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  1. Research

    Efficacies of DHA–PPQ and AS/SP in patients with uncomplicated Plasmodium falciparum malaria in an area of an unstable seasonal transmission in Sudan

    Artemisinin-based combination therapy (ACT), together with other control measures, have reduced the burden of falciparum malaria in sub-Saharan countries, including Sudan. Sudan adopted ACT in 2004 with a rema...

    Abdelrahim O. Mohamed, Muzamil M. Abdel Hamid, Omer S. Mohamed, Nuha S. Elkando, Abdelmaroof Suliman, Mariam A. Adam, Fahad Awad Ali Elnour and Elfatih M. Malik

    Malaria Journal 2017 16:163

    Published on: 20 April 2017

  2. Research

    Presence of susceptible wild strains of Anopheles gambiae in a large industrial palm farm located in Aboisso, South-Eastern of Côte d’Ivoire

    The effectiveness of malaria control programmes through implementation of vector control activities is challenged by the emergence of insecticide resistance. In the South-Eastern region of Côte d’Ivoire, wher...

    Cécile M. A. Sadia-Kacou, Ludovic P. Ahoua Alou, Ako V. C. Edi, Celine M. Yobo, Maurice A. Adja, Allassane F. Ouattara, David Malone, Alphonsine A. Koffi, Yao Tano and Benjamin G. Koudou

    Malaria Journal 2017 16:157

    Published on: 20 April 2017

  3. Research

    Defining micro-epidemiology for malaria elimination: systematic review and meta-analysis

    Malaria risk can vary markedly between households in the same village, or between villages, but the determinants of this “micro-epidemiological” variation in malaria risk remain poorly understood. This study a...

    Melanie Bannister-Tyrrell, Kristien Verdonck, Susanna Hausmann-Muela, Charlotte Gryseels, Joan Muela Ribera and Koen Peeters Grietens

    Malaria Journal 2017 16:164

    Published on: 20 April 2017

  4. Methodology

    Comparison of methods for detecting asymptomatic malaria infections in the China–Myanmar border area

    Sensitive methods for detecting asymptomatic malaria infections are essential for identifying potential transmission reservoirs and obtaining an accurate assessment of malaria epidemiology in low-endemicity ar...

    Yonghong Zhao, Yan Zhao, Yanmin Lv, Fei Liu, Qinghui Wang, Peipei Li, Zhenjun Zhao, Yingjie Liu, Liwang Cui, Qi Fan and Yaming Cao

    Malaria Journal 2017 16:159

    Published on: 20 April 2017

  5. Research

    Insecticide resistance patterns in Uganda and the effect of indoor residual spraying with bendiocarb on kdr L1014S frequencies in Anopheles gambiae s.s.

    Resistance of malaria vectors to pyrethroid insecticides has been attributed to selection pressure from long-lasting insecticidal nets (LLINs), indoor residual spraying (IRS), and the use of chemicals in agric...

    Tarekegn A. Abeku, Michelle E. H. Helinski, Matthew J. Kirby, James Ssekitooleko, Chris Bass, Irene Kyomuhangi, Michael Okia, Godfrey Magumba and Sylvia R. Meek

    Malaria Journal 2017 16:156

    Published on: 20 April 2017

  6. Research

    Quality issues with malaria rapid diagnostic test accessories and buffer packaging: findings from a 5-country private sector project in Africa

    Use of antigen-detecting malaria rapid diagnostic tests (RDTs) has increased exponentially over the last decade. WHO’s Global Malaria Programme, FIND, and other collaborators have established a quality assuran...

    Steven A. Harvey, Sandra Incardona, Nina Martin, Cristina Lussiana, Elizabeth Streat, Stephanie Dolan, Nora Champouillon, Daniel J. Kyabayinze, Robert Mugerwa, Grace Nakanwagi, Nancy Njoki, Ratsimandisa Rova and Jane Cunningham

    Malaria Journal 2017 16:160

    Published on: 20 April 2017

  7. Research

    Molecular surveillance of Plasmodium falciparum drug resistance in the Republic of Congo: four and nine years after the introduction of artemisinin-based combination therapy

    Resistance to anti-malarial drugs hinders efforts on malaria elimination and eradication. Following the global spread of chloroquine-resistant parasites, the Republic of Congo adopted artemisinin-based combina...

