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Table 2 Key components of a spatial repellent critical path of development (SRCPD)

From: Spatial repellents: from discovery and development to evidence-based validation

Key components of a SRCPD
1 Proof-of-Principle: demonstrating a spatial repellent will impact disease at the community level
2 Correlating entomological endpoints with reduction in infection incidence rates using repellent tools
3 Measuring the impact of diversion of repelled vectors to untreated sources under varying transmission dynamics
4 Defining the limitations of spatial repellency in both susceptible and insecticide resistant vector populations
5 Developing standardized protocols and measures for the evaluation of vector behavior modification as it relates to host-feeding following exposure to spatial repellents (i.e., host-seeking, feeding, resting, and oviposition) to identify long-term effects of spatial repellents
6 Engagement and recruitment of industry and academic partners to adopt standardized protocols and measures for the screening of chemical AIs to include spatial repellency
7 Identifying the underlying genetic/neurobiological basis of vector behaviors to provide insight into the rationale design of new repellents