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Table 1  In vitro  anti-malarial activities of drugs against chloroquine-susceptible (9A) and -resistant (K1) strains of  Plasmodium falciparum 

From: A simple and inexpensive haemozoin-based colorimetric method to evaluate anti-malarial drug activity

Drugs

Mean IC50and 95% CI (μM)

 

 P. falciparum  K1 strain

 P. falciparum  9A strain

Quinine

0.258 (0.242 - 0.275)

0.398 (0.307 - 0.516)

Chloroquine

0.873 (0.824 - 0.926)

0.132 (0.082 - 0.211)

Clotrimazole

0.805 (0.689 - 0.939)

1.67 (1.18 – 2.37)

Pyrimethamine

23.03 (18.36 - 28.90)

Not done

Artemisinin

0.139 (0.124 - 0.155)

0.483 (0.376 - 0.622)

  1. Parasitized red blood cells were incubated with different concentrations of drugs for 72 hr and parasite growth was evaluated using the haemozoin-based colorimetric method. The IC50 and its 95% confidence interval (95% CI) were calculated from the concentration-response curve of the haemozoin level vs the log concentration of a drug
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Malaria Journal

ISSN: 1475-2875

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