Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

Table 2 Population pharmacokinetic parameter values (BSV%) ^† for each drug

ARS – artesunate, ART – artemether, DHA – dihydroartemisinin, LF – lumefantrine, MQ – mefloquine, PQ – piperaquine.
^†Parameter values were taken from the literature: dihydroartemisinin[16], artemether[17], lumefantrine[17], mefloquine[18], piperaquine[19]. Between-subject variability (BSV%) presented as standard deviation multiplied by 100 (lognormal error model).
^ak_a – absorption rate constant; CL/F – clearance; V/F – volume of distribution; Vc – volume of central compartment; Q – inter-compartmental clearance; and Vp –volume of peripheral compartment.
^bDihydroartemisinin profiles were simulated for artesunate, since dihydroartemisinin is the primary active metabolite of artesunate and artesunate is considered the pro-drug.
^cPK parameters are for a 48kg individual.
^d/day.
^eL/kg/day.
^fL/kg.

ISSN: 1475-2875