Table 2 In vivo anti-malarial activity of plant extracts (HA-2 and VC-1) against P. berghei infected Swiss albino mice
Sl No. | Plant Extract | Dose | Mean ± SD parasitaemia (%) | Percent suppression of parasitaemia | ED50(mg/kg) | % Survival of animal on day 10 |
|---|---|---|---|---|---|---|
DMSO | 0.1 ml/10 gm B.Wt. | 5.1 ± 2.6 | - | - | 0 | |
10 mg/kg | 3.4 ± 1.1 | 35.2 | 66 | |||
1. | HA-2 | 20 mg/kg | 2.0 ± 0.8 | 63.2 | 18.29 | 83 |
30 mg/kg | 1.5 ± 0.4 | 70.2 | 100 | |||
Chloroquine | 5 mg/kg | ND | 100 | - | 100 | |
DMSO | 0.1 ml/10 gm B.Wt. | 7.3 ± 4.09 | - | - | 0 | |
10 | 5.1 ± 1.9 | 30.1 | 50 | |||
2. | VC-1 | 15 | 3.7 ± 0.81 | 49.3 | 15.8 | 66 |
20 | 2.5 ± 1.52 | 63 | 83 | |||
Chloroquine | 5 mg/kg | ND | 100 | - | 100 |