Comparative population structure of Plasmodium malariae and Plasmodium falciparum under different transmission settings in Malawi

Table 5 P. malariae and P. falciparum population differentiation

Species	District	Population	1	2	3	4	5	6	7	8	9
P. malariae	Dedza	1 Chinthankwa	-
		2 Kaphala	-0.021	-
		3 Kumfunda	0.016	0.004	-
		4 Makakhula	0.023	0.014	0.015	-
		5 Thambolagwa	0.003	-0.008	0.059	-0.012	-
	Mangochi	6 Katema	-0.020	-0.025	0.007	0.014	-0.020	-
		7 Makawa	-0.037	-0.053	-0.015	0.021	-0.020	-0.072	-
		8 Matenganya	-0.001	0.001	0.021	0.009	0.036	0.011	-0.049	-
		9 Mkali A	-0.021	-0.035	-0.083	-0.001	-0.022	-0.038	-0.043	0.008	-
		10 Mpamanda	-0.010	-0.007	0.040	-0.017	0.013	0.009	-0.029	-0.074	0.004
		Between Districts	0.008
P. falciparum	Dedza	1 Chinthankwa	-
		2 Kaphala	0.013	-
		3 Kumfunda	-0.034	-0.010	-
		4 Makakhula	-0.011	-0.002	-0.017	-
		5 Thambolagwa	0.005	0.000	-0.009	0.036	-
	Mangochi	6 Katema	0.013	0.018	0.003	-0.011	0.030	-
		7 Makawa	0.028	0.001	-0.011	0.044	-0.033	0.010	-
		8 Matenganya	0.013	0.001	-0.004	-0.002	-0.014	-0.018	-0.003	-
		9 Mkali A	-0.008	-0.004	-0.025	-0.031	0.009	-0.010	0.018	0.002	-
		10 Mpamanda	0.027	0.032	-0.012	0.035	-0.001	0.003	0.008	0.010	0.027
		Between Districts	0.003

Pairwise between-village and between-district population differentiation for P. malariae and P. falciparum. Values are Weir and Cockerham's θ estimator of Wright's Fst statistic [32]. Between-district values were calculated using all 6-locus haplotype data whilst between village values were calculated for villages with greater than seven P. malariae samples (five villages each from Dedza and Mangochi district; P. malariae, Dedza n = 83 and Mangochi n = 45; P. falciparum, Dedza n = 89 and Mangochi n = 72). P values did not reach significance for any comparisons.

ISSN: 1475-2875