    Felix Koukouikila-Koussounda, Sankarganesh Jeyaraj, Christian N. Nguetse, Charles Nchotebah Nkonganyi, Kossiwa Clarisse Kokou, Mandingha K. Etoka-Beka, Francine Ntoumi and Thirumalaisamy P. Velavan

    Malaria Journal 2017 16:155

    Published on: 19 April 2017

  8. Research

    Distinct parasite populations infect individuals identified through passive and active case detection in a region of declining malaria transmission in southern Zambia

    Substantial reductions in the burden of malaria have been documented in parts of sub-Saharan Africa, with elimination strategies and goals being formulated in some regions. Within this context, understanding t...

    Kelly M. Searle, Ben Katowa, Tamaki Kobayashi, Mwiche N. S. Siame, Sungano Mharakurwa, Giovanna Carpi, Douglas E. Norris, Jennifer C. Stevenson, Philip E. Thuma and William J. Moss

    Malaria Journal 2017 16:154

    Published on: 19 April 2017

  9. Research

    Assessment of copy number variation in genes related to drug resistance in Plasmodium vivax and Plasmodium falciparum isolates from the Brazilian Amazon and a systematic review of the literature

    Parasite resistance to anti-malarials represents a great obstacle for malaria elimination. The majority of studies have investigated the association between single-nucleotide polymorphisms (SNPs) and drug resi...

    Gabriel Luíz Costa, Lara Cotta Amaral, Cor Jesus Fernandes Fontes, Luzia Helena Carvalho, Cristiana Ferreira Alves de Brito and Taís Nóbrega de Sousa

    Malaria Journal 2017 16:152

    Published on: 19 April 2017

  10. Research

    High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations

    Emergence and spread of drug resistance to every anti-malarial used to date, creates an urgent need for development of sensitive, specific and field-deployable molecular tools for detection and surveillance of...

    Yaye Dié Ndiaye, Cyrille K. Diédhiou, Amy K. Bei, Baba Dieye, Aminata Mbaye, Nasserdine Papa Mze, Rachel F. Daniels, Ibrahima M. Ndiaye, Awa B. Déme, Amy Gaye, Mouhamad Sy, Tolla Ndiaye, Aida S. Badiane, Mouhamadou Ndiaye, Zul Premji, Dyann F. Wirth…

    Malaria Journal 2017 16:153

    Published on: 19 April 2017

  11. Research

    Travel and the emergence of high-level drug resistance in Plasmodium falciparum in southwest Uganda: results from a population-based study

    The I164L mutation on the dhfr gene confers high level resistance to sulfadoxine–pyrimethamine (SP) but it is rare in Africa except in a cluster of reports where prevalence >10% in highland areas of southwest Uga...

    Caroline A. Lynch, Richard Pearce, Hirva Pota, Connie Egwang, Thomas Egwang, Amit Bhasin, Jonathan Cox, Tarekegn A. Abeku and Cally Roper

    Malaria Journal 2017 16:150

    Published on: 17 April 2017

  12. Case report

    An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia

    Imported cases of multidrug resistant Plasmodium falciparum and treatment failure with artemisinin-based regimens, although rare, have been described also in Western countries and their management is often challe...

    Raffaele Dell’Acqua, Claudia Fabrizio, Francesco Di Gennaro, Sergio Lo Caputo, Annalisa Saracino, Michela Menegon, Mariangela L’Episcopia, Carlo Severini, Laura Monno, Francesco Castelli and Gioacchino Angarano

    Malaria Journal 2017 16:149

    Published on: 14 April 2017

  13. Research

    Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening

    Blocking malaria transmission is an important step in eradicating malaria. In the field, transmission requires the production of sexual stage Plasmodium parasites, called gametocytes, which are not effectively ki...

    Wei Sun, Xiuli Huang, Hao Li, Gregory Tawa, Ethan Fisher, Takeshi Q. Tanaka, Paul Shinn, Wenwei Huang, Kim C. Williamson and Wei Zheng

    Malaria Journal 2017 16:147

    Published on: 13 April 2017

  14. Research

    Spatial clustering and risk factors of malaria infections in Bata district, Equatorial Guinea

    The transmission of malaria is intense in the majority of the countries of sub-Saharan Africa, particularly in those that are located along the Equatorial strip. The present study aimed to describe the current...

