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Figure 5 | Malaria Journal

Figure 5

From: Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial

Figure 5

Proposed model of increased ACT efficacy during pregnancy. AL is active on early ring stages with a greater parasite reduction ratio, limiting parasite sequestration. Quinine is only active on mature parasites, which are sequestered in the placenta. Parasite sequestration leads to mononuclear cell infiltration and risk of poor pregnancy outcome. Haemozoin-laden macrophages become enmeshed in fibrin resulting in haemozoin deposition that persists until delivery. If women receive no or ineffective treatment, sequestered parasites, inflammation and haemozoin deposits persist until delivery.

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Malaria Journal

ISSN: 1475-2875

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