Table 2 Regimens for protection studies
From: Identification of two new protective pre-erythrocytic malaria vaccine antigen candidates
Protection study 1: | |||
|---|---|---|---|
Prime ← (6 wk) → | Boost ← (2 wk) → | Challenge ← (1 wk) → | Monitor parasitaemia |
Day 0 | Day 40 | Day 54 | Days 61-68 |
DNA vectors (100 ug/vector) | Vaccinia vectors (5 × 107 pfu/vector) | 300 Py spz | Blood smears |
Protection study 2: | |||
Prime ← (6 wk) → | Boost ← (2 wk) → | Challenge ← (1 wk) → | Monitor parasitaemia |
Day 0 | Day 42 | Day 57 | Days 64-71 |
DNA vectors (100 ug/vector) | Vaccinia vectors (3.3 × 107 pfu/vector) | 300 Py spz | Blood smears |
DNA-mGM-CSF (30 ug/vector) |