Table 3 Risk of severe disease among adult patients with Plasmodium knowlesi malaria – univariate modeling
From: Laboratory markers of disease severity in Plasmodium knowlesi infection: a case control study
Variable | Uncomplicated malaria n (%) | Severe malaria n (%) | Crude odds ratio (95% CI) | p-value† | |
|---|---|---|---|---|---|
PCN count (PCN/μl) | 0 | 41 (44.1) | 2 (11.8) | 1 | <0.0001 |
1 – 139 | 32 (34.4) | 1 (5.9) | 0.64 (0.06 – 7.38) | ||
140 – 415 | 14 (15.1) | 3 (17.6) | 4.39 (0.66 – 29.06) | ||
≥416 | 6 (6.4) | 11 (54.7) | 37.58 (6.64 – 212.67) | ||
Parasite count (parasites/μl) | <100000 | 85 (91.4) | 9 (52.9) | 1 | 0.0003 |
≥100000 | 8 (8.6) | 8 (47.1) | 9.44 (2.85 – 31.28) | ||
Parasite count (% IRBC) | <2 | 80 (86) | 7 (41.2) | 1 | 0.0001 |
≥2 | 13 (14) | 10 (58.8) | 8.79 (2.84 – 27.21) | ||
Platelet count (x 103 platelets/μl) | ≥60 | 54 (58.1) | 2 (11.8) | 1 | 0.001 |
36-59 | 18 (19.3) | 8 (47) | 12 (2.33 – 61.78) | ||
≤35 | 21 (22.6) | 7 (41.2) | 9 (1.72 – 46.87) |