Articles

Evaluating effectiveness of screening house eaves as a potential intervention for reducing indoor vector densities and malaria prevalence in Nyabondo, western Kenya

Mosquito-proofing of houses using wire mesh screens is gaining greater recognition as a practical intervention for reducing exposure to malaria transmitting mosquitoes. Screening potentially protects all perso...

Authors: Peter Njoroge Ng’ang’a, Collins Okoyo, Charles Mbogo and Clifford Maina Mutero

Rapid reduction of malaria transmission following the introduction of indoor residual spraying in previously unsprayed districts: an observational analysis of Mopti Region, Mali, in 2017

The National Malaria Control Programme (NMCP) of Mali has had recent success decreasing malaria transmission using 3rd generation indoor residual spraying (IRS) products in areas with pyrethroid resistance, pr...

Authors: Joseph Wagman, Idrissa Cissé, Diakalkia Kone, Seydou Fomba, Erin Eckert, Jules Mihigo, Elie Bankineza, Mamadou Bah, Diadier Diallo, Christelle Gogue, Kenzie Tynuv, Andrew Saibu, Jason H. Richardson, Christen Fornadel, Laurence Slutsker and Molly Robertson

Demonstration of indigenous malaria elimination through Track-Test-Treat-Track (T4) strategy in a Malaria Elimination Demonstration Project in Mandla, Madhya Pradesh

Many malaria endemic countries are heading towards malaria elimination through the use of case management and vector control strategies, which employ surveillance, improving access to early diagnosis, prompt t...

Authors: Praveen K. Bharti, Harsh Rajvanshi, Sekh Nisar, Himanshu Jayswar, Kalyan B. Saha, Man Mohan Shukla, Ashok K. Mishra, Ravendra K. Sharma, Aparup Das, Harpreet Kaur, Suman L. Wattal and Altaf A. Lal

Genetic diversity and complexity of Plasmodium falciparum infections in the microenvironment among siblings of the same household in North-Central Nigeria

Plasmodium falciparum parasites are known to exhibit extensive genetic diversity in areas of high transmission intensity and infected individuals in such communities often harbour several complex mixtures of para...

Authors: Segun Isaac Oyedeji, Peter Usman Bassi, Samuel Adeola Oyedeji, Olusola Ojurongbe and Henrietta Oluwatoyin Awobode

Individual, community and region level predictors of insecticide-treated net use among women in Uganda: a multilevel analysis

Use of insecticide-treated net (ITN) has been identified by the World Health Organization as an effective approach for malaria prevention. The government of Uganda has instituted measures to enhance ITN supply...

Authors: Edward Kwabena Ameyaw, Yusuf Olushola Kareem and Sanni Yaya

An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model

Malaria remains the top infectious disease threat facing the U.S. military in many forward operating environments. Compliance with malaria chemoprophylaxis remains a critical component in preventing malaria in...

Authors: Jeffrey Livezey, Patrick Twomey, Meshell Morrison, Susan Cicatelli, Elizabeth H. Duncan, Melinda Hamer, Christine Lee, Jack Hutter, Kristin Mills, Jesse DeLuca, Lucas Poon, Daniel Selig, Chau Vuong, Jason Sousa, Thomas Oliver, Jason Bennett…

Geographic and host distribution of haemosporidian parasite lineages from birds of the family Turdidae

Haemosporidians (Apicomplexa, Protista) are obligate heteroxenous parasites of vertebrates and blood-sucking dipteran insects. Avian haemosporidians comprise more than 250 species traditionally classified into...

Authors: Josef Harl, Tanja Himmel, Gediminas Valkiūnas, Mikas Ilgūnas, Támas Bakonyi and Herbert Weissenböck

No evidence of amplified Plasmodium falciparum plasmepsin II gene copy number in an area with artemisinin-resistant malaria along the China–Myanmar border

The emergence and spread of artemisinin resistance in Plasmodium falciparum poses a threat to malaria eradication, including China’s plan to eliminate malaria by 2020. Piperaquine (PPQ) resistance has emerged in ...

Authors: Fang Huang, Biraj Shrestha, Hui Liu, Lin-Hua Tang, Shui-Sen Zhou, Xiao-Nong Zhou, Shannon Takala-Harrison, Pascal Ringwald, Myaing M. Nyunt and Christopher V. Plowe

Minimal tillage and intermittent flooding farming systems show a potential reduction in the proliferation of Anopheles mosquito larvae in a rice field in Malanville, Northern Benin

Irrigation systems have been identified as one of the factors promoting malaria disease around agricultural farms in sub-Saharan Africa. However, if improved water management strategy is adopted during rice cu...

