Compound | D10 IC50 (μM) n = 8 | K1 IC50 (μM) n = 4 | CHO IC50 (μM) n = 2 | D10 TI | K1 TI |
---|
Dehydrobrachylaenolide | 1.865 ± 0.254 | 4.095 ± 0.579 | 17.199 | 9.2 | 4.2 |
Chloroquine | 0.038 | 0.200 | 35.800 | 942 | 179 |
- D10 = P. falciparum - chloroquine-sensitive strain
- K1 = P. falciparum - chloroquine-resistant strain
- CHO = Chinese hamster ovary cells
- n = number of technical replicates averaged - each independent experiment performed in duplicate
- TI = Therapeutic index i.e. CHO IC50/anti-plasmodial IC50