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  1. Cameroon is one of the countries with the highest burden of malaria. Since 2018, there has been an ongoing conflict in the country, which has reduced access to healthcare for populations in affected regions, a...

    Authors: Margaret Ebob Besem E.O, Elisabeth G. Chestnutt, Laura Donovan, Ann-Sophie Stratil, Helen Counihan, Claude Ngwayu Nkfusai, Helen Hawkings, Blanka Homolova, Kolawole Maxwell, Kevin Baker, Yakouba Zoungrana, Elvis Asangbeng Tanue, Glennise Ayuk, Noukeme Bibiche Modjenpa, Alain Metuge, Isabelle Nganmou…
    Citation: Malaria Journal 2024 23:155
  2. Plasmodium falciparum malaria is a public health issue mostly seen in tropical countries. Until now, there is no effective malaria vaccine against antigens specific to the blood-stage of P. falciparum infection. ...

    Authors: Mahugnon L. Erasme Gbaguidi, Rafiou Adamou, Sofie Edslev, Anita Hansen, Nadia D. Domingo, Celia Dechavanne, Achille Massougbodji, André Garcia, Michael Theisen, Jacqueline Milet, Eduardo A. Donadi and David Courtin
    Citation: Malaria Journal 2024 23:154
  3. The attractive targeted sugar bait (ATSB) is a novel malaria vector control tool designed to attract and kill mosquitoes using a sugar-based bait, laced with oral toxicant. Western Province, Zambia, was one of...

    Authors: Annie Arnzen, Joseph Wagman, Chama Chishya, Erica Orange, Thomas P. Eisele, Joshua Yukich, Ruth A. Ashton, Javan Chanda, Jimmy Sakala, Benjamin Chanda, Rayford Muyabe, Tresford Kaniki, Mwansa Mwenya, Gift Mwaanga, Will T. Eaton, Brooke Mancuso…
    Citation: Malaria Journal 2024 23:153
  4. Malaria is a major public health concern in Ethiopia, where more than half of the population lives in malaria risk areas. While several studies have been conducted in different eco-epidemiological settings in ...

    Authors: Kinfu Boresa, Tariku Belay, Abdissa Biruksew, Eshetu Alemayehu and Endalew Zemene
    Citation: Malaria Journal 2024 23:152
  5. Sporozoite invasion of hepatocytes is an essential step in the Plasmodium life-cycle and has similarities, at the cellular level, to merozoite invasion of erythrocytes. In the case of the Plasmodium blood-stage, ...

    Authors: Rameswara R. Segireddy, Hugo Belda, Annie S. P. Yang, Kirsten Dundas, Julia Knoeckel, Francis Galaway, Laura Wood, Doris Quinkert, Ellen Knuepfer, Moritz Treeck, Gavin J. Wright and Alexander D. Douglas
    Citation: Malaria Journal 2024 23:151
  6. Emerging artemisinin partial resistance and diagnostic resistance are a threat to malaria control in Africa. Plasmodium falciparum kelch13 (k13) propeller-domain mutations that confer artemisinin partial resistan...

    Authors: Cecile Schreidah, David Giesbrecht, Pierre Gashema, Neeva Wernsman Young, Tharcisse Munyaneza, Claude Mambo Muvunyi, Kyaw Thwai, Jean-Baptiste Mazarati, Jeffrey A. Bailey, Jonathan J. Juliano and Corine Karema
    Citation: Malaria Journal 2024 23:150
  7. Malaria elimination in Senegal requires accurate diagnosis of all Plasmodium species. Plasmodium falciparum is the most prevalent species in Senegal, although Plasmodium malariae, Plasmodium ovale, and recently P...

    Authors: Aida S. Badiane, Bassirou Ngom, Tolla Ndiaye, Deirdre Cunningham, James Campbell, Amy Gaye, Aita Sène, Mouhamad Sy, Daouda Ndiaye, Davis Nwakanma and Jean Langhorne
    Citation: Malaria Journal 2024 23:149
  8. Vector control using insecticides is a key prevention strategy against malaria. Unfortunately, insecticide resistance in mosquitoes threatens all progress in malaria control. In the perspective of managing thi...

    Authors: Behi Kouadio Fodjo, Emile Tchicaya, Laurence Aya Yao, Constant Edi, Alassane Foungoye Ouattara, Loukou Bernard Kouassi, Firmain N’dri Yokoly and Koudou Guibéhi Benjamin
    Citation: Malaria Journal 2024 23:148
  9. In Uganda, village health workers (VHWs) manage childhood illness under the integrated community case management (iCCM) strategy. Care is provided for malaria, pneumonia, and diarrhoea in a community setting. ...

