Clindamycin plus quinine for treating uncomplicated falciparum malaria: a systematic review and meta-analysis

Malaria Journal

Table 1 Characteristics of the included trials

Reference	Location/dates	Participants	Interventions	Outcomes
40	Brazil (1987)	Adults (> 14 yrs)	Quinine +clindamycin [1] Amodiaquine (AQ) Quinine + SP	Day 28 parasite failure, PCT, adverse events
34	Gabon (1992)	Children (4-15 yrs)	Quinine+clindamycin [2] Quinine Chloroquine (CQ) CQ + clindamycin	Day 28 parasite failure, Day 14 parasite failure, PCT, adverse events
35	Gabon (1993-1994)	Adults (> 15 yrs)	Quinine + clindamycin [2] Quinine Quinine + doxycycline (Dx)	Day 28 parasite failure, Day 14 parasitological failure, PCT, adverse events
37	Thailand (1995-1997)	Adult males	Quinine +clindamycin [3] Quinine Quinine + tetracycline (Tx)	Day 28 parasite failure, PCT, FCT, adverse events
39	France (1996-1998)	Returning travelers	Quinine +clindamycin [4] Quinine	Day 28 parasite failure, PCT, FCT, adverse events
38	Thailand (1997-2000)	Pregnant women	Quinine + Clindamycin [5] Artesunate (AS)	Day 42 parasite failure, mean Hb, gametocyte carriage, adverse events
36	Gabon (2003-2004)	Children (3-12 yrs)	Quinine+clindamycin [6] Artesunate (AS2)+ clindamycin	Day 28 parasite failure, PCT, FCT, mean Hb, adverse events

Dosages: AQ: 25 mg/kg over 3 doses; CQ: 25 mg/kg over 3 days; SP: 500 mg/25 mg as single dose; AS: 12 mg/kg over 5 days; AS2: 2 mg/kg every 12 h for 6 doses; Dx: 2 mg/kg every 12 h for 6 doses; Tx: 4 mg/kg every 6 h for 7 days
[1] Quinine: 10 mg/kg every 12 h for 6 doses; clindamycin: 10 mg/kg every 12 h for 6 doses
[2] Quinine: 12 mg/kg every 12 h for 6 doses; clindamycin: 5 mg/kg every 12 h for 6 doses
[3] Quinine: 10 mg/kg every 8 h for 7 d; clindamycin 5 mg/kg every 6 h for 7 days
[4] Quinine: 8 mg/kg every 8 h for 3 days: clindamycin 5 mg/kg every 8 h for 3 days
[5] Quinine: 15 mg/kg every 12 h for 6 doses; clindamycin 7 mg/kg every 12 h for 6 doses

ISSN: 1475-2875