Skip to main content

Table 3 Parameter definitions for the within-host pharmacokinetic-pharmacodynamic model

From: Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

Parameter

Description

μ IPL

Mean of the age distribution of the initial parasite burden

σ IPL

Standard deviation of the age distribution of the initial parasite burden

PMF

Parasite multiplication factor (/48 h cycle)

k max

Maximal killing rate of the drug / h

γ

Slope of in vivo concentration-effect curve

EC 50

In vivo concentration when killing rate is 50% of the maximum

Back to article page

Malaria Journal

ISSN: 1475-2875

Contact us