Figure 2
From: Quantitative detection of Pf HRP2 in saliva of malaria patients in the Philippines
Configuration of the sandwich ELISA for malaria antigens. The IgM capture antibody is immobilized on the microtitre plate and binds Pf HRP2. The biotinylated IgG detector antibody binds a different epitope of Pf HRP2. The use of the biotin-streptavidin system to immobilize peroxidase enzyme provides a degree of amplification. Schematic diagram represents the possibility of multivalent recognition of epitopes by the antibodies.