Authors: Innocent Djègbè, Merdie Zinsou, Edia Flavien Dovonou, Geneviève Tchigossou, Murielle Soglo, Razack Adéoti, Brice Gbaguidi, Seun Atoyebi, Fabrice Chandre, Martin Akogbéto, Jo Lines and Rousseau Djouaka

Costing malaria interventions from pilots to elimination programmes

Malaria programmes in countries with low transmission levels require evidence to optimize deployment of current and new tools to reach elimination with limited resources. Recent pilots of elimination strategie...

Authors: Katya Galactionova, Mar Velarde, Kafula Silumbe, John Miller, Anthony McDonnell, Ricardo Aguas, Thomas A. Smith and Melissa A. Penny

Effectiveness of peer-learning assisted primary school students educating the rural community on insecticide-treated nets utilization in Jimma-zone Ethiopia

Making insecticide-treated nets (ITNs) utilization a social norm would support the global goal of malaria eradication and Ethiopian national aim of its elimination by 2030. Jimma zone is one of the endemic set...

Authors: Yohannes Kebede, Lakew Abebe, Guda Alemayehu, Morankar Sudhakar and Zewdie Birhanu

Implementation of a malaria sentinel surveillance system in Togo: a pilot study

In Togo, the National Malaria Control Programme, in collaboration with the Global Fund to Fight AIDS, Tuberculosis and Malaria, has implemented a pilot study for malaria sentinel surveillance since 2017, which...

Authors: Anne Thomas, Tchaa A. Bakai, Tinah Atcha-Oubou, Tchassama Tchadjobo and Nicolas Voirin

Evaluation of the colorimetric malachite green loop-mediated isothermal amplification (MG-LAMP) assay for the detection of malaria species at two different health facilities in a malaria endemic area of western Kenya

Prompt diagnosis and effective malaria treatment is a key strategy in malaria control. However, the recommended diagnostic methods, microscopy and rapid diagnostic tests (RDTs), are not supported by robust qu...

Authors: James Gachugia, Winnie Chebore, Kephas Otieno, Caroline Wangari Ngugi, Adano Godana and Simon Kariuki

Correction to: Prevalence and clinical impact of malaria infections detected with a highly sensitive HRP2 rapid diagnostic test in Beninese pregnant women

An amendment to this paper has been published and can be accessed via the original article.

Authors: Valérie Briand, Gilles Cottrell, Nicaise Tuikue Ndam, Xavier Martiáñez–Vendrell, Bertin Vianou, Atika Mama, Bienvenue Kouwaye, Sandrine Houzé, Justine Bailly, Erasme Gbaguidi, Darius Sossou, Achille Massougbodji, Manfred Accrombessi, Alfredo Mayor, Xavier C. Ding and Nadine Fievet

Plasmodium falciparum gametocyte-induced volatiles enhance attraction of Anopheles mosquitoes in the field

Plasmodium parasites manipulate the interaction between their mosquito and human hosts. Patients infected with gametocytes attract anopheline mosquitoes differentially compared to healthy individuals, an effect a...

Authors: Yared Debebe, Sharon Rose Hill, Göran Birgersson, Habte Tekie and Rickard Ignell

Comparing prioritization strategies for delivering indoor residual spray (IRS) implementation, using a network approach

Indoor residual spraying (IRS) is an effective method to control malaria-transmitting Anopheles mosquitoes and often complements insecticide-treated mosquito nets, the predominant malaria vector control intervent...

Authors: Sadie J. Ryan, Anne C. Martin, Bhavneet Walia, Anna Winters and David A. Larsen

Correction to: Use of a NAT-based assay to improve the surveillance system and prevent transfusion-transmitted malaria in blood banks

An amendment to this paper has been published and can be accessed via the original article.

Authors: Daniele Rocha, Gisely Cardoso de Melo, José Marcelo Hipólito Carneiro, Marisa Ribeiro, Sthefanie Ribeiro, Daniela Tupy de Godoy, Elaine Costa, Anne Cristine Gomes de Almeida, Elisabete Ferreira de Andrade, Cláudia Maria de Moura Abrahim, Nelson Abrahim Fraiji, Antonio Gomes Pinto Ferreira, Wuelton Marcelo Monteiro, Rodrigo Brindeiro, Amilcar Tanuri, Marcus Vinicius Guimarães de Lacerda…

Towards harmonization of microscopy methods for malaria clinical research studies

Microscopy performed on stained films of peripheral blood for detection, identification and quantification of malaria parasites is an essential reference standard for clinical trials of drugs, vaccines and dia...

