Table 7 RITAM Scores compared to results of good quality clinical trials in uncomplicated falciparum malaria
From: Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti-malarial plants?
Remedy | RITAM score | Clinical results | Study characteristics | Ref | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Overall | Ethnobotanical | Efficacy | Safety | Parasite clearance d7 (%) | Fever clearance d7 (%) | Side effects (%) | ACR d14 (%) | N of patients | Mean age (yrs) | Geometric mean parasitaemia d0 | ||
Artemisia annua L. (Asteraceae) aerial parts infusion | 19.9 | 0.9 | 13 | 6 | 74% | 86% | 72 | [27] | ||||
Vernonia amygdalina Delile (Asteraceae) leaf decoction | 17.0 | 5.0 | 6 | 6 | 32% | 67% | 65% | 67% | 33 | 29 | 5393 | [28] |
Argemone mexicana L. (Papaveraceae) leaf decoction | 14.9 | 1.9 | 7 | 6 | 21% | 74% | 17% | 73% | 231 | 10 | 1746 | |
Cochlospermum planchonii Hook. f. ex Planch. (Bixaceae) root decoction | 6.0 | 2.0 | 1 | 3 | 52% | 62% | 46% | 46 | 23 | 11191 | [29] | |
Combretum micranthum G. Don (Combretaceae) mixtures | 0.5 | 0.5 | 0 | 0 | 14% | 79% | 13% | 28% | 78 | 4 | 3874 | [32] |