Table 5 Characteristics of studies that evaluated effectiveness and pharmacokinetics of quinine by route of administration (IV vs IM or indirect comparison of IR vs IV and IM vs IR) (Systematic review 3)
Study ID | Age range | Country | IV Quinine Dose | IM Quinine Dose |
|---|---|---|---|---|
Waller 1990 (N = 21) | 19 months to 8 years | Gambia | N/A | 20 mg/kg loading dose, then 10 mg/kg every 12 hours |
Pasvol 1991‡ (N = 59) | up to 12 years | Kenya | 20 mg/kg loading dose, then 10 mg/kg every 12 hours | 20 mg/kg loading dose, then 10 mg/kg every 12 hours |
Krishna 1991 (N = 120) | 1 to 10 years | Ghana | N/A | 20 mg/kg loading dose, then 10 mg/kg every 12 hours |
Schapira 1993 (N = 104) | 6 months to 7 years | Mozambique | 20 mg/kg loading dose, then 10 mg/kg every 8 hours | 20 mg/kg loading dose, then 10 mg/kg every 8 hours |
Winstanley 1993 (N = 22) | 7 months to 6.8 years | Kenya | 14 mg/kg loading dose, then 10 mg/kg every 12 hours | 20 mg/kg loading dose, then 10 mg/kg every 12 hours |
Winstanley 1994 (N = 9) | 1 to 3 years | Kenya | 15 mg/kg loading dose, then 10 mg/kg every 12 hours | N/A |
van Hensbroek 1996 (N = 16) | 5 to 23 months | The Gambia | 20 mg/kg loading dose, then 10 mg/kg every 12 hours | 20 mg/kg loading dose, then 10 mg/kg every 12 hours |
Study ID | Age | Country | IR Quinine Dose | IV Quinine Dose |
Achan 2007†(N = 110) | 6 months to 5 years | Uganda | 20 mg/kg base loading dose, then 10 mg/kg every 8 hours, until oral treatment possible | 8 mg/kg base every 8 hours, until oral treatment possible |
Bareness 1998†(N = 77) | 2 to 15 years | Niger | 11.8 mg/kg base loading dose, then 8.8 mg/kg every 8 hours for 2 days, then oral treatment with chloroquine | 4.7 mg/kg base every 8 hours for 2 days, then oral treatment with chloroquine |
Study ID | Age range | Country | IR Quinine Dose | IM Quinine Dose |
Bareness 2001†(N = 58) | 2 to 15 years | Niger | 17.9 mg/kg base loading dose, then 11.75 mg/kg base every 12 hours | 7.5 mg/kg base every 12 hours |