Authors: Mehul Dhorda, El Hadji Ba, J. Kevin Baird, John Barnwell, David Bell, Jane Y. Carter, Arjen Dondorp, Lenny Ekawati, Michelle Gatton, Iveth González, Philippe J. Guérin, Sandra Incardona, Ken Lilley, Didier Menard, François Nosten, Peter Obare…

Genetic polymorphism and natural selection of circumsporozoite protein in Myanmar Plasmodium vivax

Circumsporozoite surface protein (CSP) of malaria parasites has been recognized as one of the leading vaccine candidates. Clinical trials of vaccines for vivax malaria incorporating Plasmodium vivax CSP (PvCSP) h...

Authors: Tuấn Cường Võ, Hương Giang Lê, Jung-Mi Kang, Mya Moe, Haung Naw, Moe Kyaw Myint, Jinyoung Lee, Woon-Mok Sohn, Tong-Soo Kim and Byoung-Kuk Na

Ultra-sensitive RDT performance and antigen dynamics in a high-transmission Plasmodium falciparum setting in Mali

The recent expansion of tools designed to accurately quantify malaria parasite-produced antigens has enabled us to evaluate the performance of rapid diagnostic tests (RDTs) as a function of the antigens they d...

Authors: Emily N. Reichert, Jen C. C. Hume, Issaka Sagara, Sara A. Healy, Mahamadoun H. Assadou, Merepen A. Guindo, Rebecca Barney, Andy Rashid, Ihn Kyung Yang, Allison Golden, Gonzalo J. Domingo, Patrick E. Duffy and Hannah C. Slater

The clinical spectrum of severe childhood malaria in Eastern Uganda

Few recent descriptions of severe childhood malaria have been published from high-transmission regions. In the current study, the clinical epidemiology of severe malaria in Mbale, Eastern Uganda, is described,...

Authors: Peter Olupot-Olupot, Charles Engoru, Julius Nteziyaremye, Martin Chebet, Tonny Ssenyondo, Rita Muhindo, Gideon Nyutu, Alexander W. Macharia, Sophie Uyoga, Carolyne M. Ndila, Charles Karamagi, Kathryn Maitland and Thomas N. Williams

Molecular epidemiological surveillance of Africa and Asia imported malaria in Wuhan, Central China: comparison of diagnostic tools during 2011–2018

Malaria remains a serious public health problem globally. As the elimination of indigenous malaria continues in China, imported malaria has gradually become a major health hazard. Well-timed and accurate diagn...

Authors: Yiting Xie, Kai Wu, Weijia Cheng, Tingting Jiang, Yi Yao, Mingxing Xu, Yan Yang, Huabing Tan and Jian Li

Genetic diversity of Plasmodium falciparum in Grande Comore Island

Despite several control interventions resulting in a considerable decrease in malaria prevalence in the Union of the Comoros, the disease remains a public health problem with high transmission in Grande Comore...

Authors: Nasserdine Papa Mze, Hervé Bogreau, Cyrille K. Diedhiou, Vendela Herdell, Silai Rahamatou, Amy K. Bei, Sarah K. Volkman, Leonardo Basco, Souleymane Mboup and Ambroise D. Ahouidi

Utility of ultra-sensitive qPCR to detect Plasmodium falciparum and Plasmodium vivax infections under different transmission intensities

The use of molecular diagnostics has revealed an unexpectedly large number of asymptomatic low-density malaria infections in many malaria endemic areas. This study compared the gains in parasite prevalence obt...

Authors: Maria Gruenberg, Clara Antunes Moniz, Natalie E. Hofmann, Cristian Koepfli, Leanne J. Robinson, Elma Nate, Wuelton Marcelo Monteiro, Gisely Cardoso de Melo, Andrea Kuehn, Andre M. Siqueira, Wang Nguitragool, Quique Bassat, Marcus Lacerda, Jetsumon Sattabongkot, Ivo Mueller and Ingrid Felger

Is Anopheles gambiae attraction to floral and human skin-based odours and their combination modulated by previous blood meal experience?

