Skip to main content

Table 3 Therapeutic efficacy of AM and AL at days 28, 42 and 63 in adult patients in Senegal – IIT and PP analysis

From: Efficacy and tolerability of a new formulation of artesunate-mefloquine for the treatment of uncomplicated malaria in adult in Senegal: open randomized trial

Outcome Artesunate Mefloquine (n = 157) Artemether Lumefantrine (n = 153) p value
Intention to treat analysis    
Early treatment failure 00 00 -
NA 6 (3.82%) 4 (2.61%) 0.77
Crude Parasitological failure at day 28 1 (0.64%) 4 (2.61%) 0.35
PCR adjusted failure rate 1 (0.64%) 1 (0.65%)  
PCR adjusted cure rate at day 28 150 (95.54%) 148 (96.73%) 0.58
  Artesunate Mefloquine Artemether Lumefantrine  
Per protocol analysis    
Early treatment failure 00 00 -
Crude parasitological failure 1/151 (0.66%) 4/149 (2.6%) 0.17
PCR adjusted failure rate 1/151 (0.66%) 1/149 (0.67%) 0.99
PCR adjusted cure rate at day 28 150/151 (99.34%) 148/149 (99.33%) 0.99
Crude parasitological failure at day 42 2/70 (2.8%) 5/57 (8.7% 0.20
PCR adjusted ACPR at day 42 69/70 (98.5%) 56/57 (98.2%) 1
Crude parasitological failure at day 63 4/57 (7%) 6/44 (13%) 0.32
PCR adjusted ACPR at day 63 56/57 (98.2%) 43/44 (97.7%) 1
  1. NA = Not applicable.