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Table 3 Test Results by API in Medicine

From: Implementation of basic quality control tests for malaria medicines in Amazon Basin countries: results for the 2005–2010 period

Active Pharmaceutical Ingredientq Failures
Amodiaquine 1/49 (2.0%)
Artemether1 2/10 (20.0%)
Artemether and Lumefantrine1 10/209 (4.8%)
Artesunate1 10/89 (11.2%)
Chloroquine 66/447 (14.8%)
Dihydroartemisinin3 0/1 (0%)
Dihydroartemisinin-Piperaquine- Trimethoprim2 0/11 (0%)
Doxycycline1, 2 2/60 (3.3%)
Mefloquine 16/99 (16.2%)
Primaquine 55/455 (12.1%)
Quinine 22/130 (16.9%)
Sulfadoxine-Pyrimethamine 14/67 (20.9%)
Tetracycline 0/6 (0%)
  1. 1 Artemisinin derivatives containing medicines and doxycycline samples failed only V&P Inspection.
  2. 2 For medicines containing doxycycline, in Brazil, and dihydroartemisinin or piperaquine, in Suriname, there was no validated TLC method available at the time; therefore, only disintegration was assessed. Subsets of doxycycline samples sent to the reference laboratory in Brazil passed validated tests for identification and content.