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Table 5 Characteristics of studies that evaluated effectiveness and pharmacokinetics of quinine by route of administration (IV vs IM or indirect comparison of IR vs IV and IM vs IR) (Systematic review 3)

From: Treatment of African children with severe malaria - towards evidence-informed clinical practice using GRADE

Study ID Age range Country IV Quinine Dose IM Quinine Dose
Waller 1990 (N = 21) 19 months to 8 years Gambia N/A 20 mg/kg loading dose, then 10 mg/kg every 12 hours
Pasvol 1991 (N = 59) up to 12 years Kenya 20 mg/kg loading dose, then 10 mg/kg every 12 hours 20 mg/kg loading dose, then 10 mg/kg every 12 hours
Krishna 1991 (N = 120) 1 to 10 years Ghana N/A 20 mg/kg loading dose, then 10 mg/kg every 12 hours
Schapira 1993 (N = 104) 6 months to 7 years Mozambique 20 mg/kg loading dose, then 10 mg/kg every 8 hours 20 mg/kg loading dose, then 10 mg/kg every 8 hours
Winstanley 1993 (N = 22) 7 months to 6.8 years Kenya 14 mg/kg loading dose, then 10 mg/kg every 12 hours 20 mg/kg loading dose, then 10 mg/kg every 12 hours
Winstanley 1994 (N = 9) 1 to 3 years Kenya 15 mg/kg loading dose, then 10 mg/kg every 12 hours N/A
van Hensbroek 1996 (N = 16) 5 to 23 months The Gambia 20 mg/kg loading dose, then 10 mg/kg every 12 hours 20 mg/kg loading dose, then 10 mg/kg every 12 hours
Study ID Age Country IR Quinine Dose IV Quinine Dose
Achan 2007 (N = 110) 6 months to 5 years Uganda 20 mg/kg base loading dose, then 10 mg/kg every 8 hours, until oral treatment possible 8 mg/kg base every 8 hours, until oral treatment possible
Bareness 1998 (N = 77) 2 to 15 years Niger 11.8 mg/kg base loading dose, then 8.8 mg/kg every 8 hours for 2 days, then oral treatment with chloroquine 4.7 mg/kg base every 8 hours for 2 days, then oral treatment with chloroquine
Study ID Age range Country IR Quinine Dose IM Quinine Dose
Bareness 2001 (N = 58) 2 to 15 years Niger 17.9 mg/kg base loading dose, then 11.75 mg/kg base every 12 hours 7.5 mg/kg base every 12 hours
  1. Quinimax formulation which consists of 96% quinine, 2.5% quinidine, 0.68% cinchonine, and 0.67% cinchonidine
  2. N = 21 patients who received a lower dose of IV administered 10 mg/kg loading dose then 5 mg/kg every 12 hours were excluded from the IV vs IM effectiveness analysis only.