May 2017

  7. Research

    Improving local health workers’ knowledge of malaria in the elimination phase—determinants and strategies: a cross-sectional study in rural China

    The current stage of malaria elimination in China requires experienced local health workers with sufficient knowledge of malaria who help to keep the public health system vigilant about a possible resurgence. ...

    Ruoxi Wang, Shangfeng Tang, Jun Yang, Tian Shao, Piaopiao Shao, Chunyan Liu, Da Feng, Hang Fu, Xiaoyu Chen, Tao Hu and Zhanchun Feng

    Malaria Journal 2017 16:210

    Published on: 19 May 2017

  8. Research

    Multiplex, DNase-free one-step reverse transcription PCR for Plasmodium 18S rRNA and spliced gametocyte-specific mRNAs

    Plasmodium gametocytes are sexual stages transmitted to female Anopheles mosquitoes. While Plasmodium parasites can be differentiated microscopically on Giemsa-stained blood smears, mo...

    Amelia E. Hanron, Zachary P. Billman, Annette M. Seilie, Tayla M. Olsen, Matthew Fishbaugher, Ming Chang, Thomas Rueckle, Nicole Andenmatten, Bryan Greenhouse, Emmanuel Arinaitwe, John Rek, Smita Das, Gonzalo J. Domingo, Kelly Shipman, Stefan H. Kappe, James G. Kublin…

    Malaria Journal 2017 16:208

    Published on: 19 May 2017

  9. Research

    Mass anti-malarial administration in western Cambodia: a qualitative study of factors affecting coverage

    Mass anti-malarial administration has been proposed as a key component of the Plasmodium falciparum malaria elimination strategy in the Greater Mekong sub-Region. Its effectiveness depends on high levels of cover...

    Christopher Pell, Rupam Tripura, Chea Nguon, Phaikyeong Cheah, Chan Davoeung, Chhouen Heng, Lim Dara, Ma Sareth, Arjen Dondorp, Lorenz von Seidlein and Thomas J. Peto

    Malaria Journal 2017 16:206

    Published on: 19 May 2017

  10. Research

    Testing times: trends in availability, price, and market share of malaria diagnostics in the public and private healthcare sector across eight sub-Saharan African countries from 2009 to 2015

    The World Health Organization guidelines have recommended that all cases of suspected malaria should receive a confirmatory test with microscopy or a malaria rapid diagnostic test (RDT), however evidence from ...

    Kara Hanson and Catherine Goodman

    Malaria Journal 2017 16:205

    Published on: 19 May 2017

  11. Research

    Artemisinin-based combination therapy in pregnant women in Zambia: efficacy, safety and risk of recurrent malaria

    In Zambia, malaria is one of the leading causes of morbidity and mortality, especially among under five children and pregnant women. For the latter, the World Health Organization recommends the use of artemisi...

    Michael Nambozi, Jean-Bertin Bukasa Kabuya, Sebastian Hachizovu, David Mwakazanga, Joyce Mulenga, Webster Kasongo, Jozefien Buyze, Modest Mulenga, Jean-Pierre Van Geertruyden and Umberto D’Alessandro

    Malaria Journal 2017 16:199

    Published on: 16 May 2017

  12. Research

    Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages

    Malaria is a widespread infectious disease that threatens a large proportion of the population in tropical and subtropical areas. Given the emerging resistance against the current standard anti-malaria chemoth...

    Thomas Weidner, Leonardo Lucantoni, Abed Nasereddin, Lutz Preu, Peter G. Jones, Ron Dzikowski, Vicky M. Avery and Conrad Kunick

    Malaria Journal 2017 16:192

    Published on: 15 May 2017

  13. Research

    Global survey of malaria rapid diagnostic test (RDT) sales, procurement and lot verification practices: assessing the use of the WHO–FIND Malaria RDT Evaluation Programme (2011–2014)

    Malaria rapid diagnostic tests (RDTs) play a critical role in malaria case management, and assurance of quality is a key factor to promote good adherence to test results. Since 2007, the World Health Organizat...

    Sandra Incardona, Elisa Serra-Casas, Nora Champouillon, Christian Nsanzabana, Jane Cunningham and Iveth J. González

    Malaria Journal 2017 16:196

    Published on: 15 May 2017

  14. Research

    Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia

    Artemisinin resistance is associated with delayed parasite clearance half-life in vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both phenotypes are associated with mutations i...

    Angana Mukherjee, Selina Bopp, Pamela Magistrado, Wesley Wong, Rachel Daniels, Allison Demas, Stephen Schaffner, Chanaki Amaratunga, Pharath Lim, Mehul Dhorda, Olivo Miotto, Charles Woodrow, Elizabeth A. Ashley, Arjen M. Dondorp, Nicholas J. White, Dyann Wirth…

    Malaria Journal 2017 16:195

    Published on: 12 May 2017

  15. Research

    Binding of Plasmodium falciparum to CD36 can be shielded by the glycocalyx

    Plasmodium falciparum-infected erythrocytes sequester in the microcirculation due to interaction between surface-expressed parasite proteins and endothelial receptors. Endothelial cell...

    Casper Hempel, Christian William Wang, Jørgen Anders Lindholm Kurtzhals and Trine Staalsø

    Malaria Journal 2017 16:193

    Published on: 10 May 2017

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