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Table 1 Clinical/parasitological characteristics and angiopoietins level of enrolled patients (HC = healthy controls, MM = mild malaria, CMS = cerebral malaria survivors and CMNS = cerebral malaria non survivors)

From: Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India

Variable HC MM CMS CMNS
Number 34 57 63 29
Age (IQR) 25 (14-32) 19 (12-36) 25 (12-40) 25 (13.5-37.5)
Children, n (%) 9 (26.4) 20 (35.1) 21 (33.3) 8 (27.6)
Gender (M/F) 23/11 29/28 44/19 18/11
Coma Score (IQR) 14 14 8 (6-9) 6 (4-8)
Haemoglobin (g/dl)
(IQR)
11.6
(10-12.7)
9
(7.9-11.3)
8.1 (6-10) 6.8
(5.4-9.5)
Seizure (%) 0 0 20 (31.74) 15 (51.72)
Hypoglycaemia, n (%) 0 0 4 (6.34) 1 (3.44)
Renal failure, n (%) 0 0 15 (23.80) 8 (27.58)
Jaundice, n (%) 0 0 13 (20.63) 6 (20.68)
Hepatic Encephalopathy,
n (%)
0 0 4 (6.34) 2 (6.89)
Respiratory failure, n (%) 0 0 10 (15.87) 10 (34.48)
Haemolysis, n (%) 0 0 7 (11.11) 1 (3.44)
Abnormal bleeding, n (%) 0 0 1 (1.58) 3 (10.34)
Hypotension, n (%) 0 0 11 (17.46) 7 (24.13)
Mild anaemia, n (%) 8 (23.5) 20 (35) 20 (31.74) 6 (20.68)
Moderate anaemia, n (%) 0 9 (15.7) 21 (33.33) 9 (31.03)
Severe anaemia, n (%) 0 2 (3.5) 7 (11.11) 6 (20.68)
Neurological sequelae, n (%)
*Multiorgan dysfunction
0
0
0
0
5 (7.93)
10 (15.87)
0
8 (27.58)
ANG-1
(IQR)
12413.7 (6728.4-17590.4) 4644.4 (2508-8822.5) 2849.76 (1678.78-5211.32) 2359.61
(1582.31-5062.92)
ANG-2
(IQR)
335.9 (163.9-599.2) 968.7 (480.3-1948.9) 3580.73 (1193.59-7104.86) 7779.06 (5701.50-12197.17)
ANG-2/ANG-1
(IQR)
0.02 (0.01-0.05) 0.16 (0.08-0.47) 1.42 (0.41-2.91) 2.69 (1.06-7.04)
Parasites/300 WBCs (IQR) 0 44 (21-128) 28 (7-237) 42 (8-296)
  1. Continuous variables were presented as median inter quartile range (IQR) and categorical variables were presented as numbers (%), except gender. Groups were compared using Kruskal-Wallis test (continuous variable) and Chi-square test (categorical variables)
  2. *Multiorgan dysfunction is defined by combinations of 2 or more complications (respiratory distress, renal failure, jaundice, hypotension, gastrointestinal bleeding)