    Diana Gómez-Barroso, Emely García-Carrasco, Zaida Herrador, Policarpo Ncogo, María Romay-Barja, Martín Eka Ondo Mangue, Gloria Nseng, Matilde Riloha, Maria Angeles Santana, Basilio Valladares, Pilar Aparicio and Agustín Benito

    Malaria Journal 2017 16:146

    Published on: 12 April 2017

  15. Research

    Therapeutic efficacy and artemisinin resistance in northern Myanmar: evidence from in vivo and molecular marker studies

    In Myanmar, three types of artemisinin-based combination therapy (ACT) are recommended as first-line treatment of uncomplicated falciparum malaria: artemether–lumefantrine (AL), artesunate–mefloquine (AS + MQ)...

    Moe Kyaw Myint, Charlotte Rasmussen, Aung Thi, Dorina Bustos, Pascal Ringwald and Khin Lin

    Malaria Journal 2017 16:143

    Published on: 7 April 2017

  16. Research

    Effects of community-level bed net coverage on malaria morbidity in Lilongwe, Malawi

    The protective effect of insecticide-treated bed nets against individual-level malaria transmission is well known, however community-level effects are less understood. Protective effects from community-level b...

    Veronica Escamilla, Alisa Alker, Leonard Dandalo, Jonathan J. Juliano, William C. Miller, Portia Kamthuza, Tapiwa Tembo, Gerald Tegha, Francis Martinson, Michael Emch and Irving F. Hoffman

    Malaria Journal 2017 16:142

    Published on: 7 April 2017

  17. Meeting report

    Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group

    The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia–Pacific by 2030. During the annual meeting of the Asia Pacifi...

    Kamala Thriemer, Benedikt Ley, Albino Bobogare, Lek Dysoley, Mohammad Shafiul Alam, Ayodhia P. Pasaribu, Jetsumon Sattabongkot, Elodie Jambert, Gonzalo J. Domingo, Robert Commons, Sarah Auburn, Jutta Marfurt, Angela Devine, Mohammad M. Aktaruzzaman, Nayeem Sohel, Rinzin Namgay…

    Malaria Journal 2017 16:141

    Published on: 5 April 2017

  18. Research

    Characterization of Plasmodium falciparum genes associated with drug resistance in Hodh Elgharbi, a malaria hotspot near Malian–Mauritanian border

    A malaria hotspot in the southeastern region of Mauritania, near the Malian border, may hamper malaria control strategies. The objectives were to estimate the prevalence of genetic polymorphisms associated wit...

    Mohamed Salem Ould Ahmedou Salem, Khadijetou Mint Lekweiry, Houssem Bouchiba, Aurelie Pascual, Bruno Pradines, Ali Ould Mohamed Salem Boukhary, Sébastien Briolant, Leonardo K. Basco and Hervé Bogreau

    Malaria Journal 2017 16:140

    Published on: 5 April 2017

  19. Research

    Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar

    Myanmar has the heaviest burden of malaria in the Greater Mekong Sub-region. Asymptomatic Plasmodium spp. infections are common in this region and may represent an important reservoir of transmission that must b...

    Myo Thiha Zaw, Myo Thant, Tin Maung Hlaing, Naing Zin Aung, Min Thu, Kanit Phumchuea, Kanokwan Phusri, Teerawat Saeseu, Ritthideach Yorsaeng, Wang Nguitragool, Ingrid Felger, Jaranit Kaewkungwal, Liwang Cui and Jetsumon Sattabongkot

    Malaria Journal 2017 16:138

    Published on: 4 April 2017

  20. Methodology

    A novel model fitted to multiple life stages of malaria for assessing efficacy of transmission-blocking interventions

    Transmission-blocking interventions (TBIs) aim to eliminate malaria by reducing transmission of the parasite between the host and the invertebrate vector. TBIs include transmission-blocking drugs and vaccines ...

    Ellie Sherrard-Smith, Thomas S. Churcher, Leanna M. Upton, Katarzyna A. Sala, Sara E. Zakutansky, Hannah C. Slater, Andrew M. Blagborough and Michael Betancourt

    Malaria Journal 2017 16:137

    Published on: 4 April 2017

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