Skip to main content

Advertisement

Table 2 Analysis of the cure rates at day 63 by site and overall (ITT and PP populations)

From: Therapeutic efficacy and safety of dihydroartemisinin-piperaquine versus artesunate-mefloquine in uncomplicated Plasmodium falciparum malaria in India

  PCR-corrected Uncorrected
DP A+M DP A+M
N (%) N (%) N (%) N (%)
95% CI 95% CI 95% CI 95% CI
ITT Population
Heterogeneity test p=0.398a p=0.800a
Guwahati 44 (95.7) 22 (100) 44 (95.7) 22 (100)
(DP=46, A+M=22) 89.76; 100 n.a. 89.76; 100 n.a.
Goa 19 (100) 8 (88.9) 19 (100) 7 (77.8)
(DP=19, A+M=9) n.a. 68.4; 100 n.a. 50.6; 100
Mangalore 18 (50.0) 11 (61.1) 12 (33.3) 5 (27.8)
(DP=36, A+M=18) 33.7; 66.3 38.6; 83.6 17.9; 48.7 7.1; 48.5
Total 81 (80.2) 41 (83.7) 75 (74.3) 34 (69.4)
(DP=101, A+M=49) 72.4; 88.0 73.3; 94.0 65.7; 82.8 56.5; 82.3
95% CI for DP - A+M −16.4; 9.5 −10.6; 20.3
PP population
Heterogeneity test p=0.978b p=0.574a
Guwahati 42 (100) 22 (100) 42 (100) 22 (100)
(DP=42, A+M=22) n.a. n.a. n.a. n.a.
Goa 19 (100) 8 (100) 19 (100) 7 (87.5)
(DP=19, A+M=8) n.a. n.a. n.a. 64.6; 100
Mangalore 18 (94.7) 11 (100) 12 (63.2) 5 (45.5)
(DP=19, A+M=11) 84.7; 100 n.a. 41.5; 84.9 16.0; 74.9
Total 79 (98.8) 41 (100) 73 (91.3) 34 (82.9)
(DP=80, A+M=41) 96.3; 100 n.a. 85.1; 97.4 71.4; 94.4
95% CI for DP - A+M −3.7; 1.2 −4.8; 21.4
  1. DP, dihydroartemisinin-piperaquine; A+M, artesunate-mefloquine; n.a., not assessable.
  2. aBreslow-Day; bLogistic Regression.