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Table 2 Panel of multidrug resistant strains including specifc amino acid changes

From: A framework for assessing the risk of resistance for anti-malarials in development

  drug resistancea pfcrt b pfmdr1 c pfdhfr d pfdhps e pfcytb  
Strain CHQ SUL PYR CYC MEF ATO 72 73 74 75 76 86 184 1034 1042 1246 copy 16 51 59 108 164 436 437 581 613 268 Origin MR4 number Ref.
NF54 S S S S S S C V M N K N Y S N D 1 A N C S I S G A A Y Imported MRA-100 [25]
D6 S S S S R S C V M N K N Y S N D 1 A N C S I A A A A   Cloned from Sierra Leone I/CDC MRA-285 [26]
HB3 S S R S S S C V M N K N Y S D D 1 A N C N I S A A A   Cloned from Honduras I/CDC MRA-155 [27]
7 G8 R S R R    S V M N T N F C D Y 1 A I C N I S G A A   Cloned from IMTM 22 (Brazil) MRA-152 [28]
Dd2 R R R R R   C V I E T Y Y S N D 4 A I R N I F G A S   Cloned from W2-Mef (Indochina III/CDC) MRA-150 [29]
V1/S R R R R    C V I E T Y Y S N D   A I R N L F G A T   Cloned from V1 (Vietnam) MRA-176 [30]
K1 R R R R    C V I E T Y Y S N D 1 A N R N I S G G A   Thailand MRA-159 [31]
FCB R   S R    C V I E T Y Y S N D 2 V N C T I       Columbia MRA-309 [32]
TM90C2B R   R   R R C V I E T N F S N D            S Thailand N/A [3]
  1. aS: sensitive, R: resistant, as reported in the literature.
  2. bAllelic information based on references[3335].
  3. cAllelic information based on references[33, 3537].
  4. dAllelic information based on references[18, 35, 38].
  5. eAllelic information based on references[20, 3941].