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Table 2 In vivo anti-malarial activity of 2,3,6-trihydroxy benzoic acid (1)

From: Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo

Drug dose (mg/kg) Mean % Suppression/Inhibition
Suppressive test
10 22.73  
30 35.95 cSD50 = 44.9 ± 1.6 mg/kg
50 53.66
100 69.63
Quinine sulfate (24 mg/kg) 71.34
Curative test
10 20.95  
30 41.00 cED50= 42.2 ± 1.6 mg/kg
50 57.27
100 66.40
Quinine sulfate (24 mg/kg) 89.50
  1. cSuppressive/Effective dose at 50%= concentration of drug that cleared/reduced parasitaemia by 50%. Percentages of inhibition were calculated based on the parasitaemia obtained 24 h after the last drug administration.