Figure 8

A-B Proportion of 100 hypothetical patients cured. Panel A: EC50 values of mefloquine (287, 554 and 821 ng/ml) for two different dosing schemes: 8.3 mg/kg at 0, 24 and 48 hours (WHO standard; circles); and 15 mg/kg at 48 hours (alternative scheme; crosses). Panel B: EC50 values of piperaquine (32, 53 and 74 ng/ml) for two different dosing schemes: 18 mg/kg at 0, 24 and 48 hours (WHO standard; circles); and 36 mg/kg at 0, 24 and 48 hours (alternative scheme; crosses).