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Table 1 Summary of studies of quinine for the treatment of uncomplicated malaria

From: Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

Study site Year Sample size and study population Drug Regimens Duration of follow-up Treatment outcome Comment Reference
Thailand, region with multidrug resistant malaria 1984-1985 66 children 2-12 years Quinine Quinidine 28 days DOT Cure rates: Quinine - 85% Quinidine - 88% Treatment failures only RI responses [29]
Cambodia, region with multidrug resistant malaria 1983 119 adults, >15 years Mefloquine +SP (MSP) 3 days quinine+tetracycline (Q3T7) 7 days of quinine+ tetracycline (Q7T7) 28 days DOT Cure rates: MSP: 98% Q3T7: 76% Q7T7: 92% Q7T7 still gives good cure rate [30]
Brazil, setting with quinine resistance 1985 100 patients 18-55 years Mefloquine 1000 mg single dose (MQ) 3 days quinine+SP (Q3+SP) 42 days DOT Cure rates: MQ: 96% Q3 + SP: 98% Four RI responses in Q3 + SP group [31]
Thailand, region with multidrug resistant malaria 1994 102 patients 16-60 years Mefloquine+tetracycline (MQT) 7 days of Quinine+ tetracycline (Q7T7) 28 days DOT Cure rates: MQT: 94% Q7T7: 98% MQ + Tetra as effective as Q7T7 [34]
Thailand, region with multidrug resistant malaria 1995-1997 204 male patients 15-64 years 7 days quinine (Q7) Quinine + tetracycline (Q7T7) Quinine + clindamycin (Q7C7) 28 days Directly observed therapy Cure rates: Q7: 87% Q7T7: 98% Q7C7: 100% Tetracycline or clindamycin improves quinine cure rates [33]
Equatorial Guinea, setting with no quinine resistance 1999 114 children 6-59 months 7days quinine (Q7) Chloroquine (CQ) Sulfadoxine/pyrimethamine (SP) 114 day follow-up Cure rates: Q7: 94.5% CQ: 60% SP: 90% Quinine is effective against P.falciparum malaria [43]
Cameroon, High transmission setting 2005 30 children 0.5-6 years 5 days quinine (Q5) 14 day follow-up Cure rates: 100%   [41]
Burundi Perennial transmission setting 1992-1995 472 children 0-14 years Chloroquine (CQ) 5 days quinine (Q5) 7 day follow-up Failure rates Q5: 1992-1993: 4.2% 1994-1995: 7.1%   [40]
Guinea-Bissau Perennial transmission setting 1994-1995 203 children 0.7-13 years 3 days quinine (Q3) 5 days quinine (Q5) 7 days quinine (Q7) 28-35 day follow-up Day 28 recurrent parasitemia: Q3: 79% Q5: 90% Q7: 11% 3 day quinine regimens should not be used. [37]
Gabon High transmission setting 1993-1994 120 adults = 15years 3 days quinine (Q3) 3 days quinine+clindamycin (Q3C3) 3 days quinine+doxycycline (Q3D3) 28 day follow-up Day 28 cure rates: Q3: 38% Q3C3: 92% Q3D3: 91% The two short course combinations of quinine had excellent cure rates [109]
Uganda Meso-endemic transmission setting 2007-2008 175 children 6months - 5 years 7 days quinine (Q7) 3 days artemether-lumefantrine (AL) 28 day follow-up Cure rates: Q7: 64% AL: 97% Results question the advisability of quinine use for uncomplicated malaria [45]