Table 1 Admission demographic, clinical and laboratory details for patients included in the analysis of the efficacy of artemether-lumefantrine (Coartem™) for the treatment of uncomplicated falciparum malaria in Laos

Sex, M, no (%)

276 (50)

174 (49)

102 (53)

Age, years, median (range)

10 (0.5 - 73)

6 (0.5 - 15)

25 (16 – 73)

Body weight, kg

29.5 (28.0 – 30.9)

18.8 (17.8 – 19.8)

49.3 (48.2 – 50.4)

Height, cm

124.5 (122.0 –126.9)

108.4 (106.0 – 110.7)

154.4 (153.3 – 155.5)

Previous malaria attack, no. (%) of patients^a

151 (27.5)

89 (25)

62 (32)

Axillary temperature, °C

38.4 (38.3 - 38.5)

38.5 (38.4 - 38.7)*

38.2 (38.0 - 38.3)

Patients without fever on admission, no. (%)

147 (27)

87 (24)

60 (31)

Systolic blood pressure, mm Hg

101.9 (100.8 -103.1)

95.1 (94.2 - 96.1)*

114.6 (113.0 - 116.1)

Diastolic blood pressure, mm Hg

69.7 (68.8 – 70.6)

64.6 (63.7 - 65.5)*

79.3 (78.2 - 80.4)

Pulse, beats/min

95.1 (94.0 - 96.2)

100.4 (99.0 -101.8)*

85.3 (84.4 – 86.3)

Respiratory rate/min

27.5 (27.0 – 28.1)

29.7 (29.0 – 30.3)*

23.5 (22.9 – 24.0)

Splenomegaly, no. (%) of patients

140/547 (26)

123/355 (35)*

17/192 (9)

Hepatomegaly, no (%) of patients

116/547 (21)

112/355 (31.5)*

4/192 (2)

Lymphadenopathy, no (%) of patients

2/545 (0.4%)

2/356 (0.6%)

0

Parasitaemia, geometric mean parasites/μL (95%CI)

19,775 (17,244 – 22,678)

27,241* (23,281 – 31,875)

10,902 (8,567 – 13,872)

Mixed malaria species infection, no.(%)

11 (2)

8 (2)

3 (1.5)

Gametocytaemia, no. (%) of patients

23 (4)

19 (5)

4 (2)

Gametocytaemia, geometric mean parasite/μL (95%CI)

216 (110 – 423)

201 (97 – 415)

328 (13 – 8,195)

Haematocrit, %

35.8 (35.2 – 36.3)

33.7 (33.1 – 34.4)*

39.5 (38.7 – 40.4)

Glucose, mmol/L

6.09 (5.97 – 6.20)

6.09 (5.93 – 6.24)

6.08 (5.90 – 6.27)

Lactate, mmol/L

2.9 (2.8 – 3.0)

3.1 (2.9 – 3.2)*

2.8 (2.6 – 2.9)