Figure 4

Tafenoquine plasma concentration time curves for 22 individual monkeys given tafenoquine at a dose of 0.6 mg/kg/day for three days under various conditions. No other data for tafenoquine plasma levels for tafenoquine were available at any other dose. The arrows indicate the times of dosing. Maximum observed tafenoquine plasma concentrations were between 20-85 ng/ml between 48 and 96 h after dosing. Data were unavailable for the two monkeys that relapsed at this dose. Data (red circles and solid line) were available for only one of two monkeys in Cohort 2 where this dose given alone for radical cure failed in both animals, and chloroquine rescue was required.