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Table 3 Parameter definitions for the within-host pharmacokinetic-pharmacodynamic model

From: Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

Parameter Description
μ IPL Mean of the age distribution of the initial parasite burden
σ IPL Standard deviation of the age distribution of the initial parasite burden
PMF Parasite multiplication factor (/48 h cycle)
k max Maximal killing rate of the drug / h
γ Slope of in vivo concentration-effect curve
EC 50 In vivo concentration when killing rate is 50% of the maximum