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Table 1 Schedule indicating the order of Pf AMA1 antigen administration to rabbits.

From: Immunization with different Pf AMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits

Immunization group

Antigens and immunization

*Number of rabbits

 

Day 0

Day 28

Day 56

 

1 (f3h)

FVO AMA1

3D7 AMA1

HB3 AMA1

6

2 (hf3)

HB3 AMA1

FVO AMA1

3D7 AMA1

6

3 (h3f)

HB3 AMA1

3D7 AMA1

FVO AMA1

4

4 (NA mix)

NA mix

NA mix

NA mix

6

5 (DiCo mix)

DiCo mix

DiCo mix

DiCo mix

6

  1. f(FVO), 3(3D7) and h(HB3) in groups 1, 2 and 3 indicate the order of antigen administration.
  2. NA mix - an equimolar mixture of AMA1 antigens from the FVO, HB3 and 3D7 strains of P. falciparum, administered at all three immunization time points.
  3. DiCo mix - an equimolar mixture of the three Diversity-covering (DiCo) proteins, administered at all three immunization time points.
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Malaria Journal

ISSN: 1475-2875

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