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Table 7 RITAM Scores compared to results of good quality clinical trials in uncomplicated falciparum malaria

From: Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti-malarial plants?

Remedy RITAM score Clinical results Study characteristics Ref
Overall Ethnobotanical Efficacy Safety Parasite clearance d7 (%) Fever clearance d7 (%) Side effects (%) ACR d14 (%) N of patients Mean age (yrs) Geometric mean parasitaemia d0
Artemisia annua L. (Asteraceae) aerial parts infusion 19.9 0.9 13 6 74% 86%    72    [27]
Vernonia amygdalina Delile (Asteraceae) leaf decoction 17.0 5.0 6 6 32% 67% 65% 67% 33 29 5393 [28]
Argemone mexicana L. (Papaveraceae) leaf decoction 14.9 1.9 7 6 21% 74% 17% 73% 231 10 1746 [35, 51]*
Cochlospermum planchonii Hook. f. ex Planch. (Bixaceae) root decoction 6.0 2.0 1 3 52% 62% 46%   46 23 11191 [29]
Combretum micranthum G. Don (Combretaceae) mixtures 0.5 0.5 0 0 14% 79% 13% 28% 78 4 3874 [32]
  1. * Data from these two studies were pooled for the analysis