Table 2 Analysis of the cure rates at day 63 by site and overall (ITT and PP populations)
PCR-corrected | Uncorrected | |||
|---|---|---|---|---|
DP | A+M | DP | A+M | |
N (%) | N (%) | N (%) | N (%) | |
95% CI | 95% CI | 95% CI | 95% CI | |
ITT Population | ||||
Heterogeneity test | p=0.398a | p=0.800a | ||
Guwahati | 44 (95.7) | 22 (100) | 44 (95.7) | 22 (100) |
(DP=46, A+M=22) | 89.76; 100 | n.a. | 89.76; 100 | n.a. |
Goa | 19 (100) | 8 (88.9) | 19 (100) | 7 (77.8) |
(DP=19, A+M=9) | n.a. | 68.4; 100 | n.a. | 50.6; 100 |
Mangalore | 18 (50.0) | 11 (61.1) | 12 (33.3) | 5 (27.8) |
(DP=36, A+M=18) | 33.7; 66.3 | 38.6; 83.6 | 17.9; 48.7 | 7.1; 48.5 |
Total | 81 (80.2) | 41 (83.7) | 75 (74.3) | 34 (69.4) |
(DP=101, A+M=49) | 72.4; 88.0 | 73.3; 94.0 | 65.7; 82.8 | 56.5; 82.3 |
95% CI for DP - A+M | −16.4; 9.5 | −10.6; 20.3 | ||
PP population | ||||
Heterogeneity test | p=0.978b | p=0.574a | ||
Guwahati | 42 (100) | 22 (100) | 42 (100) | 22 (100) |
(DP=42, A+M=22) | n.a. | n.a. | n.a. | n.a. |
Goa | 19 (100) | 8 (100) | 19 (100) | 7 (87.5) |
(DP=19, A+M=8) | n.a. | n.a. | n.a. | 64.6; 100 |
Mangalore | 18 (94.7) | 11 (100) | 12 (63.2) | 5 (45.5) |
(DP=19, A+M=11) | 84.7; 100 | n.a. | 41.5; 84.9 | 16.0; 74.9 |
Total | 79 (98.8) | 41 (100) | 73 (91.3) | 34 (82.9) |
(DP=80, A+M=41) | 96.3; 100 | n.a. | 85.1; 97.4 | 71.4; 94.4 |
95% CI for DP - A+M | −3.7; 1.2 | −4.8; 21.4 | ||