ARS – artesunate, ART – artemether, DHA – dihydroartemisinin, LF – lumefantrine, MQ – mefloquine, PQ – piperaquine.
†Parameter values were taken from the literature: dihydroartemisinin, artemether, lumefantrine, mefloquine, piperaquine. Between-subject variability (BSV%) presented as standard deviation multiplied by 100 (lognormal error model).
aka – absorption rate constant; CL/F – clearance; V/F – volume of distribution; Vc – volume of central compartment; Q – inter-compartmental clearance; and Vp –volume of peripheral compartment.
bDihydroartemisinin profiles were simulated for artesunate, since dihydroartemisinin is the primary active metabolite of artesunate and artesunate is considered the pro-drug.