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Table 5 Sensitivity analysis of outcome misclassification *

From: Delayed Plasmodium falciparum clearance following artesunate-mefloquine combination therapy in Thailand, 1997–2007

  Uncorrected Alker 2007 Hutagalung 2005 Rogers 2009
Sensitivity 25.9 22.6 15.1 15.4
Specificity 88.5 95.0 94.6 95.1
PPV 13.5 27.8 24.2 34.3
NPV 94.6 93.4 90.6 87.0
  1. Abbreviations: PPV positive predictive value, NPV negative predictive value.
  2. *The uncorrected estimates are from this study. The relationship between day-28 PCR-uncorrected treatment failure and 42-day PCR-corrected treatment failure from three different studies was used to calculate the sensitivity, specificity, PPV, and NPV of day-2 parasitaemia as an indicator of 42-day PCR-corrected treatment failure.