Laboratory prediction of the requirement for renal replacement in acute falciparum malaria

Malaria Journal

Table 6 Receiver Operating Characteristic (ROC) analysis of the ability of various laboratory tests performed on admission to predict the later requirement for RRT in patients with an admission creatinine clearance of less than 60 ml/minute

Index	Median values in patients who should have received dialysis	Patients who were able to have dialysis		Patients who should have had dialysis		p*
		AUC	95% CI	AUC	95% CI
Plasma creatinine (μmol/L)	290(226 - 379)	0.69	(0.55-0.83)	0.83	(0.74 - 0.92)
Creatinine clearance (ml/min)	24.7 (20.7 - 31)	0.66	(0.51-0.81)	0.78	(0.68 - 0.88)	0.1
RFI	2.5 (1.5 - 3.6)	0.64	(0.48-0.8)	0.75	(0.64 - 0.86)	0. 21
FeNa	1.89 (1.1 - 2.66)	0.64	(0.48-0.79)	0.75	(0.64-0.86)	0.21
Blood urea nitrogen (mmol/L)	32.5 (27.8 - 36.1)	0.66	(0.51-0.81)	0.77	(0.66 - 0.87)	0.18
UOsm (mosm/L)	382 (347 - 421)	0.74	(0.6 - 0.87)	0.71	(0.59 - 0.82)	0.1
UPCR	21.3 (17.8 - 29.5)	0.64	(0.49 - 0.78)	0.75	(0.65 - 0.86)	0.23
Urinary sodium (mmol/L)	51 (39 - 56)	0.61	(0.45 - 0.76)	0.65	(0.53 - 0.77)	0.02
UCR	28.6 (23.1 - 31.9)	0.56	(0.41 - 0.72)	0.60	(0.48 -0.72)	0.0001
FUN	36 (21 - 41)	0.37	(0.21 - 0.53)	0.41	(0.28 - 0.54)	<0.0001
Plasma bicarbonate (mmol/L)	13 (11.8 - 13.6)	0.64	(0.52 - 0.77)	0.70	(0.59 - 0.82)	0.09
Plasma potassium (mmol/L)	4.7 (4.4 - 5.1)	0.44	(0.26 - 0.61)	0.65	(0.54 - 0.77)	0.02
Urine NGAL (ng/ml)	644 (445 - 780)	0.62	(0.44 - 0.79)	0.68	(0.55 - 0.80)	0.045

* comparison of AUC in patients who should have had dialysis with plasma creatinine, using chi squared.

ISSN: 1475-2875