    Authors: Edgar Mulogo, Moses Ntaro, Andrew Wesuta, Jane Namusisi, Peter Kawungezi, Vincent Batwala and Michael Matte
    Citation: Malaria Journal 2024 23:147
  10. In 2020, during the COVID-19 pandemic, Médecins Sans Frontières (MSF) initiated three cycles of dihydroartemisin-piperaquine (DHA-PQ) mass drug administration (MDA) for children aged three months to 15 years w...

    Authors: Eve Robinson, Adelaide Ouabo, Letitia Rose, Felipe van Braak, Jorieke Vyncke, Roberto Wright, Nell Gray, Narcisse Simon Sakama, Emmanuel Joao Aboukar, Methode Mberyo Fierte, Daniel Woinzoukou, Linn Ewers, Christian Serpande, Susanne Stein, Elburg Van Boetzelaer, Odilon Auguste Kpahina…
    Citation: Malaria Journal 2024 23:146
  11. A single 300 mg dose of tafenoquine (an 8-aminoquinoline), in combination with a standard 3-day course of chloroquine, is approved in several countries for the radical cure (prevention of relapse) of Plasmodium v...

    Authors: Raman Sharma, Hema Sharma, Siôn Jones, Isabelle Borghini-Fuhrer, Gonzalo J. Domingo, Rachel A. Gibson, Katie Rolfe, Lionel Tan, Ioana Gabriela Fiţa, Chao Chen, Panayota Bird, Anup Pingle and Stephan Duparc
    Citation: Malaria Journal 2024 23:145
  12. Monitoring therapeutic efficacy is important to ensure the efficacy of artemisinin-based combination therapy (ACT) for malaria. The current first-line treatment for uncomplicated malaria recommended by the Nat...

    Authors: Ibrahim M. Laminou, Ibrahima Issa, Eric Adehossi, Kabirou Maman, Hadiza Jackou, Eric Coulibaly, Zilahatou B. Tohon, Jehan Ahmed, Elisha Sanoussi and Daniel Koko
    Citation: Malaria Journal 2024 23:144
  13. Despite continuous prevention and control strategies in place, malaria remains a major public health problem in sub-Saharan Africa including Ethiopia. Moreover, prevalence of malaria differs in different geogr...

    Authors: Girma Yutura, Fekadu Massebo, Nigatu Eligo, Abena Kochora and Teklu Wegayehu
    Citation: Malaria Journal 2024 23:143
  14. The newly developed malaria vaccine called “R21/Matrix-M malaria vaccine” showed a high safety and efficacy level, and Ghana is the first country to approve this new vaccine. The present study aimed to evaluat...

    Authors: Mohamed Fakhry Hussein, Frank Kyei-Arthur, Marina Saleeb, Sylvester Kyei-Gyamfi, Theophilus Abutima, Ignatius Great Sakada and Ramy Mohamed Ghazy
    Citation: Malaria Journal 2024 23:142
  15. The development of resistance by Plasmodium falciparum is a burdening hazard that continues to undermine the strides made to alleviate malaria. As such, there is an increasing need to find new alternative strateg...

    Authors: Muzi N. Buthelezi, Vhahangwele G. Tshililo, Abidemi P. Kappo and Mthokozisi B. C. Simelane
    Citation: Malaria Journal 2024 23:141
  16. Plasmodium vivax relapses due to dormant liver hypnozoites can be prevented with primaquine. However, the dose must be adjusted in individuals with glucose-6-phosphate-dehydrogenase (G6PD) deficiency. In French G...

    Authors: Laureen Dahuron, Juste Goungounga, Moustapha Drame, Maylis Douine, Mathieu Nacher, Théo Blaise, Emilie Mosnier, Lise Musset, Marie Fouillet, Félix Djossou and Loïc Epelboin
    Citation: Malaria Journal 2024 23:140
  17. In 2021 and 2023, the World Health Organization approved RTS,S/AS01 and R21/Matrix M malaria vaccines, respectively, for routine immunization of children in African countries with moderate to high transmission...

    Authors: Beatus M. Lyimo, Catherine Bakari, Zachary R. Popkin-Hall, David J. Giesbrecht, Misago D. Seth, Dativa Pereus, Zulfa I. Shabani, Ramadhan Moshi, Ruth Boniface, Celine I. Mandara, Rashid Madebe, Jonathan J. Juliano, Jeffrey A. Bailey and Deus S. Ishengoma
    Citation: Malaria Journal 2024 23:139
  18. Artemisinin resistance in Plasmodium falciparum threatens global malaria elimination efforts. To contain and then eliminate artemisinin resistance in Eastern Myanmar a network of community-based malaria posts was...

