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Table 2 Spontaneous and stimulated IL-10 and TNF production in malaria patients

From: Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia

  Spontaneous LPS-stimulated PHA-stimulated
IL-10 SMA 24.3 (11–39.6) 188.8 (70–342) 55.3 (30.8-176.6)
  CM 201.5 (39–744.8) 623.4 (521.1-1028.25) 608.9 (148.05-725.25)
  UM 100 (22.4-323.2) 198.2 (140.6-349.8) 310 (125.3-494.4)
  AC 12.6 (5.7-17.4) 25.8 (5.1-406) 588.4 (434.2-811)
TNF SMA 71.1 (24.2-181) 2196 (1595.5-3025.5) 2219 (929.5-3606)
  CM 192.4 (91.5-366.1) 425.6 (217.3-513.7) 876.2 (366.4-1514.5)
  UM 72.6 (42.9-105.2) 1344 (388.2-2461) 1352 (703.7-2534.5)
  AC 55.5 (16.3-94.7) 1265 (544.8-4435) 5857 (2437–9203)
  1. IL-10 and TNF levels were measured by ELISA in the supernatant of un-stimulated whole-blood (spontaneous production) or after LPS or PHA stimulation as described in Methods. Data are presented as median and interquartile range in pg/mL. CM, SMA, UM and AC refer to cerebral malaria, severe malarial anaemia, uncomplicated malaria and asymptomatic controls, respectively.