Mosquitoes use odours to find energy resources, blood hosts and oviposition sites. While these odour sources are normally spatio-temporally segregated in a mosquito’s life history, here this study explored to ...

Authors: Elison E. Kemibala, Agenor Mafra-Neto, Jesse Saroli, Rodrigo Silva, Anitha Philbert, Kija Ng’habi, Woodbridge A. Foster, Teun Dekker and Leonard E. G. Mboera

Investigation of glucose-6-phosphate dehydrogenase (G6PD) deficiency prevalence in a Plasmodium vivax-endemic area in the Republic of Korea (ROK)

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most prevalent inborn disorder. This X-chromosome-linked recessive disease affects more than 400 million people globally, and is associated with haemo...

Authors: Wonsig Lee, Sang-Eun Lee, Min Jun Lee and Kyung Tae Noh

Potential drug–drug interactions associated with adverse clinical outcomes and abnormal laboratory findings in patients with malaria

Hospitalized patients with malaria often present with comorbidities or associated complications for which a variety of drugs are prescribed. Multiple drug therapy often leads to drug–drug interactions (DDIs). ...

Authors: Sidra Noor, Mohammad Ismail and Faiza Khadim

Genetic analysis of the orthologous crt and mdr1 genes in Plasmodium malariae from Thailand and Myanmar

Plasmodium malariae is a widely spread but neglected human malaria parasite, which causes chronic infections. Studies on genetic polymorphisms of anti-malarial drug target genes in P. malariae are limited. Previo...

Authors: Yupawadee Pimpat, Naowarat Saralamba, Usa Boonyuen, Sasithon Pukrittayakamee, Francois Nosten, Frank Smithuis, Nicholas P. J. Day, Arjen M. Dondorp and Mallika Imwong

Insecticide resistance in indoor and outdoor-resting Anopheles gambiae in Northern Ghana

Selection pressure from continued exposure to insecticides drives development of insecticide resistance and changes in resting behaviour of malaria vectors. There is need to understand how resistance drives ch...

Authors: Majidah Hamid-Adiamoh, Alfred Amambua-Ngwa, Davis Nwakanma, Umberto D’Alessandro, Gordon A. Awandare and Yaw A. Afrane

Quantification of Plasmodium knowlesi versus Plasmodium falciparum in the rhesus liver: implications for malaria vaccine studies in rhesus models

Rhesus macaques are valuable pre-clinical models for malaria vaccine development. The Plasmodium knowlesi/rhesus and Plasmodium falciparum/rhesus models are two established platforms for malaria vaccine testing, ...

Authors: Melanie J. Shears, Annette M. Seilie, B. Kim Lee Sim, Stephen L. Hoffman and Sean C. Murphy

Epidemiology of clinical congenital and neonatal malaria in endemic settings: a systematic review and meta-analysis

In order to attain the objectives set out in the global technical strategy against malaria 2016–2030, it is important to have accurate epidemiological data on malaria in all age categories, including those whi...

Authors: Celestin Danwang, Jean Joel Bigna, Rolf Nyah Tuku Nzalie and Annie Robert

Highlighting the burden of malarial infection and disease in the neonatal period: making sense of different concepts

Authors: Abel Nhama, Rosauro Varo and Quique Bassat

Attrition, physical integrity and insecticidal activity of long-lasting insecticidal nets in sub-Saharan Africa and modelling of their impact on vectorial capacity

Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under normal use condit...

Authors: Olivier Briet, Hannah Koenker, Laura Norris, Ryan Wiegand, Jodi Vanden Eng, Alex Thackeray, John Williamson, John E. Gimnig, Filomeno Fortes, Martin Akogbeto, Anges W. Yadouleton, Maurice Ombok, M. Nabie Bayoh, Themba Mzilahowa, Ana Paula Abílio, Samuel Mabunda…

Particle-based, Pfs230 and Pfs25 immunization is effective, but not improved by duplexing at fixed total antigen dose

The Plasmodium falciparum sexual-stage surface proteins Pfs25 and Pfs230 are antigen candidates for a malaria transmission-blocking vaccine (TBV), and have been widely investigated as such. It is not clear whethe...

Authors: Wei-Chiao Huang, Bingbing Deng, Moustafa T. Mabrouk, Amal Seffouh, Joaquin Ortega, Carole Long, Kazutoyo Miura, Yimin Wu and Jonathan F. Lovell

Prevalence and determinants of malaria infection among children of local farmers in Central Malawi

Malaria is a leading cause of morbidity and mortality among children under 5 years in Malawi, and especially among those from rural areas of central Malawi. The goal of this study was to examine the prevalence...

