Laboratory prediction of the requirement for renal replacement in acute falciparum malaria

Malaria Journal

Table 1 Laboratory tests used to differentiate pre-renal ARF from ATN [7–11]

Test	Formula used to calculate
Renal failure index (RFI)
Fractional excretion of sodium (FeNa)
Fractional excretion of urea (FeUN)
Plasma urea to creatinine ratio (UCR)	plasma urea/plasma creatinine
Urinary to plasma creatinine ratio (UPCR)	urinary creatinine/plasma creatinine
Urinary sodium concentration (UNa)	n/a
Urinary osmolality (UOsm)	n/a

RFI: > 1, evidence for ATN, FeNa: <1% evidence for pre-renal disease, >2% evidence for ATN, FeUN: <35% evidence for pre-renal disease, >50% evidence for ATN, UCR: >20 evidence for pre-renal disease,<15 evidence for ATN (n.b. non SI units), UPCR: >40 evidence of pre-renal disease, <20 evidence for ATN, UNa: <20 mmol/L evidence for pre-renal disease, >40 mmol/L evidence for ATN, UOsm: >500 mosm/kg evidence for pre-renal disease, <450 mosm/kg evidence for ATN. n/a: not applicable.

ISSN: 1475-2875