Table 5 Paediatric Patients

Artemether/Lumefantrine (Riamet™, Riamet Dispersible™) (20/120 mg)

5–14 kg: 1 tablet per dose

Registered for treatment of patients of ≥5 kg body weight

15–24 kg: 2 tablets per dose

Dispersible drug formulation is registered in Switzerland

25–34 kg: 3 tablets per dose

> 35 kg: 4 tablets per dose

for 6 doses (0–8–24–36–48–60 h)⁴

Dihydroartemisinin/Piperaquine (Eurartesim™)°

5 - < 7 kg: ½ tablet 160 mg/20 mg

Registered for treatment of patients of ≥5 kg body weight

7 - < 13 kg 1 tablet 160 mg/20 mg

No paediatric drug formulation, but two strengths of tablets make use of this ACT feasible in children

13 - < 24 kg: 1 tablet 320 mg/40 mg

24 - < 36 kg: 2 tablets 320 mg/20 mg

36 - < 75 kg: 3 tablets 320 mg/40 mg

75-100 kg: 4 tablets 320 mg/40 mg once daily for three days

Atovaquone/Proguanil (Malarone™, Malarone Paediatric™)

5–8 kg: 2 tablets Malarone Paediatric

Registered for treatment of patients with >5 kg body weight

9–10 kg: 3 tablets Malarone Paediatric

11–20 kg: 1 tablet Malarone

21–30 kg: 2 tablets Malarone

31–40 kg: 3 tablets Malarone

>40 kg KG: 4 tablets Malaroneonce daily for three days

Quinine*/Doxycycline

Contraindicated in children below 8 years of age (13 years in some countries)

No drug registration

Loose drug combination

Quinine*/Clindamycin

Thrice daily 10 mg/kg quinine plus twice daily 10 mg/kg clindamycin for 7 days

No drug registration

Loose drug combination

Mefloquine (Lariam™)

5 - 10 kg: ½ - 1 tablet

Registered for treatment of patients of ≥5 kg body weight

10–20 kg: 1–2 tablets

20–30 kg: 2–3 tablets (2 + 1)

30–45 kg: 3–4 tablets (2 + 2)

45–60 kg: 5 tablets (3 + 2)

> 60 kg 6 tablets (3 + 2 + 1)

20-25 mg/kg total dose divided in 1–3 doses 6 hours apart