Authors: Emmanuel Chilanga, Delphine Collin-Vézina, Heather MacIntosh, Claudia Mitchell and Katrina Cherney

Evaluating the predictive performance of malaria antibodies and FCGR3B gene polymorphisms on Plasmodium falciparum infection outcome: a prospective cohort study

Malaria antigen-specific antibodies and polymorphisms in host receptors involved in antibody functionality have been associated with different outcomes of Plasmodium falciparum infections. Thus, to identify key p...

Authors: Duah Dwomoh, Bright Adu, Daniel Dodoo, Michael Theisen, Samuel Iddi and Thomas A. Gerds

Comparative evaluation of two commercial real-time PCR kits (QuantiFast™ and abTES™) for the detection of Plasmodium knowlesi and other Plasmodium species in Sabah, Malaysia

The monkey parasite Plasmodium knowlesi is an emerging public health issue in Southeast Asia. In Sabah, Malaysia, P. knowlesi is now the dominant cause of human malaria. Molecular detection methods for P. knowles...

Authors: Nor Afizah Nuin, Angelica F. Tan, Yao Long Lew, Kim A. Piera, Timothy William, Giri S. Rajahram, Jenarun Jelip, Jiloris F. Dony, Rashidah Mohammad, Daniel J. Cooper, Bridget E. Barber, Nicholas M. Anstey, Tock H. Chua and Matthew J. Grigg

Active case detection of malaria in pregnancy using loop-mediated amplification (LAMP): a pilot outcomes study in South West Ethiopia

125 million women are pregnant each year in malaria endemic areas and are, therefore, at risk of Malaria in Pregnancy (MiP). MiP is the direct consequence of Plasmodium infection during pregnancy. The sequestrati...

Authors: Guluma Tadesse, Claire Kamaliddin, Cody Doolan, Ranmalee Amarasekara, Ruth Legese, Abu Naser Mohon, James Cheaveau, Delenasaw Yewhalaw and Dylan R. Pillai

Efficacy of artemether-lumefantrine for treating uncomplicated Plasmodium falciparum cases and molecular surveillance of drug resistance genes in Western Myanmar

Currently, artemisinin-based combination therapy (ACT) is the first-line anti-malarial treatment in malaria-endemic areas. However, resistance in Plasmodium falciparum to artemisinin-based combinations emerging i...

Authors: Yanrui Wu, Myat Thut Soe, Pyae Linn Aung, Luyi Zhao, Weilin Zeng, Lynette Menezes, Zhaoqing Yang, Myat Phone Kyaw and Liwang Cui

Human plasma plasminogen internalization route in Plasmodium falciparum-infected erythrocytes

The intra-erythrocytic development of the malaria parasite Plasmodium falciparum depends on the uptake of a number of essential nutrients from the host cell and blood plasma. It is widely recognized that the para...

Authors: Sarah El Chamy Maluf, Marcelo Yudi Icimoto, Pollyana Maria Saud Melo, Alexandre Budu, Rita Coimbra, Marcos Leoni Gazarini and Adriana Karaoglanovic Carmona

Vector control for malaria elimination in Botswana: progress, gaps and opportunities

Botswana has in the recent past 10 years made tremendous progress in the control of malaria and this informed re-orientation from malaria control to malaria elimination by the year 2020. This progress is attri...

Authors: Tefo Kesaobaka Kgoroebutswe, Ntebaleng Makate, Ulrike Fillinger, Mandla Mpho, Godira Segoea, Peter Onyango Sangoro, Clifford Maina Mutero, Emmanuel Chanda, Davies Ntebela, Mpho Mogopa, Tjantilili Mosweunyane and Theresia Estomih Nkya

Molecular surveillance reveals the presence of pfhrp2 and pfhrp3 gene deletions in Plasmodium falciparum parasite populations in Uganda, 2017–2019

Histidine-rich protein-2 (HRP2)-based rapid diagnostic tests (RDTs) are the only RDTs recommended for malaria diagnosis in Uganda. However, the emergence of Plasmodium falciparum histidine rich protein 2 and 3 (p...

