|
Active Pharmaceutical Ingredientq
|
Failures
|
|---|
|
Amodiaquine
|
1/49 (2.0%)
|
|
Artemether1
|
2/10 (20.0%)
|
|
Artemether and Lumefantrine1
|
10/209 (4.8%)
|
|
Artesunate1
|
10/89 (11.2%)
|
|
Chloroquine
|
66/447 (14.8%)
|
|
Dihydroartemisinin3
|
0/1 (0%)
|
|
Dihydroartemisinin-Piperaquine- Trimethoprim2
|
0/11 (0%)
|
|
Doxycycline1, 2
|
2/60 (3.3%)
|
|
Mefloquine
|
16/99 (16.2%)
|
|
Primaquine
|
55/455 (12.1%)
|
|
Quinine
|
22/130 (16.9%)
|
|
Sulfadoxine-Pyrimethamine
|
14/67 (20.9%)
|
|
Tetracycline
|
0/6 (0%)
|
- 1 Artemisinin derivatives containing medicines and doxycycline samples failed only V&P Inspection.
- 2 For medicines containing doxycycline, in Brazil, and dihydroartemisinin or piperaquine, in Suriname, there was no validated TLC method available at the time; therefore, only disintegration was assessed. Subsets of doxycycline samples sent to the reference laboratory in Brazil passed validated tests for identification and content.
