Table 5 Incidence of malaria episodes (fever and parasitemia >2500 parasites/μl) by haemoglobin genotype and age at enrollment
Age | Haemoglobin genotype | Number of children | Number of episodes | Incidence rate (95% CI) (per person-year) | District-adjusted rate ratio (95% CI) | P value |
|---|---|---|---|---|---|---|
0-1 yrs | AA | 52 | 115 | 2.7 (2.2, 3.2) | --- | --- |
AC | 15 | 31 | 2.5 (1.7, 3.5) | 0.93 (0.62, 1.38) | 0.72 | |
AS | 2 | 2 | 1.1 (0.1, 3.9) | 0.41 (0.10, 1.65) | 0.21 | |
1-2 yrs | AA | 66 | 131 | 2.3 (2.0, 2.8) | --- | --- |
AC | 16 | 22 | 1.5 (1.0, 2.3) | 0.66 (0.42, 1.04) | 0.07 | |
AS | 9 | 19 | 2.5 (1.5, 3.9) | 0.93 (0.56, 1.54) | 0.77 | |
2-3 yrs | AA | 70 | 145 | 2.5 (2.1, 2.9) | --- | --- |
AC | 10 | 8 | 0.9 (0.4, 1.7) | 0.37 (0.18, 0.75) | 0.01 | |
AS | 14 | 20 | 1.6 (1.0, 2.5) | 0.63 (0.40, 1.01) | 0.06 | |
3-4 yrs | AA | 77 | 95 | 1.4 (1.1, 1.7) | --- | --- |
AC | 17 | 32 | 2.2 (1.5, 3.1) | 1.61 (1.08, 2.41) | 0.02 | |
AS | 6 | 9 | 1.7 (0.8, 3.2) | 1.05 (0.53, 2.09) | 0.89 | |
4-5 yrs | AA | 66 | 56 | 0.9 (0.7, 1.2) | --- | --- |
AC | 10 | 11 | 1.2 (0.6, 2.2) | 1.27 (0.66, 2.44) | 0.48 | |
AS | 6 | 0 | 0.0 (0.0, 0.6) | 0.00 | 1.00 |