Table 1 Clinical/parasitological characteristics and angiopoietins level of enrolled patients (HC = healthy controls, MM = mild malaria, CMS = cerebral malaria survivors and CMNS = cerebral malaria non survivors)
From: Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India
Variable | HC | MM | CMS | CMNS |
|---|---|---|---|---|
Number | 34 | 57 | 63 | 29 |
Age (IQR) | 25 (14-32) | 19 (12-36) | 25 (12-40) | 25 (13.5-37.5) |
Children, n (%) | 9 (26.4) | 20 (35.1) | 21 (33.3) | 8 (27.6) |
Gender (M/F) | 23/11 | 29/28 | 44/19 | 18/11 |
Coma Score (IQR) | 14 | 14 | 8 (6-9) | 6 (4-8) |
Haemoglobin (g/dl) (IQR) | 11.6 (10-12.7) | 9 (7.9-11.3) | 8.1 (6-10) | 6.8 (5.4-9.5) |
Seizure (%) | 0 | 0 | 20 (31.74) | 15 (51.72) |
Hypoglycaemia, n (%) | 0 | 0 | 4 (6.34) | 1 (3.44) |
Renal failure, n (%) | 0 | 0 | 15 (23.80) | 8 (27.58) |
Jaundice, n (%) | 0 | 0 | 13 (20.63) | 6 (20.68) |
Hepatic Encephalopathy, n (%) | 0 | 0 | 4 (6.34) | 2 (6.89) |
Respiratory failure, n (%) | 0 | 0 | 10 (15.87) | 10 (34.48) |
Haemolysis, n (%) | 0 | 0 | 7 (11.11) | 1 (3.44) |
Abnormal bleeding, n (%) | 0 | 0 | 1 (1.58) | 3 (10.34) |
Hypotension, n (%) | 0 | 0 | 11 (17.46) | 7 (24.13) |
Mild anaemia, n (%) | 8 (23.5) | 20 (35) | 20 (31.74) | 6 (20.68) |
Moderate anaemia, n (%) | 0 | 9 (15.7) | 21 (33.33) | 9 (31.03) |
Severe anaemia, n (%) | 0 | 2 (3.5) | 7 (11.11) | 6 (20.68) |
Neurological sequelae, n (%) *Multiorgan dysfunction | 0 0 | 0 0 | 5 (7.93) 10 (15.87) | 0 8 (27.58) |
ANG-1 (IQR) | 12413.7 (6728.4-17590.4) | 4644.4 (2508-8822.5) | 2849.76 (1678.78-5211.32) | 2359.61 (1582.31-5062.92) |
ANG-2 (IQR) | 335.9 (163.9-599.2) | 968.7 (480.3-1948.9) | 3580.73 (1193.59-7104.86) | 7779.06 (5701.50-12197.17) |
ANG-2/ANG-1 (IQR) | 0.02 (0.01-0.05) | 0.16 (0.08-0.47) | 1.42 (0.41-2.91) | 2.69 (1.06-7.04) |
Parasites/300 WBCs (IQR) | 0 | 44 (21-128) | 28 (7-237) | 42 (8-296) |