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Figure 8 | Malaria Journal

Figure 8

From: Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

Figure 8

A-B Proportion of 100 hypothetical patients cured. Panel A: EC50 values of mefloquine (287, 554 and 821 ng/ml) for two different dosing schemes: 8.3 mg/kg at 0, 24 and 48 hours (WHO standard; circles); and 15 mg/kg at 48 hours (alternative scheme; crosses). Panel B: EC50 values of piperaquine (32, 53 and 74 ng/ml) for two different dosing schemes: 18 mg/kg at 0, 24 and 48 hours (WHO standard; circles); and 36 mg/kg at 0, 24 and 48 hours (alternative scheme; crosses).

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