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Chimeric P. falciparum parasites expressing P. vivax circumsporozoite protein fail to produce salivary gland sporozoites

The ability to infect immunized volunteers in Controlled Human Malaria Infection (CHMI) studies with the human malaria parasite P. falciparum has transformed research into malaria vaccines. However, the ability to do so for the second most important malaria parasite, P. vivax is extremely limited.  In our study we created two chimeric P. falciparum parasites where the P. falciparum csp gene was replaced with one of the two major P. vivax csp alleles.  While the combined parasites produced sporozoite-containing oocysts in mosquitoes, most oocysts degenerated before full maturation and no sporozoites were found in their salivary glands.

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Aims and Scope

Malaria Journal is aimed at the scientific community interested in malaria in its broadest sense. It is the only journal that publishes exclusively articles on malaria and, as such, it aims to bring together knowledge from the different specialties involved in this very broad discipline, from the bench to the bedside and to the field. Malaria Journal offers a fast publication schedule while maintaining rigorous peer-review; this is achieved by managing the whole of the publication process electronically, from submission to peer-review.

Editor-in-Chief - Marcel Hommel, University of Liverpool, UK

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