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Table 5 Univariate allele-based association tests

From: Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites

SNP* Allele
1/2
Clearance Non-clearance Chi-squared p-value
Allele 1 Allele 2 Allele 1 Allele 2
rs1012356 A/T 0.53 0.47 0.49 0.51 11.38 0.007
rs2227491 C/T 0.57 0.43 0.60 0.40 7.02 0.008
rs2227485 A/G 0.44 0.56 0.47 0.53 10.9 0.0009
rs2227478 A/G 0.64 0.36 0.66 0.34 5.89 0.02
rs2706384 A/C 0.41 0.59 0.46 0.54 18.9 0.00001
rs2057291 A/G 0.19 0.81 0.19 0.81 0.17 0.68
CD36 G1439C C/G 0.01 0.99 0.01 0.99 1.49 0.22
rs1799969 A/G 0.04 0.96 0.06 0.94 15.83 7.10 -6
rs20541 C/T 0.76 0.24 0.74 0.26 6.86 0.009
rs1800750 A/G 0.05 0.95 0.05 0.95 0.70 0.40
rs3024500 A/G 0.62 0.38 0.63 0.37 2.10 0.15
rs1805015 C/T 0.37 0.63 0.36 0.64 1.39 0.24
rs17047660 A/G 0.72 0.28 0.74 0.26 8.13 0.004
rs17047661 A/G 0.42 0.58 0.45 0.55 7.20 0.007
rs1714022 C/T 0.29 0.71 0.27 0.73 2.80 0.09
rs1126535 C/T 0.22 0.78 0.28 0.72 31.13 10 -6
rs2230739 A/G 0.86 0.14 0.86 0.14 0.54 0.46
rs229587 C/T 0.39 0.61 0.42 0.58 4.37 0.04
rs2814778 A/G 0.14 0.86 0.20 0.80 55.17 10 -6
rs3092945 C/T 0.32 0.68 0.29 0.71 10.69 0.001
rs1128127 A/G 0.44 0.56 0.47 0.53 8.19 0.004
rs1803632 C/G 0.51 0.49 0.53 0.47 4.84 0.03
rs7935564 A/G 0.46 0.54 0.45 0.55 2.39 0.12
rs4833095 C/T 0.84 0.16 0.82 0.18 5.23 0.02
rs5743809 C/T 0.06 0.94 0.05 0.95 4.92 0.03
  1. For each SNP, chi-squared comparisons were made of between the allele frequencies found in patients who cleared and did not clear drug resistant parasites. Highly significant associations are highlighted in bold. *Of the 67 SNPs genotyped for association, 42 SNPs were not included in the analysis because they were either monomorphic in one or more countries (n = 19) or for deviation from HWE in one or more of the participant countries (n = 23).