Authors: Agaba B. Bosco, Karen Anderson, Karryn Gresty, Christiane Prosser, David Smith, Joaniter I. Nankabirwa, Sam Nsobya, Adoke Yeka, Jimmy Opigo, Samuel Gonahasa, Rhoda Namubiru, Emmanuel Arinaitwe, Paul Mbaka, John Kissa, Sungho Won, Bora Lee…

The biology of unconventional invasion of Duffy-negative reticulocytes by Plasmodium vivax and its implication in malaria epidemiology and public health

Plasmodium vivax has been largely neglected over the past century, despite a widespread recognition of its burden across region where it is endemic. The parasite invades reticulocytes, employing the interaction b...

Authors: Lemu Golassa, Lucas Amenga-Etego, Eugenia Lo and Alfred Amambua-Ngwa

Correlation between anti-malarial and anti-haemozoin activities of anti-malarial compounds

Despite noticeable improvement in anti-malarial treatment, rapid growth of resistant malaria strains points out the need for continuous development of novel anti-malarials to fight the disastrous infection. Ha...

Authors: Dao Ngoc Hien Tam, Gehad Mohamed Tawfik, Amr Ehab El-Qushayri, Ghaleb Muhammad Mehyar, Sedralmontaha Istanbuly, Sedighe Karimzadeh, Vo Linh Tu, Ranjit Tiwari, Truong Van Dat, Phuong Thuy Viet Nguyen, Kenji Hirayama and Nguyen Tien Huy

Risk factors for malaria infection prevalence and household vector density between mass distribution campaigns of long-lasting insecticidal nets in North-western Tanzania

Long-lasting insecticidal nets (LLINs) are the most widely deployed vector control intervention in sub-Saharan Africa to prevent malaria. Recent reports indicate selection of pyrethroid insecticide resistance ...

Authors: Jacklin F. Mosha, Eliud Lukole, J. Derek Charlwood, Alexandra Wright, Mark Rowland, Olivia Bullock, Alphaxard Manjurano, William Kisinza, Franklin W. Mosha, Immo Kleinschmidt and Natacha Protopopoff

Detection of remaining Plasmodium DNA and gametocytes during follow up after curative malaria treatment among returned travellers in Norway

PCR can be positive weeks after effective malaria treatment, potentially leading to over diagnose of recrudescence and re-infections. The DNA detected by PCR post-treatment might stem from residuals of destroy...

Authors: Christel Gill Haanshuus and Kristine Mørch

Template copy number and the sensitivity of quantitative PCR for Plasmodium falciparum in asymptomatic individuals

The identification of asymptomatic individuals with Plasmodium falciparum infection is difficult because they do not seek medical treatment and often have too few asexual parasites detectable using microscopy or ...

Authors: Trevor A. Thompson, Mahamoudou B. Touré, Daouda Sanogo, Jeffrey G. Shaffer, Seydou O. Doumbia and Donald J. Krogstad

Rural–urban disparities and factors associated with delayed care-seeking and testing for malaria before medication use by mothers of under-five children, Igabi LGA, Kaduna Nigeria

Fever in under-five children (U5) is the commonest presenting complaint in general practice and mothers’ recognition is an entry point for fever treatment, including malaria. This study describes rural–urban d...

Authors: Obafemi J. Babalola, Olufemi Ajumobi and IkeOluwapo O. Ajayi

Combining next-generation indoor residual spraying and drug-based malaria control strategies: observational evidence of a combined effect in Mali

Ségou Region in central Mali is an area of high malaria burden with seasonal transmission. The region reports high access to and use of long-lasting insecticidal nets (LLINs), though the principal vector, Anophel...

Authors: Joseph Wagman, Idrissa Cissé, Diakalkia Kone, Seydou Fomba, Erin Eckert, Jules Mihigo, Elie Bankineza, Mamadou Bah, Diadier Diallo, Christelle Gogue, Kenzie Tynuv, Andrew Saibu, Jason H. Richardson, Christen Fornadel, Laurence Slutsker and Molly Robertson

Stable high frequencies of sulfadoxine–pyrimethamine resistance associated mutations and absence of K13 mutations in Plasmodium falciparum 3 and 4 years after the introduction of artesunate plus sulfadoxine–pyrimethamine in Ujjain, Madhya Pradesh, India

Artesunate plus sulfadoxine–pyrimethamine (ASP) is first-line treatment for uncomplicated Plasmodium falciparum malaria in most of India, except for six North-eastern provinces where treatment failure rates were ...

Authors: Ashish Pathak, Andreas Mårtensson, Sudhir Gawariker, Ashish Sharma, Vishal Diwan, Manju Purohit and Johan Ursing