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Table 3 Fever prevalence and parasitaemia (ITT population)

From: Therapeutic efficacy and safety of dihydroartemisinin-piperaquine versus artesunate-mefloquine in uncomplicated Plasmodium falciparum malaria in India

  DHA-PQP n/N (%) AS + MQ n/N (%) P-value2
Fever prevalence 1
Day 0 99/101 (98.0) 49/49 (100.0) 1.000
Day 1 45/101 (44.6) 21/49 (42.9) 0.844
Day 2 30/100 (30.0) 14/49 (28.6) 0.857
Day 3 23/100 (23.0) 10/49 (20.4) 0.720
Day 7 13/98 (13.3) 7/46 (15.2) 0.752
Overall (day 0 - day 7) 99/101 (98.0) 49/49 (100.0) 1.000
Person-fever-days3 260/695 (374.1) 125/334 (374.3) 0.994
Parasitaemia
Day 0 101/101 (100) 49/49 (100)  
Day 1 37/101 (36.6) 15/49 (30.6)  
Day 2 7/101 (6.9) 4/49 (8.2)  
Day 3 0 0  
  1. DP = dihydroartemisinin-piperaquine; A + M = artesunate-mefloquine.
  2. 1Calculated, at a given time (i.e. Day 0, Day 1 etc.), as number of patients with fever (≥37.5°C) divided by the number of patients having reached that time;
  3. 2Pearson Chi-square or Fisher’s exact test, as appropriate;
  4. 3Calculated as number of days in which temperature was greater or equal to 37.5 during the first study week divided by the total number of follow up days in the first week and expressed per 1,000 person-days.