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Table 3 Fever prevalence and parasitaemia (ITT population)

From: Therapeutic efficacy and safety of dihydroartemisinin-piperaquine versus artesunate-mefloquine in uncomplicated Plasmodium falciparum malaria in India

 

DHA-PQP n/N (%)

AS + MQ n/N (%)

P-value2

Fever prevalence 1

Day 0

99/101 (98.0)

49/49 (100.0)

1.000

Day 1

45/101 (44.6)

21/49 (42.9)

0.844

Day 2

30/100 (30.0)

14/49 (28.6)

0.857

Day 3

23/100 (23.0)

10/49 (20.4)

0.720

Day 7

13/98 (13.3)

7/46 (15.2)

0.752

Overall (day 0 - day 7)

99/101 (98.0)

49/49 (100.0)

1.000

Person-fever-days3

260/695 (374.1)

125/334 (374.3)

0.994

Parasitaemia

Day 0

101/101 (100)

49/49 (100)

 

Day 1

37/101 (36.6)

15/49 (30.6)

 

Day 2

7/101 (6.9)

4/49 (8.2)

 

Day 3

0

0

 
  1. DP = dihydroartemisinin-piperaquine; A + M = artesunate-mefloquine.
  2. 1Calculated, at a given time (i.e. Day 0, Day 1 etc.), as number of patients with fever (≥37.5°C) divided by the number of patients having reached that time;
  3. 2Pearson Chi-square or Fisher’s exact test, as appropriate;
  4. 3Calculated as number of days in which temperature was greater or equal to 37.5 during the first study week divided by the total number of follow up days in the first week and expressed per 1,000 person-days.