Malaria resistance genes are associated with the levels of IgG subclasses directed against Plasmodium falciparum blood-stage antigens in Burkina Faso

Table 2 Family-based association analyses for anti- Plasmodium falciparum IgG levels

Locus	SNP ID number	Allele^a (AF^b)	P^c
IL12Bpro (promoter)	rs17860508	TTAGAG/GC (0.3068)	P > 0.05
IL12B (3'UTR)	rs3212227	A/C (0.3275)	P > 0.05
IL4-590 (promoter)	rs2243250	C/T (0.8017)	P > 0.05
FCGR2A H/R131 (exon 4)	rs1801274	C/T (0.5371)	T^d (0.0166^f)
HbC (exon1)	rs33930165	A/C (0.1682)	C ^d (0.0091 ^e,g )
HbS (exon1)	rs334	A/T (0.0193)	P > 0.05
LTA + 80 (intron 1)	rs2239704	C/A (0.3542)	P > 0.05
TNF- 1031(promoter)	rs1799964	T/C (0.1106)	P > 0.05
TNF-863 (promoter)	rs1800630	C/A (0.0858)	A^d (0.0440^e)
TNF-857 (promoter)	rs1799724	C/T (0.0228)	T ^d (0.0064 ^e,g )
TNF-308 (promoter)	rs1800629	G/A (0.1063)	P > 0.05
TNF-238 (promoter)	rs361525	G/A (0.0264)	P > 0.05
TNF 1304 (intron 3)	rs3093664	A/G (0.075)	A ^d (0.0083 ^e,g )
NCR3-412 (promoter)	rs27362191	G/C (0.2267)	P > 0.05
NCR3*3790 (3'UTR)	rs986475	T/C (0.0272)	C^d (0.0307^e)

Abbreviations: HbC, Haemoglobin C; IL4, Interleukin 4; LTA, Lymphotoxin-α; AF, allele frequency; NCR3, Natural cytotoxicity receptor 3; SNP, Single-nucleotide polymorphism; TNF, Tumour necrosis factor; UTR, Untranslated region.
^aWild allele / variant allele.
^bVariant allele frequency that was calculated in the study population.
^cChi-square test P-value for IgG levels.
^dAllele positively associated.
^eAdditive model.
^fDominant model.
^gSignificant P value after applying a false discovery rate of 10%.

ISSN: 1475-2875