Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites

Malaria Journal

Table 5 Univariate allele-based association tests

SNP*	Allele 1/2	Clearance		Non-clearance		Chi-squared	p-value
SNP*	Allele 1/2	Allele 1	Allele 2	Allele 1	Allele 2	Chi-squared	p-value
rs1012356	A/T	0.53	0.47	0.49	0.51	11.38	0.007
rs2227491	C/T	0.57	0.43	0.60	0.40	7.02	0.008
rs2227485	A/G	0.44	0.56	0.47	0.53	10.9	0.0009
rs2227478	A/G	0.64	0.36	0.66	0.34	5.89	0.02
rs2706384	A/C	0.41	0.59	0.46	0.54	18.9	0.00001
rs2057291	A/G	0.19	0.81	0.19	0.81	0.17	0.68
CD36 G1439C	C/G	0.01	0.99	0.01	0.99	1.49	0.22
rs1799969	A/G	0.04	0.96	0.06	0.94	15.83	7.10 ^-6
rs20541	C/T	0.76	0.24	0.74	0.26	6.86	0.009
rs1800750	A/G	0.05	0.95	0.05	0.95	0.70	0.40
rs3024500	A/G	0.62	0.38	0.63	0.37	2.10	0.15
rs1805015	C/T	0.37	0.63	0.36	0.64	1.39	0.24
rs17047660	A/G	0.72	0.28	0.74	0.26	8.13	0.004
rs17047661	A/G	0.42	0.58	0.45	0.55	7.20	0.007
rs1714022	C/T	0.29	0.71	0.27	0.73	2.80	0.09
rs1126535	C/T	0.22	0.78	0.28	0.72	31.13	10 ^-6
rs2230739	A/G	0.86	0.14	0.86	0.14	0.54	0.46
rs229587	C/T	0.39	0.61	0.42	0.58	4.37	0.04
rs2814778	A/G	0.14	0.86	0.20	0.80	55.17	10 ^-6
rs3092945	C/T	0.32	0.68	0.29	0.71	10.69	0.001
rs1128127	A/G	0.44	0.56	0.47	0.53	8.19	0.004
rs1803632	C/G	0.51	0.49	0.53	0.47	4.84	0.03
rs7935564	A/G	0.46	0.54	0.45	0.55	2.39	0.12
rs4833095	C/T	0.84	0.16	0.82	0.18	5.23	0.02
rs5743809	C/T	0.06	0.94	0.05	0.95	4.92	0.03

For each SNP, chi-squared comparisons were made of between the allele frequencies found in patients who cleared and did not clear drug resistant parasites. Highly significant associations are highlighted in bold. *Of the 67 SNPs genotyped for association, 42 SNPs were not included in the analysis because they were either monomorphic in one or more countries (n = 19) or for deviation from HWE in one or more of the participant countries (n = 23).

ISSN: 1475-2875