    Authors: Aung Myint Thu, Aung Pyae Phyo, Chanapat Pateekhum, Jade D. Rae, Jordi Landier, Daniel M. Parker, Gilles Delmas, Wanitda Watthanaworawit, Alistair R. D. McLean, Ann Arya, Ann Reyes, Xue Li, Olivo Miotto, Kyaw Soe, Elizabeth A. Ashley, Arjen Dondorp…
    Citation: Malaria Journal 2024 23:138
  19. Universal coverage with insecticide-treated nets (ITNs) is important for malaria control and elimination. The emergence and intensification of insecticide resistance threatens progress made through the deploym...

    Authors: Jenny Shannon, Moubassira Kagone, Baltazar Candrinho, Sylvanus Otikwu, Chantal Ingabire, Adama Gansane, Samy Pooda, Fofana Aboubacar, Fatou Ouattara, Binete Savaio, Celestino Joanguete, Lucio Sixpence, Hannah Koenker, Perpetua Uhomoibhi, Okefu Oyale Okoko, Onoja Ali…
    Citation: Malaria Journal 2024 23:137
  20. The direct membrane feeding assay (DMFA), whereby gametocyte-infected blood is collected from human donors and from which mosquitoes feed through a membrane, is proving essential for assessing parameters influ...

    Authors: Seydou Bienvenu Ouattara, Domonbabele F. D. S. Hien, Ekôbié T. Nao, Prisca S. L. Paré, Edwige Guissou, Anna Cohuet, Isabelle Morlais, Rakiswendé S. Yerbanga, Kounbobr R. Dabiré, Jean Bosco Ouédraogo, Karine Mouline and Thierry Lefèvre
    Citation: Malaria Journal 2024 23:135
  21. Studies on haemosporidian diversity, including origin of human malaria parasites, malaria's zoonotic dynamic, and regional biodiversity patterns, have used target gene approaches. However, current methods have...

    Authors: M. Andreína Pacheco, Axl S. Cepeda, Erica A. Miller, Scott Beckerman, Mitchell Oswald, Evan London, Nohra E. Mateus-Pinilla and Ananias A. Escalante
    Citation: Malaria Journal 2024 23:134
  22. Drug repurposing offers a strategic alternative to the development of novel compounds, leveraging the known safety and pharmacokinetic profiles of medications, such as linezolid and levofloxacin for tuberculos...

    Authors: Thomas Hanscheid, Claire Ruiz del Portal Luyten, Sabine M. Hermans and Martin P. Grobusch
    Citation: Malaria Journal 2024 23:132
  23. In Nigeria, seasonal malaria chemoprevention (SMC) is typically administered door-to-door to children under five by community medicine distributors during high transmission seasons. While door-to-door distribu...

    Authors: Sikai Huang, Kevin Baker, Taiwo Ibinaiye, Olusola Oresanya, Chuks Nnaji and Sol Richardson
    Citation: Malaria Journal 2024 23:131
  24. The sequestration of Plasmodium falciparum infected erythrocytes in the placenta, and the resulting inflammatory response affects maternal and child health. Despite existing information, little is known about the...

    Authors: Carolina López-Guzmán, Ana María García, Juan Diego Ramirez, Trinidad Torres Aliaga, Alejandro Fernández-Moya, Ulrike Kemmerling and Ana María Vásquez
    Citation: Malaria Journal 2024 23:130
  25. Malaria has remained a persistent global health problem. Despite multiple government and donor initiatives to eradicate malaria and its detrimental effects on Uganda's health outcomes, the incidence of malaria...

    Authors: Jemimah Katushabe, John Bosco Nnyanzi and Gertrude Sebunya Muwanga
    Citation: Malaria Journal 2024 23:129
  26. Malaria treatment in sub-Saharan Africa is faced with challenges including unreliable supply of efficacious agents, substandard medicines coupled with high price of artemisinin-based combinations. This affects...

    Authors: Moses Ocan, Loyce Nakalembe, Caroline Otike, Tayebwa Mordecai, Joan Birungi and Sam Nsobya
    Citation: Malaria Journal 2024 23:128
  27. The decreasing residual efficacy of insecticides is an important factor when making decisions on insecticide choice for national malaria control programmes. The major challenge to using chemicals for vector co...

    Authors: Rajendra Maharaj, Ishen Seocharan, Vishan Lakan, Zuziwe Nyawo, Moses Mkhabela and Yusentha Balakrishna
    Citation: Malaria Journal 2024 23:127
  28. Introduction: Malaria continues to be the leading cause of hospitalization and death in Angola, a country in sub- Saharan Africa. In 2023, in the first quarter, 2,744,682 cases were registered, and of these 2,...

