Table 2 Genotype frequencies comparing uninfected controls and children with malaria for the selected SNPs

TLR4 Asp 299Gly rs4986790

Asp/Asp

300 (89.0)

528 (87.7)

300 (89.0)

528 (87.7)

Controls = 0.94

1 (reference)

Asp/Gly

36 (10.7)

72 (11.9)

36 (10.7)

71 (11.8)

Malaria = 0.78

1.14 (0.73-1.79)

0.55

Gly/Gly

1 (0.3)

2 (0.3)

1 (0.3)

3 (0.5)

1.14 (0.06-67.3)

0.92

TLR9 G1174A rs352139

GG

92 (27.3)

166 (27.5)

89 (26.4)

167 (27.8)

Controls = 0.56

1 (reference)

GA

163 (48.4)

302 (50.2)

169 (50.2)

300 (49.8)

Malaria = 0.88

1.03 (0.74-1.43)

0.87

AA

82 (24.3)

134 (22.3)

79 (23.4)

135 (22.4)

0.91 (0.61-1.34)

0.60

TLR9 T1486C rs187084

TT

197 (58.4)

342 (56.8)

191 (56.7)

340 (56.5)

Controls = 0.07

1 (reference)

TC

113 (33.6)

220 (36.6)

125 (37.1)

223 (37.0)

Malaria = 0.57

1.12 (0.83-1.51)

0.43

CC

27 (8.0)

40 (6.6)

21 (6.2)

39 (6.5)

0.85 (0.49-1.49)

0.55

TLR9 T1237C rs5743836

TT

155 (46.0)

245 (40.6)

155 (46.0)

238 (39.5)

Controls = 0.99

1 (reference)

TC

147 (43.6)

267 (44.4)

147 (43.6)

280 (46.5)

Malaria = 0.22

1.15 (0.86-1.54)

0.34

CC

35 (10.4)

90 (15.0)

35 (10.4)

84 (14.0)

1.63 (1.03-2.60)

0.03

TIRAP S180L rs8177374*

Ser/Ser

324 (96.1)

567 (94.2)

321 (95.3)

567 (94.2)

Controls = <0.001

1 (reference)

Ser/Leu

10 (3.0)

35 (5.8)

16 (4.7)

34 (5.6)

Malaria = 0.46

2.00 (0.98-4.09)

0.06

Leu/Leu

3 (0.9)

0

0 (0.0)

1 (0.2)

-

-

FCGR2a H131R rs1801274

His/His

76 (22.6)

108 (17.9)

73 (21.7)

110 (18.3)

Controls = 0.10

1 (reference)

His/Arg

152 (45.1)

299 (49.7)

159 (47.2)

295 (49.0)

Malaria = 0.72

1.38 (0.96-2.00)

0.07

Arg/Arg

109 (32.3)

195 (32.4)

105 (31.1)

197 (32.7)

1.26 (0.85-1.86)

0.23