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Table 1 Parameters used in the study, children < 5 years

From: Strict adherence to malaria rapid test results might lead to a neglect of other dangerous diseases: a cost benefit analysis from Burkina Faso

EPIDEMIOLOGICAL PARAMETERS, CHILDREN   Source1
Malaria attributable fevers (MAF)/febrile patients (dry season) 3.18% Primary
Malaria attributable fevers (MAF)/febrile patients (rainy season) 63.05% Primary
Malaria parasite density > 40,000/μL (both seasons) 37.6% Primary
Malaria parasite density ≤40,000/μL (both seasons) 62.4% Primary
Death rate treated MAF, high parasite density 0.60% Primary
Excess death rate untreated MAF, high parasite density 9.4% Assumption
Excess death rate untreated MAF low parasite density 0.25% Assumption
Excess death rate untreated MAF in RDT neg 0.1% Assumption
Death rate treated NMFI 0.84% Primary
Proportion of potentially fatal non malarial fever (PFNM) 20% Assumption
Excess death rate untreated PFNM 7% Assumption
CASE MANAGEMENT, PRESUMPTIVE BRANCH, CHILDREN   
Anti-malarial treatment among MAF 94.1% Primary
Anti-malarial treatment among MAF, high parasite density 100% Primary
Anti-malarial treatment among MAF, low parasite density 87% Assumption
Anti-malarial treatment among those treated with antibiotics 86.3% Primary
Anti-malarial treatment among those not treated with antibiotics 97.4% Primary
Antibiotic treatment among NMFI 64.5% Primary
Antibiotic treatment among PFMN 90% Assumption
Antibiotic treatment among patients presumptively treated for malaria 54.4% Primary
Antibiotic treatment among PFMN presumptively treated for malaria 76% Assumption
Antibiotic treatment among patients not presumptively treated for malaria 89.7% Primary
Antibiotic treatment among PFMN not treated for malaria 100% Assumption
CASE MANAGEMENT, RDT, CHILDREN   
Anti-malarial treatment among RDT+, high parasite density (hpd) 100% Primary
Anti-malarial treatment among RDT+, low parasite density (lpd) 98.1% Primary
Anti-malarial treatment among RDT- 10.0% Assumption2
Antibiotic treatment among RDT+ 52.9% Primary
Antibiotic treatment among PFNM RDT+ 76% Assumption
Antibiotic treatment among RDT- 86.1% Assumption2
Antibiotic treatment among PFNM RDT- 98% Assumption
RDT ACCURACY, CHILDREN   
RDT sensitivity, malaria attributable fever (MAF), lpd, dry season 95% Primary
RDT specificity, malaria attributable fever (MAF), dry season 71% Primary
RDT sensitivity, malaria attributable fever (MAF), lpd, rainy season 95.9% Primary
RDT specificity, malaria attributable fever (MAF), rainy season 36.7% Primary
RDT sensitivity, MAF, high parasite density 100% Primary
COSTS, CHILDREN   
Cost of RDT 0.71 Ref. 26
Cost of anti-malarial treatment, Coartem (average, €) 1 Ref. 26
Cost of antibiotic treatment (average, €) 0.5 Estimate
Life Value (€) corresponding to 25 US $*YLL 525 (see text)
Life Value (€) corresponding to 150 US $*YLL 3150 (see text)
  1. 1 Primary data obtained from previous RCT (Ref. 15) and from previous assessment of the RDT accuracy (Ref. 14); assumptions based on estimates from primary data, expert opinion and previous literature (see explanation in text).
  2. 2 Assuming "ideal" 90% adherence to the negative test result (see explanation in text).