Gene | Size | Exons | Signal/TM | Homology (Py vs. Pf) | Expression (Stage) |
|---|
PY03011 | 220 a.a. | 1 | Yes/Yes | 30% | S/(L) |
PY03424 | 357 a.a | 2 | Yes/No | 33% | S/L/B |
PY03661 | 225 a.a. | 1 | No/No | 60% | S/(L) |
- The genetic structure, homology and stage-specific expression of the re-annotated PY03011 gene, the re-annotated PY03424 gene and the PlasmoDB-annotated PY03661 gene are listed. Homology (Py vs. Pf) represents the amino acid homology between the P. yoelii and P. falciparum orthologs. Expression (stage) represents the stage-specific expression of the P. yoelii proteins. Previous studies indicated that PY03011/PyUIS3 and the P. falciparum PY03661 ortholog, PFC0555c, are expressed in the liver [13, 19]. Although we did not detect expression of PY03011 and PY03661 in the liver, it is likely that both proteins are expressed in the liver at levels that are below the level of detection with the serological reagents used in this study. To indicate this possibility, liver stage expression of PY03011 and PY03661 is presented in parentheses. Abbreviations: a.a. = amino acids, signal = signal sequence, TM = transmembrane region, Py = P. yoelii, Pf = P. falciparum, S = sporozoite, L = liver stage, B = blood stage.
