Skip to main content

Table 3 Pharmacokinetic parameters of desbutyl-lumefantrine after oral and intravenous administration of lumefantrine in rats

From: Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats

Parameters

Intravenous

Per-oral

 

0.5 mg/kg

10 mg/kg

20 mg/kg

40 mg/kg

AUC 0-t (hr*ng/mL)

375.75 ± 74.26

828.18 ± 281.31

897.39 ± 151.38

1545.89 ± 488.21

C max (ng/mL)

7.91 ± 1.89

13.54 ± 4.27

19.66 ± 3.72

34.76 ± 17.85

T max (hr)

13.5 (2-25)

24(5-30)

5(5-8)

8(5-8)

Back to article page

Malaria Journal

ISSN: 1475-2875

Contact us