Figure 2

Assessment of frank vascular damage in the form of haemorrhages. A-B. Haemorrhages associated with small (A) and large (B) vessels visualized with haematoxylin and eosin stain. Scale bar = 50 μm. C-D. Quantitation of haemorrhages in severe malaria expressed as either the incidence of any haemorrhages in a case (% cases; C) or number of haemorrhages per mm² (error bars indicate SEM; D) in cortex (yellow), diencephalon (orange) and brainstem (brown). There was no significant difference in the prevalence or number of haemorrhages between CM and non-CM cases or between different brain regions.