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Table 5 Characteristics of studies that evaluated effectiveness and pharmacokinetics of quinine by route of administration (IV vs IM or indirect comparison of IR vs IV and IM vs IR) (Systematic review 3)

From: Treatment of African children with severe malaria - towards evidence-informed clinical practice using GRADE

Study ID

Age range

Country

IV Quinine Dose

IM Quinine Dose

Waller 1990 (N = 21)

19 months to 8 years

Gambia

N/A

20 mg/kg loading dose, then 10 mg/kg every 12 hours

Pasvol 1991 (N = 59)

up to 12 years

Kenya

20 mg/kg loading dose, then 10 mg/kg every 12 hours

20 mg/kg loading dose, then 10 mg/kg every 12 hours

Krishna 1991 (N = 120)

1 to 10 years

Ghana

N/A

20 mg/kg loading dose, then 10 mg/kg every 12 hours

Schapira 1993 (N = 104)

6 months to 7 years

Mozambique

20 mg/kg loading dose, then 10 mg/kg every 8 hours

20 mg/kg loading dose, then 10 mg/kg every 8 hours

Winstanley 1993 (N = 22)

7 months to 6.8 years

Kenya

14 mg/kg loading dose, then 10 mg/kg every 12 hours

20 mg/kg loading dose, then 10 mg/kg every 12 hours

Winstanley 1994 (N = 9)

1 to 3 years

Kenya

15 mg/kg loading dose, then 10 mg/kg every 12 hours

N/A

van Hensbroek 1996 (N = 16)

5 to 23 months

The Gambia

20 mg/kg loading dose, then 10 mg/kg every 12 hours

20 mg/kg loading dose, then 10 mg/kg every 12 hours

Study ID

Age

Country

IR Quinine Dose

IV Quinine Dose

Achan 2007 (N = 110)

6 months to 5 years

Uganda

20 mg/kg base loading dose, then 10 mg/kg every 8 hours, until oral treatment possible

8 mg/kg base every 8 hours, until oral treatment possible

Bareness 1998 (N = 77)

2 to 15 years

Niger

11.8 mg/kg base loading dose, then 8.8 mg/kg every 8 hours for 2 days, then oral treatment with chloroquine

4.7 mg/kg base every 8 hours for 2 days, then oral treatment with chloroquine

Study ID

Age range

Country

IR Quinine Dose

IM Quinine Dose

Bareness 2001 (N = 58)

2 to 15 years

Niger

17.9 mg/kg base loading dose, then 11.75 mg/kg base every 12 hours

7.5 mg/kg base every 12 hours

  1. Quinimax formulation which consists of 96% quinine, 2.5% quinidine, 0.68% cinchonine, and 0.67% cinchonidine
  2. N = 21 patients who received a lower dose of IV administered 10 mg/kg loading dose then 5 mg/kg every 12 hours were excluded from the IV vs IM effectiveness analysis only.