    Authors: Euclides N. M. Sacomboio, Santo D. Zua, Adelino T. Tchivango, António D. Pululu, Adilson C. D. Caumba, Adelina B. M. Paciência, Danilson V. Sati, Sabina G. Agostinho, Yolanda S. Agostinho, Fernando G. Mazanga, Neusa B. Ntambo, Cruz S. Sebastião, Joana P. Paixão and Joana Morais
    Citation: Malaria Journal 2024 23:126
  29. Despite efforts made to reduce morbidity and mortality associated with malaria, especially in sub-Saharan Africa, malaria continues to be a public health concern that requires innovative efforts to reach the W...

    Authors: Nicholas Ekow Thomford, Tracy Kellermann, Robert Peter Biney, Charné Dixon, Samuel Badu Nyarko, Richmond Owusu Ateko, Martins Ekor and George B. Kyei
    Citation: Malaria Journal 2024 23:125
  30. Malaria contributes to excess child mortality in The Gambia. Children under five are at risk of severe malaria and death if not treated promptly and appropriately. It is crucial that a child with fever receive...

    Authors: Laura Arntson, Katherine R. McLaughlin and Ellen Smit
    Citation: Malaria Journal 2024 23:124
  31. Malaria is still a disease of global public health importance and children under-five years of age are the most vulnerable to the disease. Nigeria adopted the “test and treat” strategy in the national malaria ...

    Authors: Mina Whyte, Latifat Ibisomi, Tobias Chirwa, Jonathan Levin and Wiedaad Slemming
    Citation: Malaria Journal 2024 23:123
  32. Anopheles coluzzii is a primary vector of malaria found in West and Central Africa, but its presence has hitherto never been documented in Kenya. A thorough understanding of vector bionomics is important as it en...

    Authors: Luna Kamau, Kelly L. Bennett, Eric Ochomo, Jeremy Herren, Silas Agumba, Samson Otieno, Diana Omoke, Damaris Matoke-Muhia, David Mburu, Joseph Mwangangi, Edith Ramaita, Elijah O. Juma, Charles Mbogo, Sonia Barasa and Alistair Miles
    Citation: Malaria Journal 2024 23:122
  33. In Madagascar, the districts of Antsirabe II, Faratsiho and Antsiranana I have relatively low malaria incidence rates and have been selected by the National Malaria Control Programme for pilot elimination stra...

    Authors: Elisabeth Gebreegziabher, Andry Raoliarison, Andrinirina Ramananjato, Andriamamonjy Fanomezana, Martin Rafaliarisoa, Sandy Ralisata, Jocelyn Razafindrakoto, Jennifer L. Smith, Jehan Ahmed and Cara Smith Gueye
    Citation: Malaria Journal 2024 23:121
  34. The increased availability and use of malaria rapid diagnostic test (RDT) by primary healthcare (PHC) workers has made universal diagnostic testing before malaria treatment more feasible. However, to meaningfu...

    Authors: Ugwu I. Omale
    Citation: Malaria Journal 2024 23:120
  35. The residual activity of a clothianidin + deltamethrin mixture and clothianidin alone in IRS covered more than the period of malaria transmission in northern Benin. The aim of this study was to show whether th...

    Authors: Esdras Mahoutin Odjo, Christian S. T. Akpodji, Armel Djènontin, Albert Sourou Salako, Gil Germain Padonou, Constantin Jésukèdè Adoha, Boulais Yovogan, Bruno Adjottin, Filémon T. Tokponnon, Razaki Osse, Clement Agbangla and Martin C. Akogbeto
    Citation: Malaria Journal 2024 23:119
  36. Authors: Giulia Manzoni, Rady Try, Jean Olivier Guintran, Céline Christiansen-Jucht, Elodie Jacoby, Siv Sovannaroth, Zaixing Zhang, Vilasack Banouvong, Matthew Scott Shortus, Rita Reyburn, Chitsavang Chanthavisouk, Nay Yi Yi Linn, Badri Thapa, San Kyawt Khine, Prayuth Sudathip, Deyer Gopinath…
    Citation: Malaria Journal 2024 23:118

    The original article was published in Malaria Journal 2024 23:64

  37. There are giant steps taken in the introduction of the novel malaria vaccine poised towards reducing mortality and morbidity associated with malaria.

