Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria

Table 3 Uni- and multivariate determinants of haemolytic anaemia in 12–59 months children (n = 351) treated for a clinical malaria, using conditional logistic regression

Variable	OR (95%CI)	p-value	AOR (95%CI)	p-value
Baseline Hb in g/dl	7.27 (3.63–14.54)	<0.001	7.05 (3.6–13.88)	<0.001
Log parasite density/μl	1.29 (1.06–1.59)	0.012	1.17 (0.93–1.47)	0.17
A- G6PD deficiency (vs. G6PD normal)	1.32 (0.54–3.23)	0.54	0.81^§ (0.21–3.08)	0.76
CDA (vs. other ACT^†)	1.25 (0.79–1.99)	0.34	1.28^§ (0.74–2.22)	0.37
A- G6PD and CDA (vs. G6PD normal and other ACT)*			11.13 (0.63–197)	0.25

OR = Odds Ratio. AOR = Adjusted Odds Ratio. CI = Confidence Interval.
^† artemether-lumefantrine, dihydroartemisinin-piperaquine, or amodiaquine-artesunate.
^§ AOR value when the other co-variable in the interaction term (CDA or G6PD) equals 0.
* AOR, 95% CI and p-value were computed using the Wald χ² statistic.

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