Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo

Table 2 In vivo anti-malarial activity of 2,3,6-trihydroxy benzoic acid (1)

Drug dose (mg/kg)	Mean % Suppression/Inhibition
Suppressive test
10	22.73
30	35.95	^cSD₅₀ = 44.9 ± 1.6 mg/kg
50	53.66
100	69.63
Quinine sulfate (24 mg/kg)	71.34
Curative test
10	20.95
30	41.00	^cED₅₀= 42.2 ± 1.6 mg/kg
50	57.27
100	66.40
Quinine sulfate (24 mg/kg)	89.50

^cSuppressive/Effective dose at 50%= concentration of drug that cleared/reduced parasitaemia by 50%. Percentages of inhibition were calculated based on the parasitaemia obtained 24 h after the last drug administration.

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