Skip to main content

Table 1 Clinical and biological parameters of Patients characteristics

From: Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia

 

SMA

CM

UM

P value

P value

SMA vs. CM (1)

SMA vs. CM vs. UM (2)

No. children

108

144

80

  

Age (years)

3.5 (1–5)

3.1 (1–6)

3.8 (2–6)

NSb

NSb

Sex [n (%)]

     

  Male

59 (54.6)

78 (54.2)

44 (55)

NSa

NSa

  Female

49 (45.4)

66 (45.8)

36 (45)

NSa

NSa

Hb (g/dL)

4.3 (3.7-4.7)

6.3 (5–8.02)

9.6 (8.4-10.9)

= .0001

≤ .0001

RBC (109/μL)

1.77 (1.5-2)

2.73 (2.2-3.3)

3.9 (3.6-4.2)

= .0001

≤ .078

WBC (106/μL)

12.1 (8.5-19.1)

11.4 (8.3-15.5)

12.4 (8–15.6)

NSb

NSb

Lymphocyte(106/μL)

5.3 (2.9-8.1)

3 (1.8-4.8)

1.9 (1.5-3.3)

NSb

≤ .0051

Monocytes (106/μL)

0.6 (0.3-1.2)

0.5 (0.2-0.9)

0.7 (0.5-0.9)

NSb

NSb

Parasitaemia

41322(5060–989003)

52356(5676–1872368)

61000(7396–434024)

NSb

NSb

HCM (%)

3.3 (0–10)

10 (0–20)

0 (0–3.3)

= .032

≤ .039

  1. Values given are medians numbers (25th-75th percentiles) except when indicated otherwise and for parasitaemia [geometric mean (range)]. CM, SMA, UM and AC refer to cerebral malaria, severe malarial anaemia, uncomplicated malaria and asymptomatic controls, respectively. HCM = haemozoin-containing monocytes.
  2. (1) Comparison between SMA and CM.
  3. (2) Comparison between the three groups SMA, CM and UM.
  4. a Statistical significance was obtained using the chi-square test.
  5. b Statistical significance was obtained using the using Mann-Whitney’s test (1) or Kruskal-Wallis’ test (2).