Table 2 Key components of a spatial repellent critical path of development (SRCPD)

1 Proof-of-Principle: demonstrating a spatial repellent will impact disease at the community level

2 Correlating entomological endpoints with reduction in infection incidence rates using repellent tools

3 Measuring the impact of diversion of repelled vectors to untreated sources under varying transmission dynamics

4 Defining the limitations of spatial repellency in both susceptible and insecticide resistant vector populations

5 Developing standardized protocols and measures for the evaluation of vector behavior modification as it relates to host-feeding following exposure to spatial repellents (i.e., host-seeking, feeding, resting, and oviposition) to identify long-term effects of spatial repellents

6 Engagement and recruitment of industry and academic partners to adopt standardized protocols and measures for the screening of chemical AIs to include spatial repellency

7 Identifying the underlying genetic/neurobiological basis of vector behaviors to provide insight into the rationale design of new repellents