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Figure 8 | Malaria Journal

Figure 8

From: Immunogenicity when utilizing adenovirus serotype 4 and 5 vaccines expressing circumsporozoite protein in naïve and Adenovirus (Ad5) immune mice

Figure 8

Memory responses triggered by vaccination with homologous and heterologous prime boost regimens utilizing Ad4-CSP and Ad5-CSP in Ad5 immune animals. Splenocytes (B-C) and PBMCs (D-E) were collected two weeks after final vaccination. Cells were stained for CD62L-V450, CD127-PerCP Cy5.5, and CSP (NYD) tet-PE. CSP specific central memory T cells were determined as CD62L+ CD127+ cells that are tet+ and effector memory cells are CD62Llo CD127+ cells that are tet+. Provided above is an example of gating (A). Bars represent ± standard error. Statistical analysis was completed using One Way ANOVA with Student-Newman-Keuls post-hoc test, *, **, *** denotes significance over naïve, P < 0.05, P < 0.01, P < 0.001.

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