Box (25th to 75th percentile) and whisker (1.5*interquartile range) plot of the full covariate model with estimated gestational age implemented as a linear continuous covariate. Panel A displays the percent change per week of gestational age where the solid black zero-line represents no covariate effect. MTT is the mean transit time, Vc/F, Vp1/F and Vp2/F is the apparent volume of the central compartment, the first peripheral compartment ant the second peripheral compartment, respectively. CL/F is the apparent elimination clearance and Q1/F and Q2/F is the apparent inter-compartmental clearances. Panel B displays the elimination clearance estimates for non-pregnant women, women in the second trimester (week 20) and women in the third trimester (week 32).