    Authors: Awoere T. Chinawa, Edmund N. Ossai, Vivian O. Onukwuli, Obinna C. Nduagubam, Ndubuisi A. Uwaezuoke, Chinyere N. Okafor and Josephat M. Chinawa
    Citation: Malaria Journal 2024 23:117
  38. The use of fluorescent proteins (FPs) in Plasmodium parasites has been key to understand the biology of this obligate intracellular protozoon. FPs like the green fluorescent protein (GFP) enabled to explore prote...

    Authors: Pia J. Thiele, Raquel Mela-Lopez, Stéphanie A. Blandin and Dennis Klug
    Citation: Malaria Journal 2024 23:114
  39. Microsporidia MB, an endosymbiont naturally found in Anopheles mosquitoes inhibits transmission of Plasmodium and is a promising candidate for a transmission-blocking strategy that may involve mosquito release. A...

    Authors: Tullu Bukhari, Joseph Gichuhi, Oscar Mbare, Victoria A. Ochwal, Ulrike Fillinger and Jeremy K. Herren
    Citation: Malaria Journal 2024 23:113
  40. In malaria endemic regions of the Peruvian Amazon, rainfall together with river level and breeding site availability drive fluctuating vector mosquito abundance and human malaria cases, leading to temporal het...

    Authors: Sara A. Bickersmith, Marlon P. Saavedra, Catharine Prussing, Rachel E. Lange, Juliana A. Morales, Freddy Alava, Joseph M. Vinetz, Dionicia Gamboa, Marta Moreno and Jan E. Conn
    Citation: Malaria Journal 2024 23:112
  41. Sporozoites (SPZ), the infective form of Plasmodium falciparum malaria, can be inoculated into the human host skin by Anopheline mosquitoes. These SPZ migrate at approximately 1 µm/s to find a blood vessel and tr...

    Authors: Roos van Schuijlenburg, Samaneh Azargoshasb, Clarize M. de Korne, Jeroen C. Sijtsma, Sascha Bezemer, Alwin J. van der Ham, Els Baalbergen, Fiona Geurten, Laura M. de Bes-Roeleveld, Severine C. Chevalley-Maurel, Matthias N. van Oosterom, Fijs W. B. van Leeuwen, Blandine Franke-Fayard and Meta Roestenberg
    Citation: Malaria Journal 2024 23:111
  42. Conventional natural killer (cNK) cells play an important role in the innate immune response by directly killing infected and malignant cells and by producing pro- and anti-inflammatory cytokines. Studies on t...

    Authors: Emilie Pollenus, Fran Prenen, Hendrik Possemiers, Sofie Knoops, Tania Mitera, Jochen Lamote, Amber De Visscher, Leen Vandermosten, Thao-Thy Pham, Patrick Matthys and Philippe E. Van den Steen
    Citation: Malaria Journal 2024 23:110
  43. Malaria remains a burden globally, with the African region accounting for 94% of the overall disease burden and deaths in 2019. It is the major cause of morbidity and mortality among children in Nigeria. Thoug...

    Authors: Isaac Isiko, Simon Nyegenye, Daniel Kiprotich Bett, Jackson Micheal Asingwire, Lenz Nwachinemere Okoro, Nana Awaya Emeribe, Catherine Chepkoskei Koech, Ovye Ahgu, Naya Gadzama Bulus, Kelly Taremwa and Aaron Mwesigwa
    Citation: Malaria Journal 2024 23:109
  44. Achieving effective control and elimination of malaria in endemic regions necessitates a comprehensive understanding of local mosquito species responsible for malaria transmission and their susceptibility to i...

    Authors: Gaurav Kumar, Sanjeev Gupta, Jaspreet Kaur, Shweta Pasi, Rajendra Baharia, Ajeet Kumar Mohanty, Pawan Goel, Amit Sharma and Manju Rahi
    Citation: Malaria Journal 2024 23:107
  45. To gain a deeper understanding of protective immunity against relapsing malaria, this study examined sporozoite-specific T cell responses induced by a chemoprophylaxis with sporozoite (CPS) immunization in a r...

    Authors: Kosol Yongvanitchit, Utaiwan Kum-Arb, Amporn Limsalakpetch, Rawiwan Im-Erbsin, Ratawan Ubalee, Michele D. Spring, Brian A. Vesely, Norman Waters and Sathit Pichyangkul
    Citation: Malaria Journal 2024 23:106
  46. Malaria remains a significant global health burden affecting millions of people, children under 5 years and pregnant women being most vulnerable. In 2019, the World Health Organization (WHO) endorsed the intro...

    Authors: Atusaye J. Simbeye, Save Kumwenda, Lauren M. Cohee, Dickens Omondi, Peninah K. Masibo, Hesborn Wao and Shehu S. Awandu
    Citation: Malaria Journal 2024 23:105

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