Impact of pre-existing MSP142-allele specific immunity on potency of an erythrocytic Plasmodium falciparum vaccine

Table 2 Reactivity of MSP1 specific T cells from ICR mice demonstrates strong strain-specific IFN-γ responses

^a Strength of response: + ≥ 15 SFC, ++ ≥30, +++ ≥ 45 SFC. Responses of mice immunized only with saline/Montanide ISA-720 did not exceed 3 ± 2 SFC/10⁶ splenocytes when stimulated with any of the antigens used. Splenocytes stimulated with GST as control antigen did not exceed 2 ± 2 SFC/10⁶ splenocytes.
^b MSP1₄₂ allele used for ex vivo stimulation. Bold characters highlight the magnitude of the homologous response.

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